Risk analysis of MUSCULOSKELETAL DISORDERS (MSDs) on Logistic Distribution Workers in Warehouse of PT. X Surabaya

This research discussed about risk of Musculoskeletal Disorders (MSDs) on logistic distribution workers in warehouse of PT X Surabaya. MSDs are tissue damage on skeletal muscle parts (joint, ligament and tendon_) caused by body receiving static load or working on awkward posture repeatedly in long term. This research was semi quantitative descriptive analytic research with cross sectional study design. Working posture used REBA (Rapid Entire Body Assessment) method, MSD complaint used Nordic Body Map and working load used Calorimeter Heart Rate Watch. Research result showed that home theater system experienced the highest MSDs complaint. Furthermore statistical test used Spearman and Pearson correlation which found that variable related to musculoskeletal complaint is lifting load. P value (0,04

Pengaruh Kontribusi Peserta dan Hasil Investasi Terhadap Surplus Underwriting Dana Tabarru’ Pada Perusahaan Asuransi Jiwa Syariah di Indonesia Februari 2015 – Desember 2016

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh kontribusi peserta dan hasil investasi secara parsial dan simultan terhadap surplus underwriting dana tabarru’ pada perusahaan asuransi jiwa syariah di Indonesia. Penelitian yang digunakan dalam penelitian ini adalah kuantitatif, metode penelitian yang digunakan dalam skripsi ini yaitu analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa variabel kontribusi peserta memiliki pengaruh positif dan signifikan terhadap surplus underwriting dana tabarru’ asuransi jiwa syariah dengan nilai koefesien sebesar 0,032 atau 32% dan memiliki nilai signifikansi sebesar 0,000 < 0,05. Variabel hasil investasi memiliki pengaruh negatif dan signifikan terhadap surplus underwriting dana tabarru’ asuransi jiwa syariah dengan nilai koefesien sebesar -0,029 atau -29% dan memiliki nilai signifikansi sebesar 0,000 < 0,05. Variabel kontribusi peserta dan hasil investasi secara simultan berpengaruh positif dan signifikan terhadap surplus underwriting dana tabarru’. Dengan nilai uji F-hitung sebesar 83,237 sedangkan F-tabel sebesar 3,47 dengan nilai signifikansi 0,000 < 0,05

DEMAND FOR ANIMAL FOOD IN THE RURAL AND URBAN OF MALUKU, INDONESIA

Protein deficiency has a permanent and long-term effect, which is a decrease in intelligence, abnormal growth, and stunting. Maluku is the province with the lowest protein consumption in Indonesia. The purpose of this study is to analyze the impact of price, income, and demographic factors on animal protein food demand, using the Quadratic Almost Ideal Demand System approach. The research data used 2016 Susenas data of 4,811 households. The results showed that an increase in animal food prices by one percent decreased demand for eggs, chicken, beef, fresh fish and milk powder, respectively, by 0.452%, 2,024%, 4,382%, 2,507%, and 0.969%. The most elastic beef was followed by chicken, fresh fish, milk powder, and eggs with income elasticities of 3,928%, 2,278%, 1,752%, 1,456%, and 0.562%, respectively. All animal foods are luxury items, except eggs are normal goods. In urban areas, beef, fresh fish and milk power are complementary, whereas in rural areas all animal foods are substitutes. Moreover, the impacts of socio-demographic factors on the demand for animal products were found to be very low. To increase protein consumption, the Maluku government needs to maintain the stability of animal food prices, especially eggs. Price policies are more effective than income policies both in urban and rural area

Pilus PilA of the naturally competent HACEK group pathogen Aggregatibacter actinomycetemcomitans stimulates human leukocytes and interacts with both DNA and proinflammatory cytokines

Each HACEK group pathogen, which can cause infective endocarditis, expresses type IVa pili. The type IVa major pilin PilA plays a role in bacterial colonization, virulence, twitching motility, and the uptake of extracellular DNA. The type IV prepilin homolog PilA of the periodontal pathogen A. actinomycetemcomitans (AaPilA) is linked to DNA uptake and natural competence. Our aim was to investigate the virulence properties and immunogenic potential of AaPilA. Since Neisseria meningitidis PilE, which shares sequence similarity with AaPilA, participates in sequestering host cytokines, we examined the ability of AaPilA to interact with various cytokines. Moreover, we investigated the structural characteristics of AaPilA with molecular modeling. AaPilA was conserved among A. actinomycetemcomitans strains. One of the 18 different natural variants, PilAD7S, is present in naturally competent strains. This variant interacted with DNA and bound interleukin (IL)-8 and tumor necrosis factor (TNF)-α. Specific anti-AaPilA antibodies were present in A. actinomycetemcomitans-positive periodontitis patient sera, and the production of reactive oxygen species from human neutrophils was less effectively induced by the ΔpilA mutant than by the wild-type strains. However, AaPilA did not stimulate human macrophages to produce proinflammatory cytokines, nor was it cytotoxic. The results strengthen our earlier hypothesis that the DNA uptake machinery of A. actinomycetemcomitans is involved in the sequestration of inflammatory cytokines. Furthermore, AaPilA stimulates host immune cells, such as B cells and neutrophils, making it a potential virulence factor.</p

Subfoveal Choroidal and Macular Thickness Assessed with Optical Coherence Tomography in Indonesian Subjects with Type 2 Diabetes: A Cross-Sectional Study

