2,631 research outputs found
Supraspinatus detachment causes musculotendinous degeneration and a reduction in bone mineral density at the enthesis in a rat model of chronic rotator cuff degeneration
BACKGROUND: To evaluate biological strategies that enhance tendon-bone healing in humans, it is imperative that suitable animal models accurately reproduce the pathological changes observed in the clinical setting following a tear. The purpose of the present study was to investigate rotator cuff degeneration in a rat, as well as assess the development of osteopenia at the enthesis following tendon detachment. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon. Specimens were retrieved at 4 weeks (n = 6), 6 weeks (n = 6) and 9 weeks (n = 6) postoperatively for histological analysis and peripheral quantitative computer tomography. RESULTS: Three weeks following tendon detachment, there was a significant increase in the modified Movin score, characterized by a loss of muscle mass, fatty infiltration, an increase in musculotendinous cellularity, loss of normal collagen fibre structure/arrangement, rounded tenocyte nuclei and an increase in the number of vascular bundles. This was accompanied by a reduction in bone mineral density at the tendon insertion site. After 3 weeks however, these changes were less prominent. CONCLUSIONS: The rotator cuff tendon-muscle-bone unit in a rat model 3 weeks after detachment of supraspinatus represents a valid model for investigating rotator cuff degeneration
Modifying the Sum Over Topological Sectors and Constraints on Supergravity
The standard lore about the sum over topological sectors in quantum field
theory is that locality and cluster decomposition uniquely determine the sum
over such sectors, thus leading to the usual theta-vacua. We show that without
changing the local degrees of freedom, a theory can be modified such that the
sum over instantons should be restricted; e.g. one should include only
instanton numbers which are divisible by some integer p. This conclusion about
the configuration space of quantum field theory allows us to carefully
reconsider the quantization of parameters in supergravity. In particular, we
show that FI-terms and nontrivial Kahler forms are quantized. This analysis
also leads to a new derivation of recent results about linearized supergravity.Comment: 17 pages, minor change
Impact of obesity on global and regional systolic function in children: a CMR study
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An agency relationship under general conditions of uncertainty: A game theory application to the doctor-patient interaction
The supply of information, particularly of bad news, in an agency relationship is a sensitive issue. We employ a game theory approach to investigate conflicts in the particular case of the doctor–patient relationship when information affects the emotions of patients. The doctor does not know the type of agent and the patient does not know how much information he is given. Hence, the paper obtains results when there is conflict, rather than common interest in the objectives of the two parties. The perfect Bayesian equilibrium describes beliefs and strategies which guarantee adherence to the doctor’s recommendation. We show also that the patient may non-adhere to the recommendation not only when the doctor fails to identify the patient’s needs but also if he falsely believes that the doctor has not done so
Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability. It is unclear when the chromosome rearrangements are generated and whether individual replication problems or the resulting recombination intermediates delay the cell cycle. Here we have investigated checkpoint activation during HR-dependent replication restart using a site-specific replication fork-arrest system. Analysis during a single cell cycle shows that HR-dependent replication intermediates arise in S phase, shortly after replication arrest, and are resolved into acentric and dicentric chromosomes in G2. Despite this, cells progress into mitosis without delay. Neither the DNA damage nor the intra-S phase checkpoints are activated in the first cell cycle, demonstrating that these checkpoints are blind to replication and recombination intermediates as well as to rearranged chromosomes. The dicentrics form anaphase bridges that subsequently break, inducing checkpoint activation in the second cell cycle
Cartan-Weyl 3-algebras and the BLG Theory I: Classification of Cartan-Weyl 3-algebras
As Lie algebras of compact connected Lie groups, semisimple Lie algebras have
wide applications in the description of continuous symmetries of physical
systems. Mathematically, semisimple Lie algebra admits a Cartan-Weyl basis of
generators which consists of a Cartan subalgebra of mutually commuting
generators H_I and a number of step generators E^\alpha that are characterized
by a root space of non-degenerate one-forms \alpha. This simple decomposition
in terms of the root space allows for a complete classification of semisimple
Lie algebras. In this paper, we introduce the analogous concept of a
Cartan-Weyl Lie 3-algebra. We analyze their structure and obtain a complete
classification of them. Many known examples of metric Lie 3-algebras (e.g. the
Lorentzian 3-algebras) are special cases of the Cartan-Weyl 3-algebras. Due to
