Space Shuttle 2 advanced space transportation system, volume 2

To determine the best configuration from all candidate configurations, it was necessary first to calculate minimum system weights and performance. To optimize the design, it is necessary to vary configuration-specific variables such as total system weight, thrust-to-weight ratios, burn durations, total thrust available, and mass fraction for the system. Optimizing each of these variables at the same time is technically unfeasible and not necessarily mathematically possible. However, discrete sets of data can be generated which will eliminate many candidate configurations. From the most promising remaining designs, a final configuration can be selected. Included are the three most important designs considered: one which closely approximates the design criteria set forth in a Marshall Space Flight Center study of the Shuttle 2; the configuration used in the initial proposal; and the final configuration. A listing by cell of the formulas used to generate the aforementioned data is included for reference

Space Shuttle 2 Advanced Space Transportation System. Volume 1: Executive Summary

An investigation into the feasibility of establishing a second generation space transportation system is summarized. Incorporating successful systems from the Space Shuttle and technological advances made since its conception, the second generation shuttle was designed to be a lower-cost, reliable system which would guarantee access to space well into the next century. A fully reusable, all-liquid propellant booster/orbiter combination using parallel burn was selected as the base configuration. Vehicle characteristics were determined from NASA ground rules and optimization evaluations. The launch profile was constructed from particulars of the vehicle design and known orbital requirements. A stability and control analysis was performed for the landing phase of the orbiter's flight. Finally, a preliminary safety analysis was performed to indicate possible failure modes and consequences

Consumer Purchases of Biotech Sweet Corn: Results from a Market Experiment

In the increasingly consumer-driven food system, consumer preferences toward agricultural biotechnology have the potential to influence decisions about development and adoption of biotech crop varieties. Current knowledge about consumer attitudes toward biotech foods is largely based on a number of consumer surveys and a growing body of experimental auctions. This paper reports results of a market experiment designed to isolate the effect of the use of biotechnology on consumer choices between two otherwise identical products. Two related varieties of fresh-market sweet corn were grown, labeled, and sold side-by-side in nine participating grocery stores in the Philadelphia area. Sales data indicate a market share of biotech corn of about 45 percent, with store-specific shares varying between 10 and 80 percent. Over 700 surveys were collected in stores. Surprisingly, only 65 percent of respondents noticed that there were two types of corn for sale despite the labeling and merchandising, and 87 percent of the sample spent one minute or less choosing their corn. About half of the respondents had heard of biotechnology before, and 16 percent volunteered the biotechnology trait as an influence on their purchase decision. Approximately 40 percent of the sample purchased some of the biotech variety, with several respondents purchasing some of each.Institutional and Behavioral Economics,

Development of a new generation solid rocket motor ignition computer code

This report presents the results of experimental and numerical investigations of the flow field in the head-end star grain slots of the Space Shuttle Solid Rocket Motor. This work provided the basis for the development of an improved solid rocket motor ignition transient code which is also described in this report. The correlation between the experimental and numerical results is excellent and provides a firm basis for the development of a fully three-dimensional solid rocket motor ignition transient computer code

COVID-19 Health Preference Research: 4 Lessons Learned

Like the rest of the world, the pandemic has reshaped the lives and livelihoods of scientists in the health economics and outcomes research community. Many investigators in health preference research reacted by conducting empirical studies to better understand the value of health and health-related alternatives affected by COVID-19. The group identified 18 health preference studies currently under review or ongoing. On 17 June 2020, the first COVID-19 health preference research roundtable was held as an open meeting of the minds, allowing a healthy exchange of ideas between these study teams and other attendees interested in the area. From that discussion, this summary characterizes the state of science for the broader scientific community and for regulators and other decision makers looking for preference evidence regarding COVID-19

Strategies for assessing the implications of malformed frogs for environmental health.

The recent increase in the incidence of deformities among natural frog populations has raised concern about the state of the environment and the possible impact of unidentified causative agents on the health of wildlife and human populations. An open workshop on Strategies for Assessing the Implications of Malformed Frogs for Environmental Health was convened on 4-5 December 1997 at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina. The purpose of the workshop was to share information among a multidisciplinary group with scientific interest and responsibility for human and environmental health at the federal and state level. Discussions highlighted possible causes and recent findings directly related to frog deformities and provided insight into problems and strategies applicable to continuing investigation in several areas. Possible causes of the deformities were evaluated in terms of diagnostics performed on field amphibians, biologic mechanisms that can lead to the types of malformations observed, and parallel laboratory and field studies. Hydrogeochemistry must be more integrated into environmental toxicology because of the pivotal role of the aquatic environment and the importance of fates and transport relative to any potential exposure. There is no indication of whether there may be a human health factor associated with the deformities. However, the possibility that causal agents may be waterborne indicates a need to identify the relevant factors and establish the relationship between environmental and human health in terms of hazard assessment

Climate change promotes parasitism in a coral symbiosis.

