6 research outputs found
Cardiologist Training through the Residency System: a Proposal of the Teaching Area of SAC
Residency is an in-service training system, based on supervised and evaluated scheduled activities. A residency program totrain cardiologists must necessarily meet some conditions: it should be inserted in a healthcare establishment duly authorizedby a competent authority and have equipment and trained human resources interested in teaching. The program must beformalized in a written document specifying professional skills to be achieved, practical activities and evaluation instances.Likewise, the document should detail working administrative conditions (workload, scholarship/salary, insurance and otherrights and responsibilities).Training in Cardiology requires four years: the first year dedicated to Internal Medicine with two months in Intensive Care,and three years in Cardiology. It must necessarily include an Advanced Cardiac Life Support (ACLS) course implementedaccording to the American Heart Association regulations.The residency program structure is based on rotations in the various areas of the Cardiology service; the resident participatesin Continuing Education activities developed in the service (forums, rounds, seminars). It must include formative andcumulative evaluations using tools as the mini-CEX, clinical case discussions (CCD) and direct observation of procedures(DOP), and in all cases a constructive feedback should be provided. It is recommended to complement service training with apostgraduate course so that a specialist degree is achieved at the end of the residency after having fulfilled all the instancesof the evaluation process.La residencia es un sistema de entrenamiento en servicio que se basa en actividades programadas, supervisadas y evaluadas.Un programa de residencia para la formación de cardiólogos debe reunir necesariamente algunas condiciones: estar insertoen un establecimiento asistencial debidamente habilitado por autoridad competente y contar con equipamiento y recursoshumanos capacitados e interesados en la docencia. El programa debe estar formalizado en un documento escrito en el quese detallen las competencias profesionales a lograr, las actividades y prácticas y las instancias de evaluación. Asimismo, en eldocumento se deben explicitar las condiciones administrativas/laborales (carga horaria, beca/salario, seguros y otros derechosy responsabilidades del residente).La formación en Cardiología requiere cuatro años: el primero dedicado a Clínica Médica con dos meses en Cuidados Intensivosy tres años de Cardiología. Obligatoriamente debe incluir el curso de Reanimación Cardiopulmonar Avanzada (ACLS)implementado de acuerdo con las normas de la American Heart Association.El programa de la residencia se estructura con base en las rotaciones por los distintos sectores del servicio; el residente participaen las actividades de Educación Continua que se desarrollan en el servicio (ateneos, pases, jornadas). Se deben incluirevaluaciones formativas y sumativas utilizando instrumentos como el mini-CEX, la discusión de casos clínicos (DCC) y laobservación directa de procedimientos (ODP) y en todos los casos se debe realizar una devolución constructiva (feedback).Es recomendable articular la formación en servicio con un posgrado universitario de manera que al finalizar la residencia yhabiendo cumplido todas las instancias de evaluación se alcance el título universitario de especialista.
Evaluación de la habilidad en la lectura crítica en residentes de cardiología
Background: In recent years there has been a strong emergence of the outcome-based education concept emphasizing the benefit of clearly establishing the professional capabilities to be achieved. Current regulations specify the ability to interpret the results of a research and make a critical reading of scientific publications as one of the cardiologist’s competencies. Objective: The aim of this study was to investigate the capacity of residents to interpret the statistical tests most frequently used in research studies. Method: A questionnaire of 17 multiple-choice questions, developed and validated by Pizarro et al. was used. The maximum possible score was 17 points. Four levels of critical reading skills were established according to the number of correct answers: none (less than 5 points), deficient (between 5 and 9 points), good (between 10 and 14 points) and very good (15 points or more). Results: In May 2016, 169 cardiology residents answered the questionnaire anonymously and voluntarily. In 29% of cases they mentioned previous training in the subject and 88% of them said that bibliographic meetings are regularly carried out in the residency. - Range of correct answers: 0-15. - Mean: 7.56±1.66. - Median: 7 (interquartile range 4-8.5). - Cronbach: 0.81. On average, 44% of the questionnaire was answered correctly, with no significant differences between men and women (45% vs. 43%, p=0.34) or between those who had or did not have previous statistics training (45% vs. 43%, p=0.39). A significant difference was found between Argentine and foreign university graduates (45% vs. 36%, p <0.045). Conclusions: In 73% of the residents, the level of necessary knowledge to interpret research studies was unsatisfactory. The results are similar to those of other published studies. It would be interesting to review teaching strategies and analyze their effectiveness.Introducción: En los últimos años ha surgido con fuerza el concepto outcome-based education que enfatiza la conveniencia de establecer con claridad las competencias profesionales a lograr. En la normativa vigente se especifica la habilidad para interpretar los