Studies on the Cell Ni|Ni-Soap(s), K-Soap, Cu-Soap(s)|Cu

60-6

Effect of Ovalbumin, Gelatin & Transfusion Gelatin on Micellization of Non-ionic Surfactants

61

Genetic Correction of Sickle Cell Anemia and β-Thalassemia: Progress and New Perspective

Gene therapy for β-globinopathies, particularly β-thalassemia and sickle cell anemia, holds promise for the future as a definitive corrective approach for these common and debilitating disorders. Correction of the β-globinopathies using lentivirus vectors carrying the β- or γ-globin genes and elements of the locus control region has now been well established in murine models, and an understanding of "what is required to cure these diseases" has been developed in the first decade of the 21st century. A clinical trial using one such vector has been initiated in France with intriguing results, while other trials are under development. Vector improvements to enhance the safety and efficiency of lentivirus vectors are being explored, while new strategies, including homologous recombination in induced pluripotent cells, for correction of sickle cell anemia have shown proof-of-concept in vitro. Here, a review is provided of the current substantial progress in genetic correction of β-globin disorders

Integrated weed management in direct seeded rice in Trans Indo-Gangetic plains of India- A review

In the Indo-Gangetic Plains (IGP) of India, rice (Oryza sativa L.) is taken by conventional tilled puddled transplanted (CT-PTR) method. CT-PTR requires a lot of water (2000-2500 mm) which comes mainly from groundwater. Due to declining water table and changing climate, the sustainability of CT-PTR rice is under immense pressure. The alternative to CT-PTR could be direct seeded rice (DSR) which requires less water, labor, initial cost and energy than CT-PTR. But direct seeded rice is heavily infested with weeds which cause severe loss to the grain yield. Thus, the success of aerobic rice depends on effective and timely weed control. As a single weed control method may not be successful on a long term basis, weed problem in direct seeded rice needs to be solved by integrated approach. Integrating cultural, mechanical and chemical methods along with highly competitive cultivars with effective allelopathic properties, effective weed management on long term sustainable basis can be achieved

Interaction of Cationic Surfactants with Polytungstate

346-34

Interaction of Cationic Surfactants with Polytungstate

346-34

Micellization of Cobalt Hexamrnine Soaps in Methanol-Benzene Mixture

124-12

Effects of a second intron on recombinant MFG retroviral vector

 The retroviral vectors based on an MFG-type backbone have superior expression characteristics, in part, due to the presence of the retroviral chimeric intron (MFG intron). We tested the hypothesis that inclusion of a second intron in MFG vectors may influence packaging and/or LTR-driven transgene expression. We constructed two MFG retroviral vectors, MFG/hFIXc and MFG/hFIXm2, containing human factor IX (hFIX) cDNA without and with a 0.3-kb hFIX intron, respectively. When tested with primary mouse myoblasts or HepG2 cells in culture for transient expression activity, pMFG/hFIXm2 plasmid produced two-to-three fold higher hFIX than pMFG/hFIXc. These vectors produced equivalent retroviral titers from packaging cells. In transduced cells, the splicing of the MFG intron in the retroviral transcripts occured at a similar efficiency; however, MFG/hFIXc virus gave two-fold higher hFIX expression than that of the MFG/hFIXm2 viral infection. Analyses of MFG/hFIXm2 virion RNA and transduced cell genomic DNA suggested that, although the hFIX intron containing viral RNA are packaged, these viruses fail to integrate their transgenes into the genome of transduced cells, suggesting a block at the reverse transcription and/or integration steps. Similar results were also obtained with the prototype vectors, LIXcSN and LIXm2SN, lacking the MFG intron. Together, these results suggest that a hFIX cDNA sequence in the retroviral vectors performs better over hFIX intron-containing minigene.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42460/1/705-146-3-601_11460601.pd

Do energy resources matter for growth level? The dynamic effects of different strategies of renewable energy, carbon emissions on sustainable economic growth

Correction to: Do Energy Resources matter for Growth Level? The dynamic effects of different strategies of renewable energy, carbon emissions on sustainable economic growth (Clean Technologies and Environmental Policy, (2022), 10.1007/s10098-022-02432-9) - 2-s2.0-85144909701This study examines the association between renewable energy strategies and carbon emissions on sustainable economic growth under affordable and clean energy sources to achieve sustainable development goal seven. This research provides new insight by exploring the nexus between environmental pollution and the creation of numerous bases of renewable energies, such as hydropower, wind power, biomass, geothermal, and solar photovoltaic, and economic growth epitomizing capital, trade openness, and government spending. Moreover, this investigation uses second-generation devices for econometric investigation and a heterogeneous methodology for panel data for selected Asian countries. The empirical exploration of long-term influences drove by the Common Correlated Effects Mean Group, close by Augmented Mean Group and Mean Group assessors confirm the positive and significant influence of renewable energy like hydropower, solar photovoltaic, wind, biomass, and geothermal on the economic growth of Asian economies. Study findings provide valuable insights for all stakeholders in an integrated and coherent manner

Malignant peripheral nerve sheath tumors (MPNST) – Clinicopathological study and treatment outcome of twenty-four cases

BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is biologically an aggressive tumor for which the treatment of choice is the surgery. We reviewed the clinical profile, diagnostic methods, treatment patterns, and outcome of twenty-four MPNST patients in this study. PATIENTS AND METHODS: A retrospective analysis of 24 MPNST patients, treated from 1994 to 2002, in the department of Surgical Oncology at All India Institute of Medical Sciences, New Delhi, was done. A combination of gross, histopathological and immunohistochemical findings, and proliferation markers (MIB1) were considered for diagnosis and grade of the MPNST. Survival analysis was done by the Kaplan-Meier method and differences were evaluated with the log-rank test. Multivariate analysis was carried out by using Cox's proportional hazards model by using SPSS (Version 9, Chicago, Illinois) software. RESULTS: MPNST constituted 12% of all soft tissue sarcomas, where 21% (5/24) of patients had associated Von Recklinghausen's disease (VRHD). A higher incidence of male preponderance and multifocal MPNST were noted in the present series. At a mean follow-up of 38 months, 13 (54 %) patients had relapse of disease and 5-year over all and disease free survival were 58% and 35% respectively. In univariate analysis, sex (p = 0.05), tumor depth (p < 0.03), and cellular differentiation (p < 0.002) were shown to be adverse prognostic factors for disease free survival and sex (p = 0.04), cellular differentiation (p < 0.0004), and tumor grade (p = 0.05) for overall survival. However, in multivariate analysis, cellular differentiation (p < 0.005) and tumor grade (p < 0.01) emerged as independent prognostic factors for both disease free and overall survival, respectively. Postoperative radiotherapy (RT) has shown a definite role in both disease free and overall survival in this study. CONCLUSION: MPNSTs constituted a significant proportion (12%) of soft tissue sarcoma in our medical center. Heterogeneous differentiation and multifocality of the tumor were few distinct features of MPNST. Sex and cellular differentiation were noticed as the new adverse prognostic factors and adjuvant radiotherapy has been proved to be a significant treatment tool in the current series