Can Measuring Levels of Serum Adhesion Proteins Replace the Ankle Brachial Index in the Fight Against Peripheral Artery Disease?

If you knew that you were going to have one of both of your legs amputated due to a preventable medical condition in the future, then any sane person would want to find a way of preventing such a disabling and life changing event. Currently peripheral artery disease (PAD) is a growing threat to health in modern times, which can lead to the situation mentioned above. Due to diet and lifestyle risk factors, PAD incidence has increased as the world has become more developed.1 Mankind is unlikely to stop its march onward towards ever more developed states of living, which likely will mean even less healthy diets and more sedentary lifestyles in the years to come. With the trends as they are, with more than eight million Americans currently suffering from PAD and that number actively rising worldwide it is clear that something must be done.2 While it is not currently agreed upon that PAD screening should be conducted in asymptomatic individuals, this is primarily due to the infeasibility of accurately conducting such screens. A secondary hurdle is that screening is something that is typically only conducted when there is an established methodology for preventing the progression of, or reversing the damage done by, the condition. With things as they are, it might seem that there is no hope for PAD screening, but a new age is dawning thanks to cutting-edge research

The Recent Star Formation in NGC 6822: an Ultraviolet Study

We characterize the star formation in the low-metallicity galaxy NGC 6822 over the past few hundred million years, using GALEX far-UV (FUV, 1344-1786 A) and near-UV (NUV, 1771-2831 A) imaging, and ground-based Ha imaging. From GALEX FUV image, we define 77 star-forming (SF) regions with area >860 pc^2, and surface brightness <=26.8 mag(AB)arcsec^-2, within 0.2deg (1.7kpc) of the center of the galaxy. We estimate the extinction by interstellar dust in each SF region from resolved photometry of the hot stars it contains: E(B-V) ranges from the minimum foreground value of 0.22mag up to 0.66+-0.21mag. The integrated FUV and NUV photometry, compared with stellar population models, yields ages of the SF complexes up to a few hundred Myr, and masses from 2x10^2 Msun to 1.5x10^6 Msun. The derived ages and masses strongly depend on the assumed type of interstellar selective extinction, which we find to vary across the galaxy. The total mass of the FUV-defined SF regions translates into an average star formation rate (SFR) of 1.4x10^-2 Msun/yr over the past 100 Myr, and SFR=1.0x10^-2 Msun/yr in the most recent 10 Myr. The latter is in agreement with the value that we derive from the Ha luminosity, SFR=0.008 Msun/yr. The SFR in the most recent epoch becomes higher if we add the SFR=0.02 Msun/yr inferred from far-IR measurements, which trace star formation still embedded in dust (age <= a few Myr).Comment: Accepted for publication in ApJ, 21 pages, 6 figures, 3 table

VIS: the visible imager for Euclid

Euclid-VIS is a large format visible imager for the ESA Euclid space mission in their Cosmic Vision program, scheduled for launch in 2019. Together with the near infrared imaging within the NISP instrument it forms the basis of the weak lensing measurements of Euclid. VIS will image in a single r+i+z band from 550-900 nm over a field of view of ~0.5 deg2. By combining 4 exposures with a total of 2240 sec, VIS will reach to V=24.5 (10{\sigma}) for sources with extent ~0.3 arcsec. The image sampling is 0.1 arcsec. VIS will provide deep imaging with a tightly controlled and stable point spread function (PSF) over a wide survey area of 15000 deg2 to measure the cosmic shear from nearly 1.5 billion galaxies to high levels of accuracy, from which the cosmological parameters will be measured. In addition, VIS will also provide a legacy imaging dataset with an unprecedented combination of spatial resolution, depth and area covering most of the extra-Galactic sky. Here we will present the results of the study carried out by the Euclid Consortium during the Euclid Definition phase.Comment: 10 pages, 6 figure

African-American Folk Art in Kentucky

1998 Kentucky Folk Art Center exhibition catalog of African-American folk art from Kentucky.https://scholarworks.moreheadstate.edu/kfac_exhibition_catalogs/1017/thumbnail.jp