resultados de la investigación y hacer una lectura crítica de las publicaciones científicas como una de las competencias del médico cardiólogo Objetivo: Indagar la capacidad de los residentes para interpretar las pruebas estadísticas más frecuentemente utilizadas en los trabajos de investigación. Material y métodos: Cuestionario de 17 preguntas de selección múltiple, desarrollado y validado por Pizarro y colaboradores. Puntaje máximo posible 17 puntos. Se establecieron 4 niveles de dominio de la habilidad para la lectura crítica según cantidad de respuestas correctas: ninguna (menos de 5 puntos), insuficiente (entre 5-9 puntos), bueno (entre 10-14 puntos) muy bueno (15 y más). Análisis estadístico: pruebas para datos continuos o categóricos según correspondiera. Resultados: 169 residentes de Cardiología respondieron el cuestionario de forma anónima y voluntaria. 29% menciona formación previa en el tema, 88% dice que en la residencia se realizan regularmente ateneos bibliográficos. • Rango de respuestas correctas: 0 -15. • Promedio: 7,56 ± 1.66. • Mediana 7 (intervalo intercuartil 4 - 8.5). • Cronbach: 0,81. En promedio se respondió correctamente el 44% del cuestionario. Sin diferencias significativas entre hombres y mujeres (45% vs 43%, p=0,34) ni entre los que sí y los que no tenían formación previa en estadística (45% vs. 43% p=0,39). Diferencia significativa entre egresados de universidad argentina o extranjera (45 % vs 36 %, p<0.045). Conclusión: 73% de los residentes mostraron un nivel insuficiente de conocimientos. Resultados similares a los de otros estudios publicados. Sería interesante revisar las estrategias de enseñanza y analizar el grado de eficacia de las mismas
Evaluation of the Level of Knowledge in Basic Areas in Postgraduate Cardiology Education
Background In our country, training in cardiology is achieved by participating in residency programs, attending a hospital cardiology unit or taking university courses. On the basis of comments from teachers giving classes in the SAC Biennial Course about certain kind of deficit in basic areas of the specialty among cardiology residents attending the course, we decided to investigate their knowledge in cardiovascular anatomy, physiology, physical diagnosis, pharmacology and clinical cardiology after 1 or 2 years of training in Internal Medicine or Cardiology residency programs, respectively.ObjectiveTo evaluate the knowledge in basic areas in cardiology among residents attending the UBA Biennial Cardiology Course given by the Argentine Society of Cardiology.(full abstract in pdf)Introducción La formación de especialistas en Cardiología en nuestro país se realiza fundamentalmente a través del sistema de Residencias Médicas o de Concurrencia a un servicio de la especialidad y a través de los Cursos Universitarios. Tomando en cuenta la apreciación de docentes invitados para el dictado de las clases del Curso Bienal de la SAC sobre cierto déficit en la formación en áreas básicas de la especialidad que tendrían los residentes, se decidió realizar un estudio para evaluar los conocimientos en anatomía, fisiología, semiología, clínica y farmacología cardiovascular de los residentes que inician su formación teórica sistemática en la Sociedad Argentina de Cardiología después de un año de residencia en Clínica Médica y uno o dos años de residencia en Cardiología.ObjetivoEvaluar el nivel de conocimientos en áreas básicas de Cardiología de los residentes que iniciaban la carrera de Especialista en Cardiología de la UBA y que concurrían al Curso Bienal dictado en la Sociedad Argentina de Cardiología.(resumen completo en pdf
Maltrato en la formación médica: situación en las residencias de cardiología
Background: Mistreatment is defined as the behavior that makes another person feel hurt, undervalued or incompetent. A
certain level of intimidation and humiliation during training was considered necessary to prepare the doctor for a difficult
profession. The conditions in which medical residences and professional practice are developed today generate a high prevalence of burnout.
Objective: The aim of this study was to investigate the perception that Cardiology residents have on the mistreatment received
and if they acknowledge having incurred in any aggravating behavior.
Methods: A survey was conducted in residents attending the Biannual Cardiology Course of the Argentine Society of Cardiology.
Results: A total of 183 residents responded the survey and all of them (100%) reported some type of mistreatment. Being
humiliated for making a mistake and shouted at were the most frequently mentioned forms of mistreatment from a senior
resident, a patient or their relatives. Almost half of the residents (46%) said they had been mistreated by the nursing staff.
while 33.5% acknowledged having incurred in aggravating situations directed against another resident, a staff doctor and/
or another specialty physician.
Discussion: The results are similar to other studies already published. For the safety of patients and the health of physicians, it
is recommended to include strategies for coping with stress and it is considered essential to promote cultural changes within
academic and care institutions aimed at creating more democratic and healthier working environments.Introducción: El maltrato se define como el comportamiento que hace que otra persona se sienta herida, desvalorizada o
incompetente. Un cierto nivel de intimidación y humillación durante la formación se consideraba necesario para preparar al
médico para una profesión difícil. Las condiciones en las que hoy se desarrollan las residencias médicas y la práctica profesional
generan una alta prevalencia de burnout (agotamiento).
