1 research outputs found
Effects of Methoxy Substituents on the Glutathione Peroxidase-like Activity of Cyclic Seleninate Esters
Cyclic
seleninate esters function as mimetics of the antioxidant
enzyme glutathione peroxidase and catalyze the reduction of hydrogen
peroxide with a stoichiometric thiol. While a single electron-donating
methoxy substituent <i>para</i> to the selenium atom enhances
the catalytic activity, <i>m</i>-methoxy groups have little
effect and <i>o</i>-methoxy substituents suppress activity.
The effects of multiple methoxy groups are not cumulative. This behavior
can be rationalized by opposing mesomeric and steric effects. Oxidation
of the product disulfide via its thiolsulfinate was also observed