The value of data and other non-traditional scholarly outputs in academic review, promotion, and tenure in Canada and the United States

Academics are regularly involved in a wide range of activities spanning research, teaching and service, and the breadth of necessary outputs for review, promotion, and tenure (RPT) in each category only continues to grow. How do faculty manage their academic careers in the face of such growing sets of demands? Although we know that discussions of research assessment across the academy are increasingly recognizing the need to value the creation of outputs beyond research published in peer-reviewed journals, it is not clear whether these discussions have made their way into formal assessment structures. By analyzing the extent to which non-traditional outputs, including data and software, are mentioned in the RPT documents of a representative set of 129 universities from the United States and Canada, this chapter offers empirical evidence from across many disciplines of which types of faculty work are recognized in the RPT processes, and which are not. We confirm that traditional outputs such as peer-reviewed journal articles, book chapters and monographs are mentioned almost universally, whereas data-related items such as datasets and databases are mentioned only by a fraction of institutions. We find that research-intensive institutions acknowledge more types of research outputs in general, whereas institutions that focus more on undergraduate and master’s degree programs tend to mention fewer forms of scholarship in their RPT guidelines. Within research-intensive institutions, units from the life sciences present a greater range of outputs in the guidelines offered to faculty, including the 15% that explicitly mention data-related outputs. In contrast, none of the academic units in mathematics and physical and social sciences in our sample recognize data-related outputs, and generally recognize fewer forms. Overall, we conclude that many current structures for faculty assessment do not explicitly recognize the increasing complexity and demands of faculty work

microRNAs in colon cancer : a roadmap for discovery

Cancer omics data are exponentially created and associated with clinical variables, and important findings can be extracted based on bioinformatics approaches which can then be experimentally validated. Many of these findings are related to a specific class of non-coding RNA molecules called microRNAs (miRNAs) (post-transcriptional regulators of mRNA expression). The related research field is quite heterogeneous and bioinformaticians, clinicians, statisticians and biologists, as well as data miners and engineers collaborate to cure stored data and on new impulses coming from the output of the latest Next Generation Sequencing technologies. Here we review the main research findings on miRNA of the first 10 years in colon cancer research with an emphasis on possible uses in clinical practice. This review intends to provide a road map in the jungle of publications of miRNA in colorectal cancer, focusing on data availability and new ways to generate biologically relevant information out of these huge amounts of data

CRK9 contributes to regulation of mitosis and cytokinesis in the procyclic form of Trypanosoma brucei

<p>Abstract</p> <p>Background</p> <p>The <it>Trypanosoma brucei </it>cell cycle is regulated by combinations of cyclin/CRKs (cdc2 related kinases). Recently, two additional cyclins (CYC10, CYC11) and six new CRK (CRK7-12) homologues were identified in the <it>T. brucei </it>genome database <abbrgrp><abbr bid="B1">1</abbr><abbr bid="B2">2</abbr></abbrgrp>.</p> <p>Results</p> <p>Individual RNAi knockdowns of these new proteins in the procyclic form of <it>T. brucei </it>showed no apparent phenotype except for the CRK9 depletion, which enriched the cells in G2/M phase. But a similar CRK9 knockdown in the bloodstream form caused no apparent phenotype. CRK9 lacks the typical PSTAIRE motif for cyclin binding and the phenylalanine "gatekeeper" but binds to cyclin B2 <it>in vitro </it>and localizes to the nucleus in both forms of <it>T. brucei</it>. CRK9-depleted procyclic-form generated no detectable anucleate cells, suggesting an inhibition of cytokinesis by CRK9 depletion as well. The knockdown enriched cells with one nucleus, one kinetoplast and two closely associated basal bodies with an average distance of 1.08 mm in between, which was shorter than the control value of 1.36 μm, and the cells became morphologically deformed and rounded with time.</p> <p>Conclusion</p> <p>CRK9 may play a role in mediating the segregation between the two kinetoplast/basal body pairs prior to cytokinetic initiation. Since such a segregation over a relatively significant distance is essential for cytokinetic initiation only in the procyclic but may not be in the bloodstream form, CRK9 could be specifically involved in regulating cytokinetic initiation in the procyclic form of <it>T. brucei</it>.</p