Objetivo: Indagar la percepción que tienen los residentes de Cardiología sobre maltrato recibido y si reconocen haber incurrido
en alguna conducta agraviante.
Material y Métodos: Encuesta aplicada a residentes que asisten al Curso Bianual de Cardiología de la Sociedad Argentina
de Cardiología
Resultados:Respondieron 183 residentes. El 100% dijo haber recibido algún tipo de maltrato. Ser humillado por un error
cometido y los gritos, son las formas de maltrato mencionadas con mayor frecuencia; un residente superior, un paciente y/o
sus familiares fueron señalados como los responsables de las agresiones recibidas. Casi la mitad de residentes (46%) dijeron
haber sido maltratados por el personal de enfermería. El 33,5% reconoció haber incurrido en situaciones de maltrato y que
éste estuvo dirigido a otro residente, a un médico de planta y/o un médico de otra especialidad.
Discusión: Los resultados son similares a otros estudios ya publicados. Por la seguridad de los pacientes y por la salud de los
médicos se recomienda incluir en la formación profesional las estrategias para el afrontamiento del estrés y se considera
indispensable promover un cambio cultural dentro de las instituciones académicas y asistenciales orientado a crear espacios
de trabajo más democráticos y más saludables
2010-2017 Evaluation and Accreditation of Cardiology Residencies
Introducción: El Ministerio de Salud y Desarrollo Social de la Nación implementa un Sistema Nacional de Acreditación de Residencias del Equipo de Salud. La Sociedad Argentina de Cardiología (SAC) participa como entidad evaluadora de los programasde residencias médicas en cardiología.Objetivo: El propósito del presente trabajo es presentar los resultados del proceso de evaluación y acreditación de residencias de Cardiología.Material y métodos: Revisión documental de los informes elevados por los pares evaluadores designados por la SAC y de los dictámenes del Ministerio publicados en el Boletín Oficial entre 2010 y 2017.Resultados: Se revisaron 37 informes elaborados por los pares evaluadores, se identificaron fortalezas y debilidades. Fortaleza destacada: supervisión continua recibida por los residentes. Debilidad: escaso tiempo dedicado a la atención de pacientes ambulatorios. Se revisaron 28 dictámenes del Ministerio, se analizaron las recomendaciones más frecuentes: incorporación de contenidos transversales, regulación de la cantidad de guardias, de su duración y de la organización del descanso posguardia.Conclusiones: Si bien a primera vista parece que ambas instituciones tienen distintos criterios a la hora de acreditar unprograma de formación en servicio, en realidad, se trata de miradas complementarias que coinciden en los siguientes aspectos:importancia de la supervisión, necesidad de sistematizar la evaluación del desempeño de los residentes y necesidad deincrementar la producción de trabajos científicos y la participación de los residentes en aquellos. También se encontró un alto grado de coincidencia entre la sugerencia de la SAC y el dictamen del Ministerio en relación con la categoría y los años de acreditación que merecía cada programa evaluado.Background: The National Ministry of Health and Social Development implements a National System of Accreditation ofHealth Team Residencies. The Argentine Society of Cardiology (SAC) participates as an evaluation entity of the medicalresidency programs in cardiology.Objective: The purpose of this study is to present the results of the evaluation process and accreditation of cardiology residencies.Methods: This was a documentary review of the reports submitted by the peer reviewers appointed by SAC and the opinionsof the Ministry of Health in the Official Gazette between 2010 and 2017.Results: Thirty-seven reports prepared by peer reviewers were analyzed and strengths and weaknesses were identified. Outstandingstrength: continuous supervision received by residents. Weakness: time spent on outpatient care. Twenty-eight Ministryof Health opinions were reviewed and the most frequent recommendations were analyzed: incorporation of transversalcontents; regulation of number of on-call duties, their duration and the organization of the rest period after on-call shifts.Conclusions: Although both institutions seem initially to have different criteria when accrediting a health service trainingprogram, in reality, they have complementary views which coincide in the following aspects: importance of supervision; needto systematize the evaluation of residents’ performance; and need to increase the number of scientific works with residentparticipation. A high degree of coincidence was also obtained between SAC’s suggestion and the opinion of the Ministry ofHealth, in relation to the category and years of accreditation that each evaluated program deserved