Objective: The present study aims to assess the difference in choroidal and macular thickness in type 2 diabetes (T2D) patients with and without diabetic retinopathy (DR). Materials and methods: This cross-sectional analytic study included 84 eyes from 56 subjects by consecutive sampling which were divided into control, T2D without DR/non-diabetic retinopathy (NDR), and T2D with DR/diabetic retinopathy (DR) group. The subjects were patients with T2D aged 40–60 years with or without DR, with normal intraocular pressure, and never received any DR therapy. The data collected were age, gender, mean arterial pressure, glycemic control, choroidal thickness (CT), and macular thickness (MT). Results: Mean age of the NDR group was 51.67 ± 4.64 years, the DR group was 52.45 ± 4.46 years, and the control group was 51.31 ± 5.72 years. Subjects in DR group (247.57 ± 57.95 microns) had significantly thinner choroids when compared to the NDR group (266.68 ± 51.76 microns), they both also had significantly thinner choroids when compared to the control group (283.07 ± 69.98; p = 0.042). On the contrary, subjects in DR group (263.79 ± 45.17 microns) had thicker macula compared to the NDR (236.11 ± 26.49 microns) and control group (239.82 ± 17.42 microns; p = 0.015). Conclusions: Subjects with type 2 diabetes and retinopathy had significantly thinner choroid and thicker macula when compared to non-diabetic retinopathy group. The thinning of choroid and thickening of macula develops as the disease progresses to diabetic retinopathy

Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity of a large proportion of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade inflammation. Because of the large genetic diversity within the species, both harmless and highly virulent genotypes of the bacterium have emerged. The oral condition and age, as well as the geographic origin of the individual, influence the risk to be colonized by a virulent genotype of the bacterium. In the present review, the virulence and pathogenicity properties of A. actinomycetemcomitans will be addressed

Decreased temperature increases the expression of a disordered bacterial late embryogenesis abundant (LEA) protein that enhances natural transformation

Late embryogenesis abundant (LEA) proteins are important players in the management of responses to stressful conditions, such as drought, high salinity, and changes in temperature. Many LEA proteins do not have defined three-dimensional structures, so they are intrinsically disordered proteins (IDPs) and are often highly hydrophilic. Although LEA-like sequences have been identified in bacterial genomes, the functions of bacterial LEA proteins have been studied only recently. Sequence analysis of outer membrane interleukin receptor I (BilRI) from the oral pathogen Aggregatibacter actinomycetemcomitans indicated that it shared sequence similarity with group 3/3b/4 LEA proteins. Comprehensive nuclearcgq magnetic resonance (NMR) studies confirmed its IDP nature, and expression studies in A. actinomycetemcomitans harboring a red fluorescence reporter protein-encoding gene revealed that bilRI promoter expression was increased at decreased temperatures. The amino acid backbone of BilRI did not stimulate either the production of reactive oxygen species from human leukocytes or the production of interleukin-6 from human macrophages. Moreover, BilRI-specific IgG antibodies could not be detected in the sera of A. actinomycetemcomitans culture-positive periodontitis patients. Since the bilRI gene is located near genes involved in natural competence (i.e., genes associated with the uptake of extracellular (eDNA) and its incorporation into the genome), we also investigated the role of BilRI in these events. Compared to wild-type cells, the ΔbilRI mutants showed a lower transformation efficiency, which indicates either a direct or indirect role in natural competence. In conclusion, A. actinomycetemcomitans might express BilRI, especially outside the host, to survive under stressful conditions and improve its transmission potential.</p

Moving from information and collaboration to action: report from the 3rd International Dog Health Workshop, Paris in April 2017

Abstract Background Breed-related health problems in dogs have received increased focus over the last decade. Responsibility for causing and/or solving these problems has been variously directed towards dog breeders and kennel clubs, the veterinary profession, welfare scientists, owners, regulators, insurance companies and the media. In reality, all these stakeholders are likely to share some responsibility and optimal progress on resolving these challenges requires all key stakeholders to work together. The International Partnership for Dogs (IPFD), together with an alternating host organization, holds biennial meetings called the International Dog Health Workshops (IDHW). The Société Centrale Canine (French Kennel Club) hosted the 3rd IDHW, in Paris, in April, 2017. These meetings bring together a wide range of stakeholders in dog health, science and welfare to improve international sharing of information and resources, to provide a forum for ongoing collaboration, and to identify specific needs and actions to improve health, well-being and welfare in dogs. Results The workshop included 140 participants from 23 countries and was structured around six important issues facing those who work to improve dog health. These included individualized breed-specific strategies for health and breeding, extreme conformations, education and communication in relation to antimicrobial resistance, behavior and welfare, genetic testing and population-based evidence. A number of exciting actions were agreed during the meeting. These included setting up working groups to create tools to help breed clubs accelerate the implementation of breed-health strategies, review aspects of extreme conformation and share useful information on behavior. The meeting also heralded the development of an online resource of relevant information describing quality measures for DNA testing. A demand for more and better data and evidence was a recurring message stressed across all themes. Conclusions The meeting confirmed the benefits from inclusion of a diverse range of stakeholders who all play relevant and collaborative parts to improve future canine health. Firm actions were set for progress towards improving breed-related welfare. The next international workshop will be in the UK in 2019 and will be organized by the UK Kennel Club