51 research outputs found
1079-102 Correlation between norepinephrine and epinephrine myocardial spillover and tumor necrosis factor-alpha in conventional versus off-pump coronary artery bypass surgery
Background: Complete revascularization obtained by coronary artery bypass surgery does not prevent long term left ventricular remodeling and heart failure development. Periprocedural events linked to different surgical techniques, such as cardiopulmonary bypass with cardioplegic arrest (CABG) versus off-pump procedures may trigger an irreversible microvascular dysfunction or myocytes necrosis and apoptosis. Methods: To test this hypothesis we measured norepinephrine and epinephrine coronary sinus and aortic spillover before and after surgery, simultaneously with Tumor Necrosis Factor-alpha (TNF-alpha) measurements in 30 patients randomized to CABG (n=15), or off-pump (n=15) coronary surgery. Plasma catecholamines were assessed by high performance
liquid chromatography and TNF-alpha by ELISA. Results: Norepinephrine and epinephrine spillover was similar in the two groups before surgery, being 1.38\ub10.62 and 1.08\ub10.45, respectively. After surgery norepinephrine spillover was 1.43\ub10.56, 0.72\ub10.49 in CABG and off-pump, respectively (P<0.05 CABG versus off-pump, means \ub1SD ). Epinephrine spillover was 1.27\ub10.16 and 0.65\ub10.15 respectively (P<0.05, CABG versus off-pump). TNF-alpha significantly increased only in CABG patients being 22.17\ub16.79 and 35.4\ub15.98, pg/mL, before and after surgery (P<0.05), respectively. After surgery norepinephrine spillover correlated with TNF-alpha levels (P=0.01, R=0.553). Conclusions: Patients undergoing off-pump interventions showed significantly lower catecholamines spillover as compared to CABG, suggesting that the off-pump technique may result less invasive, not only for a lower local and whole body inflammatory response but also for a lower sympathetic drive. For the first time in humans we have detected an increase in epinephrine-spillover after cardiac surgery. Further studies are necessary to evaluate if the short-term advantages observed after off-pump coronary surgery translate into a long-term attenuation of left ventricular remodeling and in the prevention of heart failure progression
US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report
This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in
Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference
Recommended from our members
Borexino : geo-neutrino measurement at Gran Sasso, Italy
Geo-neutrinos, electron anti-neutrinos produced in beta-decays of naturally occurring radioactive isotopes in the Earth, are a unique direct probe of our planet's interior. After a brief introduction of the geo-neutrinos' properties and of the main aims of their study, we discuss the features of a detector which has recently provided breakthrough achievements in the field, Borexino, a massive, calorimetric liquid scintillator detector installed at the underground Gran Sasso Laboratory. With its unprecedented radiopurity levels achieved in the core of the detection medium, it is the only experiment in operation able to study in real time solar neutrino interactions in the challenging sub-MeV energy region. Its superior technical properties allowed Borexino also to provide a clean detection of terrestrial neutrinos. Therefore, the description of the characteristics of the detected geo-neutrino signal and of the corresponding geological implications are the main core of the discussion contained in this work
US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report
This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017
Recommended from our members
The SOX project: a search for sterile neutrinos with BoreXino
On behalf of the Borexino Collaboration: G. Bellinih, D. Bickq, G. Bonfinie, D. Bravoo, B. Caccianigah, F. Calapricek , P. Cavalcantee, A. Chavarriak , A. Chepurnovp, D. D'Angeloh, S. Davinir , A. Derbinl , A. Etenkog, K. Fomenkob,e, D. Francoa, C. Galbiatik , C. Ghianoa, M. Goger-Neffm, A. Gorettik , C. Hagnerq, E. Hungerfordr , Aldo Iannie, Andrea Iannik , V. Kobychev f , D. Korablevb, G. Korgar , D. Kryna, M. Laubensteine, J.M. Linko, E. Litvinovichg, F. Lombardie, P. Lombardih, L. Ludhovah, G. Lukyanchenkog, I. Machuling, S. Maneckio, W. Maneschgi, E. Meronih, M. Meyerq, L. Miramontih, M. Misiaszekd , P. Mosteirok , V. Muratoval , L. Oberauerm, M. Obolenskya, F. Ortica j , K. Otisn, L. Pappo, A. Pocarn, G. Ranuccih, A. Razetoe, A. Reh, A. Romani j , N. Rossie, R. Saldanhak , C. Salvoc, S. Schonertm, H. Simgeni, M. Skorokhvatovg, O. Smirnovb, A. Sotnikovb, S. Sukhoting, Y. Suvorovs,g, R. Tartagliae, G. Testerac, R.B. Vogelaaro, M. Wojcikd , M. Wurmt , O. Zaimidorogab, S. Zavatarellic, G. Zuzel
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