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7th Drug hypersensitivity meeting: part two
Table of contents Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101) P92 16 years of experience with proton pump inhibitors (PPIs) Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez P93 Allergy evaluation of quinolone induced adverse reactions Jaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De Rojas P94 Bupropion-induced acute urticaria and angioedema, a case report Emre Ali Acar, Ayse Aktas, Aylin Türel Ermertcan, Peyker Temiz P96 Delayed type hypersensitivity and study of cross-reactivity between proton-pump inhibitors Chien-Yio Lin, Chung-Yee Rosaline Hui, Ya-Ching Chang, Chih-Hsun Yang, Wen-Hung Chung P97 Diagnostic work-up in suspected hypersensitivity to proton-pump inhibitors: looking at cross-reactivity Fabrícia Carolino, Diana Silva, Eunice Dias De Castro, Josefina R. Cernadas P98 Management of infusion-related hypersensitivity reactions to enzyme replacement therapy for lysosomal diseases Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Alex Lacerda, Ana Maria Martins, Ekaterini Goudouris, Marcia Ribeiro, José Francisco Da Silva Franco, Leandra Queiroz, Dirceu Solé P99 Management of insulin allergy with continuous subcutaneous insulin infusion Ceyda Tunakan Dalgiç, Aytül Zerrin Sin, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Ali Kokuludag P100 Off-label use of icatibant for management of serious angioedema associated with angiotensin inhibitors Ana M. Montoro De Francisco, Talía Mª De Vicente Jiménez, Adriana M. Mendoza Parra, Angella M. Burgos Pimentel, Amelia García Luque P101 Thiocolchicoside anaphylaxis: an unusual suspect? Luis Amaral, Fabricia Carolino, Leonor Carneiro Leão, Eunice Castro, Josefina Cernadas Poster walk 12: betalactam hypersensitivity (P102–P111) P102 A curious delayed reading: a case report of a β-lactam allergy in a child Nicole Pinto, Joana Belo, João Marques, Pedro Carreiro-Martins, Paula Leiria-Pinto P103 Betalactam-induced hypersensitivity: a 10-years’ experience Amel Chaabane, Haifa Ben Romdhane, Nadia Ben Fredj, Zohra Chadly, Naceur A. Boughattas, Karim Aouam P104 Cefazolin hypersensitivity: towards optimized diagnosis Astrid P. Uyttebroek, Chris H. Bridts, Antonino Romano, Didier G. Ebo, Vito Sabato P105 Clavulanic acid allergy: two cases report Anabela Lopes, Joana Cosme, Rita Aguiar, Tatiana Lourenço, Maria-João Paes, Amélia Spínola-Santos, Manuel Pereira-Barbosa P106 Diagnosis of betalactam allergy in an allergy department Cíntia Rito Cruz, Rute Pereira Dos Reis, Elza Tomaz, Ana Paula Pires, Filipe Inácio P107 Diagnostic work-up of 410 patients with suspicion of betalactam antibiotic hypersensitivity Filipe Benito-Garcia, Inês Mota, Magna Correia, Ângela Gaspar, Marta Chambel, Susana Piedade, Mário Morais-Almeida P108 Immediate selective hypersensitivity reactions to clavulanic acid Alla Nakonechna, Yurij Antipkin, Tetiana Umanets, Fernando Pineda, Francisca Arribas, Volodymyr Lapshyn P109 Prevalence and incidence of penicillin hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P110 Selective sensitization to amoxicilin and clavulanic acid Jose Julio Laguna Martinez, Aranzazu Jimenez Blanco, Javier Dionicio Elera, Cosmin Boteanu, Rosario Gonzalez-Mendiola, Marta Del Pozo P111 Infliximab-specific T cells are detectable also in treated patients who have not developed anti-drug antibodies Alessandra Vultaggio, Francesca Nencini, Sara Pratesi, Andrea Matucci, Enrico Maggi Poster walk 13: biologicals, local anesthetics, others (P112–P118) P112 A case report of allergic immediate systemic reaction to adalimumab and certolizumab Ceyda Tunakan Dalgiç, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Aytül Zerrin Sin, Ali Kokuludag P113 Allergy to local anesthetics: negative predictive value of skin tests Ivana Cegec, Danica