Corrigendum to “Recent changes in primary production and phytoplankton in the offshore region of southeastern Lake Michigan” [J. Great Lakes Res. 36 (Supplement 3) (2010) 20–29]

The authors regret that there is an error on the labels of two figures that were published in the paper referenced above. For Figs. 5b, c, and d and 7b and c the y-axes have the wrong labels. The following are the correct y-axis labels: Fig. 5b — the y-axis should range from 0 to 5, Fig. 5c — the y-axis should range from 0 to 2, Fig. 5d — the y-axis label should range from 0 to 3, Fig. 7b — the y-axis should range from 0 to 40, and for Fig. 7c — the y-axis should range from 0 to 50

Corrigendum to “Recent changes in primary production and phytoplankton in the offshore region of southeastern Lake Michigan” [J. Great Lakes Res. 36 (Supplement 3) (2010) 20–29]

The authors regret that there is an error on the labels of two figures that were published in the paper referenced above. For Figs. 5b, c, and d and 7b and c the y-axes have the wrong labels. The following are the correct y-axis labels: Fig. 5b — the y-axis should range from 0 to 5, Fig. 5c — the y-axis should range from 0 to 2, Fig. 5d — the y-axis label should range from 0 to 3, Fig. 7b — the y-axis should range from 0 to 40, and for Fig. 7c — the y-axis should range from 0 to 50

Can traditionally administered home remedies be recommended? An assessment of 287 herbal home remedies for cattle, sheep, goats, pigs and horses, collected in the Swiss Canton of Graubuenden

Introduction: In Switzerland, the administration of medicinal plants to livestock is almost completely confined to the use of home remedies. To save this traditional knowledge, which has been handed down through word of mouth, a project aims to collect this information from different regions of Switzerland. Grison home remedies have been evaluated to decide whether or not they can be recommended. Methods: 32 current or former Grison livestock keepers (average age 59 years) provided information on the home remedies they use or have used to maintain the health of their cattle, sheep, goats, pigs and horses and to treat them. The data collection was conducted by interview (28 on-site, 3 by phone, 1 in writing) with a standardised questionnaire about collecting medicinal plants, and preparing and administrating home remedies for farm animals. Only home remedies containing plants, lichens or products deriving from them were assessed by a practising veterinarian and a pharmacist. Results: Grison livestock keepers mentioned 407 home remedies. The assessment included 287 herbal home remedies with 346 different indications. The investigations resulted in classification into 3 categories: (1) 278 indications that can be recommended, provided, in some cases, changes were made to either their preparation or administration. (2) 17 indications that could not be assessed and (3) 51 indications where their use is not recommended at all. Overall, 122 different, mainly herbal ingredients were used in the home remedies assessed. The most frequently applied herbal drugs are shown in the table, including their legal status for use in food-producing animals and the results of the assessment. Discussion/Conclusion: To enable livestock keepers to gain access to traditional knowledge, experts need to make recommendations for appropriate preparation and application of home remedies, to provide advice on necessary precautions and information on the legal situation for use on farm animals

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

<p>Abstract</p> <p>Background</p> <p>We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4⁺CD25^HIFoxp3⁺regulatory T cells and expanded melanoma-specific CD8⁺T cells. The goal of this study was to assess the clinical efficacy of DAB/IL2 in an expanded cohort of stage IV melanoma patients.</p> <p>Methods</p> <p>In a single-center, phase II trial, DAB/IL2 (12 μg/kg; 4 daily doses; 21 day cycles) was administered to 60 unresectable stage IV melanoma patients and response rates were assessed using a combination of 2-[¹⁸F]-fluoro-2-deoxy-glucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging.</p> <p>Results</p> <p>After DAB/IL2 administration, 16.7% of the 60 patients had partial responses, 5% stable disease and 15% mixed responses. Importantly, 45.5% of the chemo/immuno-naïve sub-population (11/60 patients) experienced partial responses. One year survival was markedly higher in partial responders (80 ± 11.9%) relative to patients with progressive disease (23.7 ± 6.5%; <it>p </it>value < 0.001) and 40 ± 6.2% of the total DAB/IL2-treated population were alive at 1 year.</p> <p>Conclusions</p> <p>These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma.</p> <p>Trial registration</p> <p><a href="http://www.clinicaltrials.gov/ct2/show/NCT00299689">NCT00299689</a></p

Studies on Lake Erie's littoral algae; Host specificity and temporal periodicity of epiphytic diatoms

Substratum specificity and temporal periodicity of the attached diatom flora upon three aquatic vascular plants and an artificial substratum were examined in three Lake Erie marshes. No qualitative or quantitative specificity for substrata was observed. Variability of diatom assemblage structure within replicate samples of a particular substratum type was as great as, or greater than, variability between substrata. Diatom assemblages upon dowel rod displayed a mid to late summer density maximum. Variability of density maxima upon natural substrata was attributed to different growth rates of the host macrophytes. Diatom assemblages within each sampling site possessed a distinct temporal periodicity indicating that factors affecting diatom growth are heterogeneous in distribution throughout Lake Erie's littoral zone.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42923/1/10750_2004_Article_BF00013712.pd

Insights into APC/C: from cellular function to diseases and therapeutics

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics