Getting Serious about Thermonuclear Security: Need for New Tests, Augmented Capability and First use Doctrine & Posture

India has been an economic and military punching bag for China. This is India’s fault because it has done less than nothing to counter the pummeling except occasionally reacting (as on the Galwan) and then only defensively. It is time India, a nuclear laggard, adopted the strategy conventionally weak nuclear weapons states (Pakistan against India, North Korea against the US) have successfully wielded against stronger adversaries by threatening nuclear first use, and by substantiating such threat by laying down short fuse, forward nuclear tripwires. For an India that has historically quailed before China, making this new more assertive stance credible will require significant measures—resumption of thermonuclear testing, emplacing a differentiated two-tiered doctrine that replaces the impractical “massive retaliation” strategy with flexible and proportional response notions pivoting on nuclear first use but only versus China while retaining the “retaliation only” concept for everyone else, and alighting on a tiered posture supported by the buildup of ‘soft’ strategic infrastructure (a separate strategic budget, specialist nuclear officer cadres in the three services, and a mechanism for oversight of nuclear weapons designing activity). It is a doable strategy the Indian government should not shy away from.    &nbsp

India: labour heading west

The difficult working conditions of migrant labourers in the fisheries of the Sindhudurg district of Maharashtra raise both social and human-rights issues that need to be solved

Gender Differences in Coping with Chronic Illness.

Suicide is the ninth leading cause of death in the United States. Therefore, it is important to discover adaptive life-maintaining characteristics in high risk populations. Many patients with life-threatning illnesses have frequent suicidal thoughts. The difference in reasons for living between men and women with and without chronic illness was investigated. The suicide ideation was determined by ratings on a 48 item Reasons for Living questionnaire. Degree of chronocity of illness and illnes related issues were determined by a demographic questionnaire. Results showed that men commit suicide at a higher rate than women. Results of ANOVA\u27S indicated that individuals with chronic illness do not have fewer coping skills than individuals without chronic illness. Even though the present study did not indicate that chronic illness is one of the factors that precipitates suicide, research shows that in chronically ill patients depresion is a major risk factor for suicide. Thus it is necessary for researchers to discover additional reasons for living for these individuals to keep them from committing suicide

Getting Serious about Thermonuclear Security: Need for New Tests, Augmented Capability and First use Doctrine & Posture

India has been an economic and military punching bag for China. This is India’s fault because it has done less than nothing to counter the pummeling except occasionally reacting (as on the Galwan) and then only defensively. It is time India, a nuclear laggard, adopted the strategy conventionally weak nuclear weapons states (Pakistan against India, North Korea against the US) have successfully wielded against stronger adversaries by threatening nuclear first use, and by substantiating such threat by laying down short fuse, forward nuclear tripwires. For an India that has historically quailed before China, making this new more assertive stance credible will require significant measures—resumption of thermonuclear testing, emplacing a differentiated two-tiered doctrine that replaces the impractical “massive retaliation” strategy with flexible and proportional response notions pivoting on nuclear first use but only versus China while retaining the “retaliation only” concept for everyone else, and alighting on a tiered posture supported by the buildup of ‘soft’ strategic infrastructure (a separate strategic budget, specialist nuclear officer cadres in the three services, and a mechanism for oversight of nuclear weapons designing activity). It is a doable strategy the Indian government should not shy away from.    &nbsp

What Do We Want? Increased Hispanic Accrual on Cancer Clinical Trials! When Do We Want It? Now!

The Hispanic population is one of the fastest growing ethnicities in the United States. Cancer is leading cause of death in this demographic group and have up to 50% higher cancer mortality rates compared to the non-Hispanic white population in the United States. Hispanics face numerous cancer health disparities, including poverty, obesity, and access to health care and insurance. In our previous study, we noted a poor Hispanic accrual rate of 3.9% in all phase II and III cancer clinical trials published in the United States in 2012 and argued for better representation. To assess if a change was made seven years later, we reexamined the clinical trials published in the United States in 2019. We found 48 cancer clinical trials meeting our inclusion criteria. Only 23 (48%) reported information regarding minority accrual. Of these, 8 (17% of all) reported Hispanic accrual.  Altogether, of the 2559 patients reported in the 8 clinical trials, 104 (4.1%) were of Hispanic ethnicity, which nearly matches the 3.9% that we reported in 2014. In this manuscript, we highlight the disproportionately low rates of Hispanic accrual in cancer clinical trials and propose processes that will increase representation.&nbsp

Comparison of the spatial QRS-T angle derived from digital ECGs recorded using conventional electrode placement with that derived from Mason-Likar electrode position

Background: The spatial QRS-T angle is ideally derived from orthogonal leads. We compared the spatial QRS-T angle derived from orthogonal leads reconstructed from digital 12-lead ECGs and from digital Holter ECGs recorded with the Mason-Likar (M-L) electrode positions. Methods and results: Orthogonal leads were constructed by the inverse Dower method and used to calculate spatial QRS-T angle by (1) a vector method and (2) a net amplitude method, in 100 volunteers. Spatial QRS-T angles from standard and M-L ECGs differed significantly (57° ± 18° vs 48° ± 20° respectively using net amplitude method and 53° ± 28° vs 48° ± 23° respectively by vector method; p < 0.001). Difference in amplitudes in leads V4–V6 was also observed between Holter and standard ECGs, probably due to a difference in electrical potential at the central terminal. Conclusion: Mean spatial QRS-T angles derived from standard and M-L lead systems differed by 5°–9°. Though statistically significant, these differences may not be clinically significant

A Novel P300 speller with motor imagery embedded in a traditional oddball paradigm.

A Brain Computer Interface (BCI) provides a means, to control external devices, through the electrical activity of the brain, bypassing motor movement. Recent years have seen an increase in the application of P300 cognitive potential as a control and/or communication signal for the motor restoration in paralyzed patients, such as those in the later stages of ALS (Amyotrophic lateral sclerosis). Although many of these patients are in locked-in state i.e. where motor control is not possible, their cognition is known to remain intact. The P300 speller paradigm explored in this study relying on this cognition represented by the P300 peak potential in EEG (Electroencephalography) signals to restore communication. The conventional visual oddball paradigms used to elicit P300 potential may not be the optimum choice due to their need for precise eye-gazing, which may be challenge for many patients. This study introduces a novel paradigm with motor imagery as a secondary after-stimulus task in a traditional visual oddball paradigm for P300 Speller application. We observed increased P300 peak amplitude as well as the event-related desynchronization (ERD) associated with motor imagery in six healthy novice subjects. Acceptable detection accuracy was obtained in the five-trial averaged signals from 250 ms to 750 ms after the visual stimulation, whereby the early visual evoked potentials were excluded from classification. As an enhancement, efforts are being made to assess implementation by motor imagery embedded in an auditory oddball paradigm which would minimize the need for eye-gazing further. We can conclude from the results of this study that the proposed paradigm with motor imagery embedded in a traditional visual oddball paradigm might be a feasible option for communication restoration in paralyzed patients