Juricic Nahal, Viktorija Erdeljic Turk, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iva Kraljickovic, Iveta Simic P114 Cutaneous adverse reactions of molecular targeted agents: a retrospective analysis in 150 patients in our department Yukie Yamaguchi, Tomoya Watanabe, Megumi Satoh, Tomohiko Tanegashima, Kayoko Oda, Hidefumi Wada, Michiko Aihara P115 Generalized paralysis induced by local lidocaine injection Jaechun Jason Lee, Jay Chol Choi, Hwa Young Lee P116 Hypersensitivity to local anaesthetics: a 10 year review Rosa-Anita Rodrigues Fernandes, Emília Faria, Joana Pita, Nuno Sousa, Carmelita Ribeiro, Isabel Carrapatoso, Ana Todo Bom P117 Local anaesthetics: a rare culprit in hypersensitivity reactions Ana Rodolfo, Eunice Dias-Castro, Josefina Cernadas P118 Stevens–Johnson syndrome in clinical practice: a variant of clinical course Marina Voronova Poster walk 14: RCM (P119–P128) P119 13 cases of severe anaphylactic reactions due to radiocontrast media Jaume Martí Garrido, Ramon Lopez Salgueiro, Diana Kury Valle, Verónica Pacheco Coronel, Carolina Perales Chordá, Dolores Hernandez Fernandez De Rojas P120 Anaphylactic shock after administration of iodinated contrast medium during cardiac catheterization Roselle Catherine Yu Madamba, Marta Ferrer, Maria Jose Goikoetxea, Carmen D’Amelio, Amalia Bernad, Olga Vega, Gabriel Gastaminza P121 Anaphylactic shock and cardiac arrest induced by gadolinium-based contrast agents Beatriz Pola Bibián, Marina Lluncor Salazar, Gemma Vilà Nadal, Ana María Fiandor Roman, Javier Dominguez Ortega, Miguel Gonzalez Muñoz, Santiago Quirce Gancedo, Maria Rosario Cabañas Moreno P122 Anaphylaxis to gadobenate and cross-reactivity to other gadolinium-based contrast agents in two patients Kathrin Scherer Hofmeier P123 Anaphylaxis to glatiramer acetate in a patient with multiple sclerosis Fabrícia Carolino, Vladyslava Barzylovych, Josefina R. Cernadas P124 Delayed hypersensitivity reaction to radiocontrast media Fabrícia Carolino, Diana Silva, Leonor Leão, Josefina R. Cernadas P125 Drug reaction with eosinophilia and systemic symptoms induced by iodixanol Gemma Vilà-Nadal, Beatriz Pola, Marina Lluncor, Ana Fiandor, Teresa Bellón, Javier Domínguez, Santiago Quirce P126 Electronic consultation support system for radiocontrast media hypersensitivity changes clinician’s behavior Min-Suk Yang, Sun-Sin Kim, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Yoon-Seok Chang P127 Hypersensitivity reactions to iodinated contrast media: skin testing and follow-up Danica Juricic Nahal, Ivana Cegec, Viktorija Erdeljic Turk, Iva Kraljickovic, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iveta Simic P128 Would iodine allergy exist? Clémence Delahaye, Jenny Flabbee, Julie Waton, Olivia Bauvin, Annick Barbaud Poster walk 15: MPE/type 4 (P129–P137) P129 Delayed hypersensitivity cutaneous reactions: a case/control study from a tunisian database Karim Aouam, Najah Ben Fadhel, Zohra Chadly, Nadia Ben Fredj, Naceur A. Boughattas, Amel Chaabane P130 Delayed hypersensitivity reactions to cephalosporins: a review of seven cases Joana Cosme, Anabela Lopes, Amélia Spínola-Santos, Manuel Pereira-Barbosa P131 Diclofenac induced allergic contact dermatitis: case series of four patients Sandra Jerkovic Gulin, Anca Chiriac P132 Late-onset maculopapular rash to irbesartan Bárbara Kong Cardoso, Elza Tomaz, Regina Viseu, Filipe Inácio P133 Nonimmediate hypersensitivity reactions to betalactams: a retrospective analysis Ana Moreira, Susana Cadinha, Ana Castro Neves, Patricia Barreira, Daniela Malheiro, J. P. Moreira Da Silva P134 Occupational airborne contact dermatitis to omeprazole Ružica Jurakic-Toncic, Suzana Ljubojevic, Petra Turcic P135 Ornidazole-induced fixed drug eruption confirmed by positive patch test on a residual pigmented lesion Liesbeth Gilissen, Sara Huygens, An Goossens P136 Repeated delayed reaction induced by amoxicillin and amoxicillin clavulanate Inmaculada Andreu, Ramon Lopez-Salgueiro, Alicia Martinez Romero, Pau Gomez Cabezas P137 Systemic photosensitivity from fenofibrate in a patient photo-sensitized to ketoprofen Liesbeth Gilissen, An Goossens Poster walk 16: HLA genetics (P138–P146) P138 A copy number variation in ALOX5 and PTGER1 is associated with nonsteroidal anti-inflammatory drugs induced urticaria and/or angioedema Pedro