32 research outputs found
The effect of mercury chloride and methyl mercury on brain microsomal Na<sup>+</sup>-K<sup>+</sup>-ATPase after partial delipidisation with Lubrol<sup>®</sup>.
The microsomal Na+-K+-ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 × 10-7 M for mercury chloride and 3.5 × 10-6 M for methyl mercury. The inhibition was of a non-competetive type with respect to ATP. The non-ionic detergent LubrolrG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials
Effect of Cadmium and Copper on Monoamine Oxidase Type A and B in Brain and Liver Mitochondria
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