A Catalog of Chandra X-ray Sources in the Carina Nebula

We present a catalog of ~14,000 X-ray sources observed by the ACIS instrument on the Chandra X-ray Observatory within a 1.42 square degree survey of the Great Nebula in Carina, known as the Chandra Carina Complex Project (CCCP). This study appears in a Special Issue of the ApJS devoted to the CCCP. Here, we describe the data reduction and analysis procedures performed on the X-ray observations, including calibration and cleaning of the X-ray event data, point source detection, and source extraction. The catalog appears to be complete across most of the field to an absorption-corrected total-band luminosity of ~10^{30.7} erg/s for a typical low-mass pre-main sequence star. Counterparts to the X-ray sources are identified in a variety of visual, near-infrared, and mid-infrared surveys. The X-ray and infrared source properties presented here form the basis of many CCCP studies of the young stellar populations in Carina.Comment: Accepted for the ApJS Special Issue on the Chandra Carina Complex Project (CCCP), scheduled for publication in May 2011. All 16 CCCP Special Issue papers are available at http://cochise.astro.psu.edu/Carina_public/special_issue.html through 2011 at least. 29 pages, 11 figure

Combined analysis of weak lensing and X-ray blind surveys

We present a joint weak lensing and X-ray analysis of 4 deg$^2$ from the CFHTLS and XMM-LSS surveys. Our weak lensing analysis is the first analysis of a real survey using shapelets, a new generation weak lensing analysis method. We create projected mass maps of the images, and extract 6 weak-lensing-detected clusters of galaxies. We show that their counts can be used to constrain the power spectrum normalisation $\sigma_8 =0.92_{-0.30}^{+0.26}$ for $\Omega_m=0.24$. We show that despite the large scatter generally observed in the M-T relation derived from lensing masses, tight constraints on both its slope and normalisation $M_*$ can be obtained with a moderate number of sources provided that the covered mass range is large enough. Adding clusters from Bardeau et al. (2007) to our sample, we measure $M_* = 2.71_{-0.61}^{+0.79} 10^{14} h^{-1} M_\odot$. Although they are dominated by shot noise and sample variance, our measurements are consistent with currently favoured values, and set the stage for future surveys. We thus investigate the dependence of those estimates on survey size, depth, and integration time, for joint weak lensing and X-ray surveys. We show that deep surveys should be dedicated to the study of the physics of clusters and groups of galaxies. For a given exposure time, wide surveys provide a larger number of detected clusters and are therefore preferred for the measurement of cosmological parameters such as $\sigma_8$ and $M_*$. We show that a wide survey of a few hundred square degrees is needed to improve upon current measurements of these parameters. More ambitious surveys covering 7000 deg$^2$ will provide the 1% accuracy in the estimation of the power spectrum and the M-T relation normalisations.Comment: MNRAS in press Matches accepted version. References update

'To live and die [for] Dixie': Irish civilians and the Confederate States of America

Around 20,000 Irishmen served in the Confederate army in the Civil War. As a result, they left behind, in various Southern towns and cities, large numbers of friends, family, and community leaders. As with native-born Confederates, Irish civilian support was crucial to Irish participation in the Confederate military effort. Also, Irish civilians served in various supporting roles: in factories and hospitals, on railroads and diplomatic missions, and as boosters for the cause. They also, however, suffered in bombardments, sieges, and the blockade. Usually poorer than their native neighbours, they could not afford to become 'refugees' and move away from the centres of conflict. This essay, based on research from manuscript collections, contemporary newspapers, British Consular records, and Federal military records, will examine the role of Irish civilians in the Confederacy, and assess the role this activity had on their integration into Southern communities. It will also look at Irish civilians in the defeat of the Confederacy, particularly when they came under Union occupation. Initial research shows that Irish civilians were not as upset as other whites in the South about Union victory. They welcomed a return to normalcy, and often 'collaborated' with Union authorities. Also, Irish desertion rates in the Confederate army were particularly high, and I will attempt to gauge whether Irish civilians played a role in this. All of the research in this paper will thus be put in the context of the Drew Gilpin Faust/Gary Gallagher debate on the influence of the Confederate homefront on military performance. By studying the Irish civilian experience one can assess how strong the Confederate national experiment was. Was it a nation without a nationalism

Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.