Ayuso Parejo, Maria Del Carmen Plaza-Serón, Inmaculada Doña, Natalia Blanca López, Carlos Flores, Luisa Galindo, Ana Molina, James Richard Perkins, Jose Antonio Cornejo-García, José Augusto García-Agúndez, Elena García-Martín, Paloma Campo, María Gabriela Canto, Miguel Blanca P139 Association of galectin-3 (LGALS3) single nucleotide polymorphisms with non-steroidal anti-inflammatory drugs-induced urticaria/angioedema José Antonio Cornejo-Garcia, Inmaculada Doña, Rosa María Guéant-Rodríguez, Natalia Blanca-López, María Carmen Plaza-Serón, Raquel Jurado-Escobar, Esther Barrionuevo, María Salas, María Luisa Galindo, Gabriela Canto, Miguel Blanca, Jean-Louis Guéant P140 Detection of T cell responses to ticlopidine using peripheral blood mononuclear cells from HLA-A*33:03+ healthy donors Toru Usui, Arun Tailor, Lee Faulkner, John Farrell, Ana Alfirevic, B. Kevin Park, Dean J. Naisbitt P141 Epistasis approaches to identify novel genes potentially involved in NSAIDs hypersensitivity James Richard Perkins, Jose Antonio Cornejo García, Oswaldo Trelles, Inmaculada Doña, Esther Barrionuevo, María Salas, María Auxiliadora Guerrero, Miguel Blanca, Alex Upton P142 Genetic predisposition of cold medicine related SJS/TEN with severe ocular complications Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru Kinoshita P143 HLA-B*13:01 and dapsone induced hypersensitivity in Thai population Chonlaphat Chonlaphat Sukasem, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Kulprapat Pairayayutakul, Jettanong Klaewsongkram P144 HLA-B*15:02 alleles and lamotrigine-induced cutaneous adverse drug reactions in Thai Chonlaphat Sukasem, N. Koomdee, T. Jantararoungtong, S. Santon, A. Puangpetch, U. Intusoma, W. Tassaneeyakul, V. Theeramoke P145 HLA-B*38:01 and HLA-A*24:02 allele frequencies in Spanish patients with lamotrigine-induced SCARs Teresa Bellón, Elena Ramirez, Alberto Manuel Borobia, Hoi Tong, Jose Luis Castañer, Francisco José De Abajo P146 Overrepresentation of a class II HLA haplotype in severe hypersensitivity type I reactions to carboplatin Violeta Régnier Galvao, Rebecca Pavlos, Elizabeth Mckinnon, Kristina Williams, Alicia Beeghly-Fadiel, Alec Redwood, Elizabeth Phillips, Mariana Castells Poster walk 17: in vivo diagnosis + sIgE (P147–P154) P147 Absence of specific Ig-e against beta-lactams 9 months after an allergic reaction to amoxicillin-clavulanic acid Elisa Boni, Marina Russello, Marina Mauro P148 Drug provocation tests in suspected opioid allergy Kok Loong Ue, Krzysztof Rutkowski P149 Improvement to the specific IgE cut-off in the assess of β-lactamic allergy Victor Soriano Gomis, Jorge Frances Ferre, Angel Esteban Rodriguez, Vicente Cantó Reig, Javier Fernandez Sanchez P150 Initial false negative specific IgE to gelatin in a patient with gelatin-induced anaphylaxis Christine Breynaert, Erna Van Hoeyveld, Rik Schrijvers P151 Inmediate reactions to beta-lactam antibiotics: pattern of skin test response over the time Jose Julio Laguna Martinez, Rosario Gonzalez Mendiola, Javier Dionicio Elera, Cosmin Boteanu, Aranzazu Jimenez Blanco, Marta Del Pozo, Raquel Fuentes Irigoyen P152 New fluorescent dendrimeric antigens for the evaluation of dendritic cell maturation as a test to detect allergy reactions to amoxicillin Daniel Collado, Yolanda Vida, Francisco Najera, Ezequiel Perez-Inestrosa, Pablo Mesa-Antunez, Cristobalina Mayorga, María José Torres, Miguel Blanca P153 Positive skin test or positive specific IgE to penicillin does not predict penicillin allergy Line K. Tannert, Charlotte G. Mortz, Per Stahl Skov, Carsten Bindslev-Jensen P154 Significance of skin testing and in vitro-analysis of neuromuscular blocking agents in diagnosis of perioperative drug hypersensitivity: evaluation of a negative control population Wolfgang Pfützner, Hannah Dörnbach, Johanna Visse, Michele Rauber, Christian Möbs Poster walk 18: in vitro/ex vivo (P155–P158, P160–P164) P155 Diagnostic value of the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (IPTA) for β-lactam allergy Abdelbaset A. Elzagallaai, Lindsey Chow, Awatif M. Abuzgaia, Michael J. Rieder P156 Enzyme linked immunospot assay used in the diagnosis of severe cutaneous adverse reactions to antimicrobials Alec Redwood, Jason Trubiano, Rebecca Pavlos, Emily Woolnough, Kaija Stautins, Christina Cheng, Elizabeth Phillips P157 