Osteonecrosis of the Jaw After Bisphosphonates Treatment in Patients with Multiple Myeloma

Bone lytic lesion in Multiple myeloma are the most commonly presented symptoms which require treatment with bisphosphonates (BPs). BPs are providing supportive care, reducing the rate of skeletal morbidity but evidently not abolishing it, the criteria for stopping their administration have to be different from those used for classic antineoplastic drugs, and they should not be stopped when metastatic bone disease is progressing. Osteonecrosis of the jaw (ONJ) has been associated recently with the use of BPs. The aim of these study is to evaluate the incidence of ONJ in patients with MM treated with mixed biphosphonates. We analyzed total 296 myeloma patients (150 male and 146 female). Mostly effected age group with 58,1% is age more than 60 years up to 88 years, diagnosed in our institution in the period 2005-2015. We used intravenous or oral forms of biphosphonates such as pamidronate, ibandronate, clodronate and zolendronic acid. The patients were evaluated for ONJ. The incidence of ONJ in our group of patients treated with Bps was 4,6% from our group of 260 patients 87,8% received BPs therapy and patients which haven’t received BPs 12,2%. From this group, 95,4% (248) didn’t show ONJ, and 4,6% (12) showed ONJ. The period of this treatment with BPs is an important risk factor for development of ONJ, average duration of BPs therapy in patients which show adverse effects is 26.8±13.7 months, from the total number of 12 patients that developed ONJ adverse effects, we have 8 patients which received treatment with Zolendronic acid and the remaining 4 patients which were treated with other BPs combinations without Zolendronic acid. All patients treated for MM must continue with the therapy with Zolendronic acid and Pamidronate, each patient must be individually treated according to his response of the treatment (dose, frequency and duration of therapy)

Additional file 6: Table S5. of Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae

Bivariate correlations among variables. (DOCX 13 kb

How political geography can challenge dubious socio-spatial practices: developing transcendental phronetic political geography

Although an increasing number of donors try to improve the living conditions of inhabitants in informal urban settlements, some studies show that only a very limited amount of provided resources reach those impoverished. The inability of projects to change the situation for the better could point to dubious practices. Despite academia trying to produce socially relevant work, it has failed to translate its criticism into actions at the substantive level. Researchers are perturbed from engaging because of meta-theoretical concerns in regard to normativity, among others. The study scrutinises this dilemma and proposes a solution. It recon- siders the core of critical realism and enhances its metaphysical accounts with epistemological ones from both phronetic social science and the French school of géopolitiques. It argues that political geography can challenge dubious practices in the socio-spatial world without losing neither philosophical nor scienti c rigour. The ideas are assessed in a short study on a development project in Cairo, Egypt, demonstrating their applicability and usefulness. Keywords: philosophy of science - critical realism - phronetic social science - phronesis - Yves Lacoste - géopolitiques - power - space - scale - justice - normativity - poverty reductio

Additional file 10: Table S8. of Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

Methylation level, proportion unmethylated, and methylated (>10 %) CpG sites across chromosomes in male validation dataset. (XLSX 11 kb

Additional file 20: Table S13. of Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

GO terms and KEGG pathways enriched for ASE. (XLSX 10 kb

La Croix du Nord : supplément régional à la Croix de Paris ["puis" grand journal quotidien du Nord de la France]

05 août 19111911/08/05 (A22,N7581).Appartient à l’ensemble documentaire : NordPdeC

Additional file 21: Figure S8. of Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

Same directional gene expression changes across tissues in the adult female Duroc and validation datasets. Expression differences of the 10 most up- and downregulated genes between each tissue comparison from the adult female Duroc compared to the differences observed for the same genes in the validation dataset. a Log2 fold change differences in expression between liver and spleen, b liver and muscle, and c spleen and muscle. d Correlation between log2 fold changes in the adult female Duroc and validation dataset for all 3 tissue comparisons. (PNG 9535 kb

Additional file 2: Table S2. of Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

Validation dataset RRBS and RNA-seq read depths. (XLSX 8 kb

Additional file 4: Table S3. of Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

CpG site coverage and methylation level in relation to genomic features. * denotes percent of sites covered out of total in size fraction. (XLSX 11 kb

Additional file 9: Table S7. of Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

Proportion of methylated (>10 %) CpG sites across chromosomes. (XLSX 11 kb