Antibiotic resistance in bacterial pathogens threatens the future of modern medicine. One such resistant pathogen is methicillin-resistant Staphylococcus aureus (MRSA), which is resistant to nearly all β-lactam antibiotics, limiting treatment options. Here, we show that a significant proportion of MRSA isolates from different lineages, including the epidemic USA300 lineage, are susceptible to penicillins when used in combination with β-lactamase inhibitors such as clavulanic acid. Susceptibility is mediated by a combination of two different mutations in the mecA promoter region that lowers mecA-encoded penicillin-binding protein 2a (PBP2a) expression, and in the majority of isolates by either one of two substitutions in PBP2a (E246G or M122I) that increase the affinity of PBP2a for penicillin in the presence of clavulanic acid. Treatment of S. aureus infections in wax moth and mouse models shows that penicillin/β-lactamase inhibitor susceptibility can be exploited as an effective therapeutic choice for 'susceptible' MRSA infection. Finally, we show that isolates with the PBP2a E246G substitution have a growth advantage in the presence of penicillin but the absence of clavulanic acid, which suggests that penicillin/β-lactamase susceptibility is an example of collateral sensitivity (resistance to one antibiotic increases sensitivity to another). Our findings suggest that widely available and currently disregarded antibiotics could be effective in a significant proportion of MRSA infections.MRC - G1001787/1 MRC - MR/N002660/1 WT098600 HICF-T5-342 MR/S00291X/1 201344/Z/16/Z MR/P007201/

Studying Large and Small Scale Environments of Ultraviolet Luminous Galaxies

Studying the environments of 0.4<z<1.2 UV-selected galaxies, as examples of extreme star-forming galaxies (with star formation rates in the range of 3-30 M_sol/yr), we explore the relationship between high rates of star-formation, host halo mass and pair fractions. We study the large-scale and small-scale environments of local Ultraviolet Luminous Galaxies (UVLGs) by measuring angular correlation functions. We cross-correlate these systems with other galaxy samples: a volume-limited sample (ALL), a Blue Luminous Galaxy sample (BLG) and a Luminous Red Galaxy sample (LRG). We determine the UVLG comoving correlation length to be r_0=4.8(+11.6/-2.4) h^-1 Mpc at =1.0, which is unable to constrain the halo mass for this sample. However, we find that UVLGs form close (separation < 30 kpc) pairs with the ALL sample, but do not frequently form pairs with LRGs. A rare subset of UVLGs, those with the highest FUV surface brightnesses, are believed to be local analogs of high redshift Lyman Break Galaxies (LBGs) and are called Lyman Break Analogs (LBAs). LBGs and LBAs share similar characteristics (i.e., color, size, surface brightness, specific star formation rates, metallicities, and dust content). Recent HST images of z~0.2 LBAs show disturbed morphologies, signs of mergers and interactions. UVLGs may be influenced by interactions with other galaxies and we discuss this result in terms of other high star-forming, merging systems.Comment: 35 pages, 10 Figures, accepted for publication in Ap

A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms

Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but specific protein EM labeling has lacked generally applicable genetically encoded tags for in situ visualization in cells and tissues. Here we introduce “miniSOG” (for mini Singlet Oxygen Generator), a fluorescent flavoprotein engineered from Arabidopsis phototropin 2. MiniSOG contains 106 amino acids, less than half the size of Green Fluorescent Protein. Illumination of miniSOG generates sufficient singlet oxygen to locally catalyze the polymerization of diaminobenzidine into an osmiophilic reaction product resolvable by EM. MiniSOG fusions to many well-characterized proteins localize correctly in mammalian cells, intact nematodes, and rodents, enabling correlated fluorescence and EM from large volumes of tissue after strong aldehyde fixation, without the need for exogenous ligands, probes, or destructive permeabilizing detergents. MiniSOG permits high quality ultrastructural preservation and 3-dimensional protein localization via electron tomography or serial section block face scanning electron microscopy. EM shows that miniSOG-tagged SynCAM1 is presynaptic in cultured cortical neurons, whereas miniSOG-tagged SynCAM2 is postsynaptic in culture and in intact mice. Thus SynCAM1 and SynCAM2 could be heterophilic partners. MiniSOG may do for EM what Green Fluorescent Protein did for fluorescence microscopy