Evaluation of in vitro diagnostic methods for identifying the culprit drugs in drug hypersensitivity Kenichi Kato, Hiroaki Azukizawa, Takaaki Hanafusa, Ichiro Katayama P158 Ex-vivo expanded skin-infiltrating T cells from severe drug eruptions are reactive with causative drugs: a possible novel method for determination of causative drugs Toshiharu Fujiyama, Hideo Hashizume, Takatsune Umayahara, Taisuke Ito, Yoshiki Tokura P160 In vitro release of IL-2, IL-5 and IL-13 in diagnosis of patients with delayed-type nickel hypersensitivity Mira Silar, Mihaela Zidarn, Helena Rupnik, Peter Korosec P161 Single cell analysis of drug responsive T cells; identification of candidate drug reactive T cell receptors in abacavir and carbamazepine hypersensitivity Alec James Redwood, Kaija Strautins, Katie White, Abha Chopra, Katherine Konvinse, Shay Leary, Rebecca Pavlos, Simon Mallal, Elizabeth Phillips P162 Specificity and sensitivity of LTT in DRESS: analysis of agreement with the Spanish pharmacovigilance system probability algorithm Rosario Cabañas, Elena Ramirez, Ana María Fiandor, Teresa Bellón P163 The role of interleukin-22 in β-lactam hypersensitivity Andrew Sullivan, Paul Whitaker, Daniel Peckham, B. Kevin Park, Dean J. Naisbitt P164 Vancomycin-specific T cell responses and teicoplanin cross-reactivity Wei Yann Haw, Marta E. Polak, Carolann Mcguire, Michael R. Ardern-Jones Poster walk 19: BAT and biomarkers (P165–P173) P165 A combination of early biomarkers useful for the prediction of severe ADRs Yumi Aoyama, Tetsuo Shiohara P166 Basophil activation test in the diagnostic approach of reactions during general anaesthesia Ana Moreira, Susana Cadinha, Patrícia Barreira, Ana Castro Neves, Daniela Malheiro, Sara Correia, J. P. Moreira Da Silva P167 IL-10 can be related to successful desensitization Asli Gelincik, Semra Demir, Fatma Sen, Hamza Ugur Bozbey, Muge Olgac, Derya Unal, Raif Coskun, Bahauddin Colakoglu, Suna Buyuozturk, Esin Çatin-Aktas, Gunnur Deniz P168 Immediate reactions to proton pump inhibitors: value of basophil activation test Maria Salas, Jose Julio Laguna, Esther Barrionuevo, J. Dionicio, Tahia Fernandez, R. Gonzalez-Mendiola, I. Olazabal, Maria Dolores Ruiz, Miguel Blanca, Cristobalina Mayorga, Maria José Torres P169 Improvement of the elevated tryptase criterion to discriminate IgE from non-IgE mediated allergic reactions Gabriel Gastaminza, Alberto Lafuente, Carmen D’Amelio, Amalia Bernad, Olga Vega, Roselle Catherine Madamba, M. Jose Goikoetxea, Marta Ferrer, Jorge Núñez P170 Low expression of Tim-3 could serve as a biomarker for control and diagnose maculopapular exanthema induced by drugs Tahia Diana Fernández, Inmaculada Doña, Francisca Palomares, Rubén Fernández, Maria Salas, Esther Barrionuevo, Maria Isabel Sanchez, Miguel Blanca, Maria José Torres, Cristobalina Mayorga P171 Role of basophil activation test using two different activation markers for the diagnosis of allergy to fluoroquinolones Esther Barrionuevo, Tahía Fernandez, Arturo Ruiz, Adriana Ariza, Maria Salas, Inmaculada Doña, Ana Molina, Miguel Blanca, Maria Jose Torres, Cristobalina Mayorga P172 The importance of basophil activation test in anaphylaxis due to celecoxib Amalia Bernad Alonso, Carmen D’Amelio Garófalo, Olga Vega Matute, Marta Ferrer Puga, María José Goikoetxea Lapresa, Roselle Catherine Yu Madamba, Gabriel Gastaminza Lasarte P173 The role of basophil activation test in the diagnosis of immediate type drug hypersensitivity to betalactam antibiotics Antonia Thinnes, Hans F. Merk, Jens Malte Baron, Martin Leverkus, Galina Balakirski Poster walk 20: TCR recognition, cellular (P174–P183) P174 Characterisation of the effect of co-inhibitory signalling on the activation of drug-derived antigen-specific T-cells Andrew Gibson, Monday Ogese, Lee Faulkner, B. Kevin Park, Dean J. Naisbitt P175 Characterization of drug hapten-specific T cell responses in piperacillin hypersensitive patients Zaid Al-Attar, Fiazia Yaseen, Xiaoli Meng, Rozalind Jenkins, Paul Whitaker, Daniel Peckham, Lee Faulkner, John Farrel, Kevin Park, Dean Naisbitt P176 Characterization of the response of T-cells to telaprevir and its metabolite in normal volunteers Zaid Al-Attar, Khetam Alhilali, Yanni Xue, John Farrell, Lee Faulkner, Kevin Park, Dean Naisbitt P177 Characterization of the T cell receptor signatures