Coastal oceans are increasingly eutrophic, warm and acidic through the addition of anthropogenic nitrogen and carbon, respectively. Among the most sensitive taxa to these changes are scleractinian corals, which engineer the most biodiverse ecosystems on Earth. Corals' sensitivity is a consequence of their evolutionary investment in symbiosis with the dinoflagellate alga, Symbiodinium. Together, the coral holobiont has dominated oligotrophic tropical marine habitats. However, warming destabilizes this association and reduces coral fitness. It has been theorized that, when reefs become warm and eutrophic, mutualistic Symbiodinium sequester more resources for their own growth, thus parasitizing their hosts of nutrition. Here, we tested the hypothesis that sub-bleaching temperature and excess nitrogen promotes symbiont parasitism by measuring respiration (costs) and the assimilation and translocation of both carbon (energy) and nitrogen (growth; both benefits) within Orbicella faveolata hosting one of two Symbiodinium phylotypes using a dual stable isotope tracer incubation at ambient (26 °C) and sub-bleaching (31 °C) temperatures under elevated nitrate. Warming to 31 °C reduced holobiont net primary productivity (NPP) by 60% due to increased respiration which decreased host %carbon by 15% with no apparent cost to the symbiont. Concurrently, Symbiodinium carbon and nitrogen assimilation increased by 14 and 32%, respectively while increasing their mitotic index by 15%, whereas hosts did not gain a proportional increase in translocated photosynthates. We conclude that the disparity in benefits and costs to both partners is evidence of symbiont parasitism in the coral symbiosis and has major implications for the resilience of coral reefs under threat of global change

Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting Vitamin A₁ into A₂

Some vertebrate species have evolved means of extending their visual sensitivity beyond the range of human vision. One mechanism of enhancing sensitivity to long-wavelength light is to replace the 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal. Despite over a century of research on this topic, the enzymatic basis of this perceptual switch remains unknown. Here, we show that a cytochrome P450 family member, Cyp27c1, mediates this switch by converting vitamin A(1) (the precursor of 11-cis retinal) into vitamin A(2) (the precursor of 11-cis 3,4-didehydroretinal). Knockout of cyp27c1 in zebrafish abrogates production of vitamin A(2), eliminating the animal's ability to red-shift its photoreceptor spectral sensitivity, and reducing its ability to see and respond to near-infrared light. Thus, the expression of a single enzyme mediates dynamic spectral tuning of the entire visual system by controlling the balance of vitamin A(1) and A(2) in the eye

Beeldcultuur, een drieluik.I: Deconstructie van het fenomeen culturele studies

An important process in glass manufacture is the forming of the product. The forming process takes place at high rate, involves extreme temperatures and is characterised by large deformations. The process can be modelled as a coupled thermodynamical/mechanical problem including the interaction between glass, air and equipment. In this paper a general mathematical model for glass forming is derived, which is specified for different forming processes, in particular pressing and blowing. The model should be able to correctly represent the flow of the glass and the energy exchange during the process. Various modelling aspects are discussed for each process, while several key issues, such as the motion of the plunger and the evolution of the glass-air interfaces, are examined thoroughly. Finally, some examples of process simulations for existing simulation tools are provided

Marketing (as) Rhetoric: paradigms, provocations, and perspectives

In this collection of short, invited essays on the topic of marketing (as) rhetoric we deal with a variety of issues that demonstrate the centrality of rhetoric and rhetorical considerations to the pursuit of marketing scholarship, research and practice. Stephen Brown examines the enduring rhetorical power of the 4Ps; Chris Hackley argues for the critical power of rhetorical orientations in marketing scholarship but cautions us on the need to work harder in conceptually connecting rhetorical theory and modern marketing frameworks; Shelby Hunt explains how rhetorical processes are incorporated in his inductive realist model of theory generation, using one of his most successful publications as an illustration; Charles Marsh demonstrates what Isocrates’ broad rhetorical project has to teach us about the importance of reputation cultivation in modern marketing; Nicholas O’Shaughnessy uses an analysis of Trump’s discourse to argue that political marketing as it is currently conceived is ill-equipped to engage effectively with the rhetorical force of Trump’s ‘unmarketing’; Barbara Phillips uses Vygotsky’s work on imagination to investigate the important of pleasure and play in advertising rhetoric; and finally, David Tonks, who in many ways started it all, reiterates the need for marketers to recognise the strength of the relationship between marketing and persuasion