Porównanie maksymalnego ciśnienia zamknięcia cewki moczowej mierzone cewnikiem typu mikrotip i cewnikiem wypełnionym powietrzem – badanie randomizowane

Background: Measurements of maximum urethral closure pressure (MUCP) are a part of urodynamic investigations preceding an incontinence surgery and a part of urethral function tests. Objectives: The aim of the study was to compare maximum urethral closure pressure determined by a microtip catheter with those measured by an air-charged catheter. Material and methods: A prospective randomized study in a tertiary referral centre. 122 female patients with urodynamic stress incontinence were randomly assigned to have their urethral pressure profi les measured at rest by both microtip and air-charged catheters. Intervention and Measurements: Each patient had three measurements taken by each catheter type. Means of the measurements were compared with regard to correlation and repeatability. For statistical analysis, an approach proposed by Bland-Altman was applied to assess the agreement between the two techniques. Results: Correlation coeffi cient between MUCP by the air-charged and the microtip catheter was r=0.8507(95% CI 0.7928 – 0.8934; pCel: Pomiar maksymalnego ciśnienia zamknięcia cewki moczowej (MUCP) jest częścią badania urodynamicznego poprzedzającego operacyjne leczenie nietrzymania moczu i częścią testow czynnościowych cewki moczowej. Celem pracy było porownanie maksymalnego ciśnienia zamknięcia cewki moczowej zmierzonego przy pomocy cewnika microtip i cewnika wypełnionego powietrzem. Materiał i metoda: Przeprowadzono prospektywne, randomizowane badanie w ośrodku trzeciego stopnia referencyjności. Do badania losowo włączono 122 kobiety z nietrzymaniem moczu, u których wykonywano profi l ciśnień w cewce moczowej w spoczynku przy pomocy zarówno cewnika microtip jak i cewnika wypełnionego powietrzem. Każda pacjentka miała wykonane trzy pomiary przy pomocy obu cewników. Średnie z pomiarów porównano w odniesieniu do korelacji i powtarzalności. Do celów statystycznych użyto metody Bland-Altmana oceniającej zgodność obu technik pomiarów. Wyniki: Współczynnik korelacji pomiędzy MUCP mierzonym cewnikiem powietrznym a cewnikiem microtip wynosił r=0,8507(95% CI 0,7928–0,8934;

A Framework for the Systematic Evaluation of Data and Analytics Use Cases at an Early Stage

Due to the immense growth of collected data and advancing big data technologies, there are countless potential use cases of data and analytics. But most data initiatives fail and do not bring the desired outcome. One essential reason for this situation is the lack of a systematic approach to evaluate and select promising analytics use cases. This study presents an evaluation framework that enables the systematic screening at an early stage by assessing nine criteria with the help of a scoring model. It also supports a prioritization among several use cases and facilitates the communication to decision makers. The action design research approach was followed to build, test, and evaluate the framework in three iterative design cycles. It was developed in close collaboration with Bundesdruckerei GmbH, an IT-security company owned by the German government that offers products and services for secure identities, data, and infrastructures

How is Your Mood Today? - A Taxonomy-based Analysis of Apps for Depression

Depression is a serious disease that affects partners, families, friends, and societies. Applications for depression therapy support assist users in daily life to cope with depression challenges. While the services provided can be advantageous, the benefits and apps provided in the market can be overwhelming and fragmented for its intended users. A rigorous classification and clustering of this important domain is still missing. We deduce insights examining a taxonomy and conducting a cluster analysis. We classify 55 applications into eleven dimensions and 46 corresponding characteristics. We identify six clusters of archetypical application configurations. Our procedure classifies this application domain and enables directions towards more tailored research for this eHealth and mHealth artefacts. (Potential) users and application developers can use our results and findings to improve their usage and development and select the most suitable application for their medical needs and interests

Gene expression in cultured endometrium from women with different outcomes following IVF

Estradiol and progesterone are crucial for the acquisition of receptivity and the change in transcriptional activity of target genes in the implantation window. The aim of this study was to differentiate the regulation of genes in the endometrium of patients with recurrent implantation failure (IF) versus those who became pregnant after in vitro fertilization (IVF) treatment. Moreover, the effect of embryo-derived factors on endometrial transcriptional activity was studied. Nine women with known IVF outcome (IF, M, miscarriage, OP, ongoing pregnancy) and undergoing hysteroscopy with endometrial biopsy were enrolled. Biopsies were taken during the midluteal phase. After culture in the presence of embryo-conditioned IVF media, total RNA was extracted and submitted to reverse transcription, target cDNA synthesis, biotin labelling, fragmentation and hybridization using the Affymetrix Human Genome U133A 2.0 Chip. Differential expression of selected genes was re-analysed by quantitative PCR, in which the results were calculated as threshold cycle differences between the groups and normalized to Glyceraldehyde phosphate dehydrogenase and β-actin. Differences were seen for several genes from endometrial tissue between the IF and the pregnancy groups, and when comparing OP with M, 1875 up- and 1807 down-regulated genes were returned. Real-time PCR analysis confirmed up-regulation for somatostatin, PLAP-2, mucin 4 and CD163, and down-regulation of glycodelin, IL-24, CD69, leukaemia inhibitory factor and prolactin receptor between Op and M. When the different embryo-conditioned media were compared, no significant differential regulation could be demonstrated. Although microarray profiling may currently not be sensitive enough for studying the effects of embryo-derived factors on the endometrium, the observed differences in gene expression between M and OP suggest that it will become an interesting tool for the identification of fertility-relevant markers produced by the endometriu

Field strength correlators in full QCD

We study, by numerical simulations on a lattice, the behaviour of the gauge-invariant two-point correlation functions of the gauge field strengths in the QCD vacuum with dynamical fermions.Comment: 11 pages, LaTeX file, + 2 PS figure

Top-Down and Bottom-Up Contributions to Understanding Sentences Describing Objects in Motion

Theories of embodied language comprehension propose that the neural systems used for perception, action, and emotion are also engaged during language comprehension. Consistent with these theories, behavioral studies have shown that the comprehension of language that describes motion is affected by simultaneously perceiving a moving stimulus (Kaschak et al., 2005). In two neuroimaging studies, we investigate whether comprehension of sentences describing moving objects activates brain areas known to support the visual perception of moving objects (i.e., area MT/V5). Our data indicate that MT/V5 is indeed selectively engaged by sentences describing objects in motion toward the comprehender compared to sentences describing visual scenes without motion. Moreover, these sentences activate areas along the cortical midline of the brain, known to be engaged when participants process self-referential information. The current data thus suggest that sentences describing situations with potential relevance to one's own actions activate both higher-order visual cortex as well brain areas involved in processing information about the self. The data have consequences for embodied theories of language comprehension: first, they show that perceptual brain areas support sentential-semantic processing. Second the data indicate that sensory-motor simulation of events described through language are susceptible to top-down modulation of factors such as relevance of the described situation to the self