of drug-responsive T cells Patricia Illing, Nicole Mifsud, Heidi Fettke, Jeffrey Lai, Rebecca Ho, Patrick Kwan, Anthony Purcell P178 Defining the signals between hepatocytes and immune cells in idiosyncratic drug-induced liver injury (DILI) Monday O. Ogese, Lee Faulkner, B. Kevin Park, Catherine Betts, Dean J. Naisbitt P179 Development of novel chemicals that do not bind to HLA-B*57:01 or activate CD8 + T-cells through modification of the 6-amino cyclopropyl group of abacavir Paul Thomson, John Farrell, Mohammad Alhaidari, Neill Berry, Paul M. O’Neill, B. Kevin Park, Dean J. Naisbitt P180 Generation and characterization of dapsone- and nitroso-dapsone-specific T-cell clones using lymphocytes from healthy volunteers Abdulaziz Alzahrani, Monday O. Ogese, John Farrell, Lee Faulkner, Andrew Gibson, Arun Tailor, B. Kevin Park, Dean J. Naisbitt P181 Identification of benzylpenicillin-hapten peptides responsible for naïve T-cell activation and immunization of allergic patients to penicillin Marie Eliane Azoury, Lucia Fili, Rami Bechara, Noémie Scornet, Cathy Nhim, Richard Weaver, Nancy Claude, Delphine Joseph, Bernard Maillere, Paola Parronchi, Marc Pallardy P182 Massive expansion of clonotypic and polycytotoxic CD8+ T cells in toxic epidermal necrolysis Axel Patrice Villani, Aurore Rozières, Benoît Bensaïd, Mathilde Tardieu, Floriane Albert, Virginie Mutez, Tugba Baysal, Marc Pallardy, Janet Maryanski, Jean-François Nicolas, Osami Kanagawa, Marc Vocanson P183 Pharmaco-immunological synapse of HLA-drug-TCR in SCAR Shuen-Iu Hung Poster walk 21: new in vitro methods, haptens, etc. (P184–P194) P184 Amoxicillin-clavulanate forms distinct multiple haptenic structures on human serum albumin in patients Xiaoli Meng, Arun Tailor, Caroline J. Harrison, Rosalind E. Jenkins, Paul Whitaker, Neil S. French, Dean J. Naisbitt, B. Kevin Park P185 Dendrimeric antigens for studying the influence of penicillin determinants orientation on IgE recognition Maria Isabel Montañez, Cristobalina Mayorga, Francisco Najera, Adriana Ariza, Tahia D. Fernandez, Maria Salas, Angela Martin-Serrano, Miguel Blanca, Ezequiel Perez-Inestrosa, Maria Jose Torres P186 Dendrimeric antigens on solid supports: designed materials for IgE quantification Yolanda Vida, Maria Isabel Montañez, Noemi Molina, Daniel Collado, Francisco Najera, Adriana Ariza, Maria Jose Torres, Cristobalina Mayorga, Ezequiel Perez-Inestrosa P187 Development of a screening assay for drug hypersensitivity using naïve T cells from donors with seven different HLA class I risk alleles Lee Faulkner, Sally Wood, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park P188 Different patterns of recognition of structures derived from amoxicillin by IgE antibodies from patients with immediate hypersensitivity reactions to betalactams Adriana Ariza, Cristobalina Mayorga, María Isabel Montañez, María Salas, Inmaculada Doña, Ángela Martín-Serrano, Ezequiel Pérez-Inestrosa, Dolores Pérez-Sala, Miguel Blanca, Antonio E. Guzmán, María José Torres P189 High-resolution typing of HLA polymorphism and T-cell receptor repertoire for severe adverse drug reactions based on the cost-effective next-generation sequencing approaches Tai-Ming Ko, Yuan-Tsong Chen, Jer-Yuarn Wu P190 Identification and fate of intracellular proteins haptenated by amoxicillin Francisco J. Sánchez-Gómez, Juan M. González-Morena, Yolanda Vida, Ezequiel Pérez-Inestrosa, Miguel Blanca, María J. Torres, Dolores Pérez-Sala P191 In vitro detection of terbinafine protein adducts Arun Tailor, Toru Usui, Yanni Xue, Xiaoli Meng, Dean J. Naisbitt, B. Kevin Park P192 MicroRNAs dysregulation in PBMCs from drug hypersensitivity patients during drug challenge in vitro Alejandra Monroy Arreola, Jesus Agustin Badillo Corona, Silvia Mendez Flores, Judith Dominguez Cherit, Dean J. Naisbitt, Noe Valentin Duran Figueroa, Jose Luis Castrejon Flores P193 NSAIDs-exacerbated cutaneous disease: high throughput gene expression profiling José Antonio Cornejo-García, James Perkins, Natalia Blanca-López, Diana Pérez-Alzate, Raquel Jurado-Escobar, Inmaculada Doña, Gador Bogas, María J. Torres, Gabriela Canto, Miguel Blanca P194 Utility of skin tests in non-immediate reactions to amoxicillin Luis Mario Tubella Marti, Fernando Pineda De La Losa, Francisca Arribas Poves, Jaime Tubella Lopez, Teodora Lopez Santiag