5,183 research outputs found
Design approaches in technology enhanced learning
Design is a critical to the successful development of any interactive learning environment (ILE). Moreover, in technology enhanced learning (TEL), the design process requires input from many diverse areas of expertise. As such, anyone undertaking tool development is required to directly address the design challenge from multiple perspectives. We provide a motivation and rationale for design approaches for learning technologies that draws upon Simon's seminal proposition of Design Science (Simon, 1969). We then review the application of Design Experiments (Brown, 1992) and Design Patterns (Alexander et al., 1977) and argue that a patterns approach has the potential to address many of the critical challenges faced by learning technologists
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ESTABLISHING A LOCAL BANK AND COMPARING EFFICACIES OF THIRD PARTY VIRUS-SPECIFIC CYTOTOXIC T CELLS (VST) AND CYTOKINE INDUCED KILLER CELLS (VSCIK)
Short- and long-term conditioning of a temperate marine diatom community to acidification and warming
Ocean acidification and greenhouse warming will interactively influence competitive success of key phytoplankton groups such as diatoms, but how long-term responses to global change will affect community structure is unknown. We incubated a mixed natural diatom community from coastal New Zealand waters in a short-term (two-week) incubation experiment using a factorial matrix of warming and/or elevated pCO2 and measured effects on community structure. We then isolated the dominant diatoms in clonal cultures and conditioned them for 1 year under the same temperature and pCO2 conditions from which they were isolated, in order to allow for extended selection or acclimation by these abiotic environmental change factors in the absence of interspecific interactions. These conditioned isolates were then recombined into ‘artificial’ communities modelled after the original natural assemblage and allowed to compete under conditions identical to those in the short-term natural community experiment. In general, the resulting structure of both the unconditioned natural community and conditioned ‘artificial’ community experiments was similar, despite differences such as the loss of two species in the latter. pCO2 and temperature had both individual and interactive effects on community structure, but temperature was more influential, as warming significantly reduced species richness. In this case, our short-term manipulative experiment with a mixed natural assemblage spanning weeks served as a reasonable proxy to predict the effects of global change forcing on diatom community structure after the component species were conditioned in isolation over an extended timescale. Future studies will be required to assess whether or not this is also the case for other types of algal communities from other marine regimes
Dynamics of a Vortex in a Trapped Bose-Einstein Condensate
We consider a large condensate in a rotating anisotropic harmonic trap. Using
the method of matched asymptotic expansions, we derive the velocity of an
element of vortex line as a function of the local gradient of the trap
potential, the line curvature and the angular velocity of the trap rotation.
This velocity yields small-amplitude normal modes of the vortex for 2D and 3D
condensates. For an axisymmetric trap, the motion of the vortex line is a
superposition of plane-polarized standing-wave modes. In a 2D condensate, the
planar normal modes are degenerate, and their superposition can result in
helical traveling waves, which differs from a 3D condensate. Including the
effects of trap rotation allows us to find the angular velocity that makes the
vortex locally stable. For a cigar-shape condensate, the vortex curvature makes
a significant contribution to the frequency of the lowest unstable normal mode;
furthermore, additional modes with negative frequencies appear. As a result, it
is considerably more difficult to stabilize a central vortex in a cigar-shape
condensate than in a disc-shape one. Normal modes with imaginary frequencies
can occur for a nonaxisymmetric condensate (in both 2D and 3D). In connection
with recent JILA experiments, we consider the motion of a straight vortex line
in a slightly nonspherical condensate. The vortex line changes its orientation
in space at the rate proportional to the degree of trap anisotropy and can
exhibit periodic recurrences.Comment: 19 pages, 6 eps figures, REVTE
Outpatient-Based Therapy of Oral Fludarabine and Subcutaneous Alemtuzumab for Asian Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
Background. Intravenous alemtuzumab and fludarabine are effective in combination for the treatment of chronic lymphocytic leukemia (CLL), but require hospital visits for intravenous injection. We performed a pilot study to assess the safety and efficacy of outpatient-based oral fludarabine with subcutaneous alemtuzumab (OFSA) for the treatment of relapsed/refractory CLL. Results. Depending on their response, patients were given two to six 28-day cycles of subcutaneous alemtuzumab 30 mg on days 1,3, and 5 and oral fludarabine 40 mg/m2/day for 5 days. Median patient age was 74. The lymphocyte counts of all five patients fell after the 1st cycle of treatment and reached normal/low levels on completion of 2 to 6 cycles of therapy. Platelet counts and hemoglobin were unaffected. All five patients achieved complete hematological remission, while two attained minimal residual disease negativity on 4-color flow cytometry. Conclusions. Our OFSA regimen was effective in elderly Asian patients with relapsed/refractory CLL, and it should be investigated further
In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment
The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum
efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and
is of significant interest for future dark matter and neutrino experiments
where high signal yields are needed.
We report on the methods developed for in-situ characterization and
monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of
typical measured single-photoelectron charge distributions, correlated noise
(afterpulsing), dark noise, double, and late pulsing characteristics. The
characterization is performed during the detector commissioning phase using
laser light injected through a light diffusing sphere and during normal
detector operation using LED light injected through optical fibres
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