their elegant and simple structure, we speculate that Cartan-Weyl 3-algebras
may be useful for describing some kinds of generalized symmetries. As an
application, we consider their use in the Bagger-Lambert-Gustavsson (BLG)
theory.Comment: LaTeX. 34 pages.v2. deleted some distracting paragraphs in the
introduction to bring more out the main results of the paper. typos corrected
and references adde
Application of a Demineralized Cortical Bone Matrix and Bone Marrow-Derived Mesenchymal Stem Cells in a Model of Chronic Rotator Cuff Degeneration
BACKGROUND: The success of rotator cuff repair is primarily dependent on tendon-bone healing. Failure is common because weak scar tissue replaces the native enthesis, rendering it prone to reruptures. A demineralized bone matrix (DBM) consists of a network of collagen fibers that provide a sustained release of growth factors such as bone morphogenetic proteins. Previous studies have demonstrated that it can regenerate a fibrocartilaginous enthesis. HYPOTHESIS: The use of a DBM and mesenchymal stem cells (MSCs) at the healing enthesis will result in a higher bone mineral density at the tendon insertion and will enhance the regeneration of a morphologically superior enthesis when compared with an acellular human dermal matrix. STUDY DESIGN: Controlled laboratory study. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon. Three weeks later, tendon repair was carried out in animals randomized into 3 groups: group 1 received augmentation of the repair with a cortical allogenic DBM (n = 6); group 2 received augmentation with a nonmeshed, ultrathick, acellular human dermal matrix (n = 6); and group 3 underwent tendon-bone repair without a scaffold (n = 6). All animals received 1 × 10(6) MSCs delivered in fibrin glue to the repair site. Specimens were retrieved at 6 weeks postoperatively for histological analysis and the evaluation of bone mineral density. RESULTS: All groups demonstrated closure of the tendon-bone gap with a fibrocartilaginous enthesis. Although there were no significant differences in the enthesis maturation and modified Movin scores, repair augmented with a dermal matrix + MSCs exhibited a disorganized enthesis, abnormal collagen fiber arrangement, and greater cellularity compared with other MSC groups. Only repairs augmented with a DBM + MSCs reached a bone mineral density not significantly lower than nonoperated controls. CONCLUSION: A DBM enhanced with MSCs can augment rotator cuff healing at 6 weeks and restore bone mineral density at the enthesis to its preinjury levels. CLINICAL RELEVANCE: Biological augmentation of rotator cuff repair with a DBM and MSCs may reduce the incidence of retears, although further studies are required to determine its effectiveness
The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model.
BACKGROUND: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon. Three weeks later, tendon repair was carried out in animals randomized into 3 groups: group 1 animals were repaired with DBM (n = 6); group 2 received augmentation with the dermal scaffold (n = 6); and group 3 (controls) underwent nonaugmented tendon-bone repair (n = 6). Specimens were retrieved at 6 weeks postoperatively for histologic analysis and evaluation of bone mineral density. RESULTS: No failures of tendon-bone healing were noted throughout the study. All groups demonstrated closure of the tendon-bone gap with a fibrocartilaginous interface. Dermal collagen specimens exhibited a disorganized structure with significantly more abnormal collagen fiber arrangement and cellularity than in the DBM-based repairs. Nonaugmented repairs exhibited a significantly higher bone mineral density than in DBM and the dermal collagen specimens and were not significantly different from control limbs that were not operated on. CONCLUSION: The application of DBM to a rat model of chronic rotator cuff degeneration did not improve the composition of the healing enthesis compared with nonaugmented controls and a commercially available scaffold. However, perhaps the most important finding of this study was that the control group demonstrated a similar outcome to augmented repairs
The Classical Harmonic Vibrations of the Atomic Centers of Mass with Micro Amplitudes and Low Frequencies Monitored by the Entanglement between the Two Two-level Atoms in a Single mode Cavity
We study the entanglement dynamics of the two two-level atoms coupling with a
single-mode polarized cavity field after incorporating the atomic centers of
mass classical harmonic vibrations with micro amplitudes and low frequencies.
We propose a quantitative vibrant factor to modify the concurrence of the two
atoms states. When the vibrant frequencies are very low, we obtain that: (i)
the factor depends on the relative vibrant displacements and the initial phases
rather than the absolute amplitudes, and reduces the concurrence to three
orders of magnitude; (ii) the concurrence increases with the increase of the
initial phases; (iii) the frequency of the harmonic vibration can be obtained
by measuring the maximal value of the concurrence during a small time. These
results indicate that even the extremely weak classical harmonic vibrations can
be monitored by the entanglement of quantum states.Comment: 10 pages, 3 figure
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