Interaction of Disease, Drugs, and Disposition in Ewing\u27s Sarcoma Patients

Ewing\u27s Sarcoma is a pediatric bone cancer that is highly aggressive, leading to a five year survival rate of not only 30% even with multi-modal treatment protocols. Improved therapeutic options are desperately needed. Our research has focused on the ability of the psychoactive cannabinoid, ajulemic acid, to induce apoptosis and decrease metastatic potential in cells from members of the Ewing Sarcoma family of tumors. Recently, we explored the effects of the naturally-occuring cannabinoid, cannabidiol, on three-dimensional spheroids that mimic the cellular components and microenvironment of Ewing\u27s tumors. We looked at how this treatment affects VEGF, a mediator of angiogenesis, to determine if these cannabinoids work through similar cellular pathways. Data with cannabidiol can then be compared to data collected from ajulemic acid studies to determine if these cannabinoids work through similar cellular pathways

First-Personal Body Aesthetics as Affirmations of Subjectivity

This paper redirects some of the philosophical discussion of sexual objectification. Rather than contributing further to debates over what constitutes objectification and whether it is harmful, I argue that aesthetic experience is a useful tool for resisting objectification. Attending to our embodied experiences provides immediate evidence that we are subjects; aesthetically attending to that evidence is a way of valuing it. I consider the human body as an aesthetic site, then as an ethico-aesthetic site, and finally as a site of resistance. In addition to deepening accounts of body aesthetic experience, this paper helps frame human bodies as integral to moral agency, rather than impediments to it

Transportation for an Aging Population: Promoting Mobility and Equity for Low-Income Seniors

This study explores the travel patterns, needs, and mobility problems faced by diverse low-income, inner-city older adults in Los Angeles in order to identify solutions to their mobility challenges. The study draws information from: (1) a systematic literature review of the travel patterns of older adults; (2) a review of municipal policies and services geared toward older adult mobility in six cities; (3) a quantitative analysis of the mobility patterns of older adults in California using the California Household Travel Survey; and (4) empirical work with 81 older adults residing in and around Los Angeles’ inner-city Westlake neighborhood, who participated in focus groups, interviews, and walkabouts around their neighborhood

Ouachita Department of Theatre Arts to present Hay Fever Nov. 4-8

Ouachita Baptist University’s Department of Theatre Arts will present its fall production, “Hay Fever,” beginning Wednesday, Nov. 4, at 7:30 p.m. in Verser Theatre. Performances will continue Nov. 5-7 at 7:30 p.m., with a matinee performance on Sunday, Nov. 8, at 2:30 p.m. Due to COVID-19, seating is limited to Ouachita students, faculty and staff, but a ticketed livestreaming option will be available at www.obu.edu/boxoffice. Written by Noel Coward, “Hay Fever” is a three-act comedy set in 1920s London. The plot focuses on the self-centered Bliss family, whose eccentricity becomes apparent when each member invites a guest for the weekend. The outsiders’ visit sheds lights on the Bliss’ craziness, eventually driving the guests away

The Two Cultures of Engineering Education:Looking Back and Moving Forward

The prevalent historical model of engineering education is centered on a conception of engineering as a technical discipline. However, engineering students are increasingly expected to develop nontechnical competencies for their workforce preparation and professional responsibility. In particular, ethics is an important outcome of engineering education. Ethics has roots in the humanities and social science (HSS), creating a tension between the technical culture of engineering and its engagement with these disciplines. There is a persistent disconnection between the engineering and HSS cultures, which impacts how ethics is valorised and integrated in the curricula. This chapter explores the dichotomy between how technical and nontechnical learning outcomes are addressed in engineering education and its implications for ethics. Drawing on two studies that were independently designed and conducted in Ireland and the US, this chapter synthesizes the perspectives of educators across the two national contexts. Educators in both countries completed semi-structured interviews to understand their practices and perceptions related to engineering ethics. The interviews uncovered four themes related to the de-prioritization of ethics in engineering education: the weight assigned to ethics in accreditation, the piecemeal integration of ethics in the engineering curriculum, the perceived status of ethics as soft and ancillary, and the lack of faculty training. Based on these findings, the chapter concludes with recommendations to bridge the divide between technical and nontechnical learning outcomes and support the more cohesive and interdisciplinary integration of ethics in engineering education.</p

From colloidal dispersions to colloidal pastesthrough solid–liquid separation processes

Solid–liquid separation is an operation that starts with a dispersion of solid particles in a liquid and removes some of the liquid from the particles, producing a concentrated solid paste and a clean liquid phase. It is similar to thermodynamic processes where pressure is applied to a system in order to reduce its volume. In dispersions, the resistance to this osmotic compression depends on interactions between the dispersed particles. The first part of this work deals with dispersions of repelling particles, which are either silica nanoparticles or synthetic clay platelets, dispersed in aqueous solutions. In these conditions, each particle is surrounded by an ionic layer, which repels other ionic layers. This results in a structure with strong short-range order. At high particle volume fractions, the overlap of ionic layers generates large osmotic pressures; these pressures may be calculated, through the cell model, as the cost of reducing the volume of each cell. The variation of osmotic pressure with volume fraction is the equation of state of the dispersion. The second part of this work deals with dispersions of aggregated particles, which are silica nanoparticles, dispersed in water and flocculated by multivalent cations. This produces large bushy aggregates, with fractal structures that are maintained through interparticle surface– surface bonds. As the paste is submitted to osmotic pressures, small relative displacements of the aggregated particles lead to structural collapse. The final structure is made of a dense skeleton immersed in a nearly homogeneous matrix of aggregated particles. The variation of osmotic resistance with volume fraction is the compression law of the paste; it may be calculated through a numerical model that takes into account the noncentral interparticle forces. According to this model, the response of aggregated pastes to applied stress may be controlled through the manipulation of interparticle adhesion

Pivoting in the pandemic:a qualitative study of child and adolescent psychiatrists in the times of COVID-19

OBJECTIVES: We examined the personal and professional impacts of the COVID-19 pandemic on the development, practice, and shifting values of child and adolescent psychiatrists (CAP), in order to inform how the field may move forward post-pandemic. METHODS: We conducted individual semi-structured interviews of child and adolescent psychiatrists (n = 24) practicing in the United States. Participants were selected as a diverse purposive sample of active members of the American Academy of Child and Adolescent Psychiatry (AACAP). We analyzed anonymized transcripts through iterative coding using thematic analysis aided by NVivo software. RESULTS: We identified three main thematic domains within participants’ response to the pandemic, which have engendered a reevaluation of and a recommitment to the aims of each clinician and the field of CAP more broadly. These domains, paired with representative questions, include: (1) Unsettling, or “who have we been?” (identifying discontents such as daily inefficiencies and intraprofessional loss of trust); (2) Adaptation, or “who are we now?” (exploring affordances and limitations of virtual work, and the evolution of personal and professional identity); and (3) Reimagination, or “who will we become?” (renewing a commitment to psychiatry as advocacy). Even as we identified a collective agreement toward the need for implementing change, just what needs to change, and how that change will be realized, remain contested. CONCLUSION: These three thematic domains, augmented by a national confrontation with race and equity, have engendered a field-wide reckoning with known inequities. They have reinvigorated collective responses and calls to action. The divergent mindsets to change and leadership have provided an aperture for what values and practices the field might instill in its next generation of practitioners. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13034-021-00382-6