MBL concentrations and PT IgG concentrations after the first booster vaccine in 355 adolescents.

<p>Mannose-binding lectin (MBL) concentrations (ng/ml) and IgG antibody concentrations (IU/ml) against pertussis toxin after the first booster vaccine in 355 adolescent subjects. No correlation between MBL and IgG concentrations were observed. Solid line indicates the nonlinear regression curve.</p

Geometric mean concentrations (GMC) of IgG antibodies against pertussis toxin, filamentous hemagglutinin and pertactin in 213 infant subjects with MBL wild type (A/A), heterozygotes variant type A/O (A/B, A/C, A/D) and homozygote variant type O/O (B/B, D/D, C/B) at age of 2,5 months, 13 months and 2 years.

<p>Abbreviations: GMC, geometric mean concentration; CI, confidence interval; *Kruskal-Wallis test for comparison of antibody concentrations between genotypes A/A, A/O and O/O. P-value <0.05 is considered as statistically significant.</p

Antibody geometric mean concentrations (GMC) after booster doses (pre and post) of acellular pertussis vaccine compained with tetanus and diphtheria toxoidsin 355 adolescent subjects with MBL wild type (A/A), heterozygotes variant type A/O (A/B, A/C, A/D) and homozygote variant type O/O (B/B, B/D, D/D, C/D, C/C).

<p>Abbreviations: GMC, geometric mean concentration; CI, confidence interval; *Kruskal-Wallis test for comparison of antibody concentrations between genotypes A/A, A/O and O/O. P-value <0.05 is considered as statistically significant.</p

<i>MBL2</i> genotypes; A/A, A/O and O/O, with the corresponding MBL concentrations in 355 adolescents (p<0.0001).

<p>A/A refers to wild type, A/O heterozygote variants and O/O homozygote variants, and O refers to exon1 variant alleles B, C or D. Statistical significance was calculated with Kruskal-Wallis test. The number of subjects in each group is shown. Data is represented with first and third quartile and median line. The ends of the whiskers represent maximum and minimum values of the data.</p

TLR2 genotype and bacterial colonization rate in 412 subjects.

<p>TLR2 genotype and bacterial colonization rate in 412 subjects.</p

MBL genotypes and bacterial colonization rate (%) in 412 subjects.

<p><i>P*</i> = A/O and O/O combined together when calculating the <i>P</i>-value.</p

TLR4 genotype and bacterial colonization rate in 412 subjects.

<p>TLR4 genotype and bacterial colonization rate in 412 subjects.</p

Impulse oscillometry presented as Z-scores in relation to <i>IL-10</i> rs1800871/rs1800872 polymorphisms in 99 children under the age of seven after hospitalisation for bronchiolitis at less than six months of age.

<p>Zrs = Total Impedance; Rrs = Resistance; Xrs = Reactance; Fres = Resonant Frequency; dRrs/df = Frequency Dependency of Resistance</p><p>^<b>a</b>adjusted for age, maternal smoking during pregnancy, RSV and rhinovirus aetiology of bronchiolitis and BMI Z-score</p><p>*allele carriers vs. non-carriers</p><p>Impulse oscillometry presented as Z-scores in relation to <i>IL-10</i> rs1800871/rs1800872 polymorphisms in 99 children under the age of seven after hospitalisation for bronchiolitis at less than six months of age.</p

Impulse oscillometry presented as Z-scores in relation to <i>IL-10</i> rs1800896 polymorphism in 99 children under the age of seven after hospitalisation for bronchiolitis at less than six months of age.

<p>Zrs = Total Impedance; Rrs = Resistance; Xrs = Reactance; Fres = Resonant Frequency; dRrs/df = Frequency Dependency of Resistance</p><p>^<b>a</b>adjusted for age, maternal smoking during pregnancy, RSV and rhinovirus aetiology of bronchiolitis and BMI Z-score</p><p>*allele carriers vs. non-carriers</p><p>Impulse oscillometry presented as Z-scores in relation to <i>IL-10</i> rs1800896 polymorphism in 99 children under the age of seven after hospitalisation for bronchiolitis at less than six months of age.</p

Combined <i>IL-10</i> rs1800896, rs1800871 and rs1800872 genotypes and haplotype frequencies of 99 children hospitalised for bronchiolitis in infancy.

<p>*<i>GTA/ACC or ACC/GTA not present as estimated from the study population frequencies</i>.</p><p>Combined <i>IL-10</i> rs1800896, rs1800871 and rs1800872 genotypes and haplotype frequencies of 99 children hospitalised for bronchiolitis in infancy.</p