Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates-1

Deduced from analysis of the human genome using NCBI map viewer Build 36.2 (September 2006). Genes are represented by boxes with gene names appearing above and gene subfamilies indicated by numbers inside. Letters on the far left indicate paralogon designation, while chromosomal locations are indicated on the far right. Numbers between genes are approximate intergenic distances in Kb. Background shading indicates paralogous genes. Blue and red dots indicate sites of inversions. Note that and genes appear only at the locus and and appear only at the locus. and genes are linked with and genes at more than one locus, suggesting that these genes were acquired by the cluster during or before the two rounds of vertebrate genome duplication. Also note that a and a gene are associated with on chromosome 4. A gene is located on the long arm of chromosome2, however at a distance to , suggesting that it is not an original component of the paralogon.<p><b>Copyright information:</b></p><p>Taken from "Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates"</p><p>http://www.biomedcentral.com/1471-2148/8/171</p><p>BMC Evolutionary Biology 2008;8():171-171.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2446394.</p><p></p

Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates-0

Ologous groups while light grey boxes indicate gene linkage. Bootstrap values below 70 have been removed. Only two Lbx proteins are included as the third sequence (found on scaffold 8483) is incomplete. Note that the Lbx sequences separate into two clear groups, Lbx1 and Lbx2, which are supported by bootstrap values of 79 and 83 (boxed), respectively. The chicken protein previously denoted as Lbx3 [18], the zebrafish protein previously denoted as Lbx1 [14] and one of the fugu, , stickleback and medaka sequences group with mammalian Lbx2 sequences. The two novel zebrafish Lbx sequences and the remaining teleost sequences group with mammalian, chicken and frog Lbx1. The tree shows significantly longer branch lengths for the Lbx2 proteins indicating that these sequences may be evolving at a quicker rate than the Lbx1 proteins. For common names of species see additional file .<p><b>Copyright information:</b></p><p>Taken from "Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates"</p><p>http://www.biomedcentral.com/1471-2148/8/171</p><p>BMC Evolutionary Biology 2008;8():171-171.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2446394.</p><p></p