Filling in the Gap: A quantitative analysis of dental restoration types among body donors of Asian descent at the Mann-Labrash Osteological Collection

The Mann-Labrash Osteological Collection at the University of Hawai’i John A. Burns School of Medicine houses over 230 skeletal remains amassed through the Willed Body Program. Of these donors, seventy-eight were of East and Southeast Asian American and Pacific Islander descent. This unique collection offers an exciting opportunity for skeletal analyses of these populations left understudied in the body of anthropological scientific literature. This thesis explores the dietary causes of dental disease and dental restorations from the past to the present. Additionally, macroscopic analyses and Chi-square statistical tests determined which sex cohorts utilized dental restorative prostheses in life. Also addressed are the socioeconomic determinants of dental care access among these underrepresented groups. Lastly, because of the marginal availability of East and Southeast Asian American and Pacific Islander skeletal remains in US reference collections, an examination of death ideologies and organ donor hesitancies held by these communities are reviewed

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele