341 research outputs found
Schutz der Ostsee durch Umstellung auf ökologisch kreislauforientierte Landwirtschaft: Praxisleitfäden und Software-Tools als Umstellungshilfe
The ecological status of the Baltic Sea is endangered. The high nutrient surplus from intensive agriculture is the main reason for the pollution. In a joint project with all countries around the Baltic Sea, the EU funded project BERAS Implementation (Baltic Ecological Recycling Agriculture and Society) supports the conversion to ecological recycling agriculture (ERA) to ensure a sustainable protection of the Baltic Sea. The project aims to stimulate exchange of knowledge and experiences across countries, to build a network of experts including stakeholders from science, advisory services, ministries, and the food sector and to enhance the demand for organic products. Practical guidelines and software-tools were developed to support farmers in the conversion process to ERA farming. These materials provide guidelines for sustainable production of crops and livestock, farm economics and marketing, and farm management tools for crop rotation planning and on-farm nutrient management
20 Jahre Modellbetrieb für Ökolandbau in Müncheberg. Teil 1: Entwicklung von Humus- und Nährstoffgehalten
Acht Felder der Versuchsstation des ZALF in Müncheberg in Nordostdeutschland wurden 1993 als Modellbetrieb mit einer Leguminosen-betonten Fruchtfolge auf Ökologischen Landbau umgestellt. Je Feld wurde 1995 ein Monitoringversuch mit je 5 Ernte- bzw. Beprobungsparzellen angelegt. Neben Ernteerhebungen erfolgte eine jährliche Krumenbeprobung zur Untersuchung der Entwicklung der Gehalte an organischem Kohlenstoff (Corg) und Stickstoff (Norg) sowie der P- und K-Verfügbarkeit. Eine deutliche Zunahme der Corg-Gehalte zeigte sich nur auf den Flächen mit Texturklasse Sand. Dagegen stiegen die Norg-Gehalte auch auf den besseren Böden, allerdings in geringerem Maße, an. Die P-Verfügbarkeit pegelte sich nach einem anfänglichen Rückgang auf Werte der Versorgungsstufe C ein. Die Kalium-Verfügbarkeit ist weiter rückläufig, so dass sich zur Vermeidung von Ertragseinbußen ein bessere Rezyklierung bzw. Düngung zukünftig als notwendig erweisen wird
Ecological and agronomic evaluation of crop rotations in organic farming systems
The integration of nature conservation measures in organic farming requires special know-ledge about potential goal conflicts between ecological and agronomic requirements. The aim of this paper is to introduce a generation and evaluation tool for crop rotations that allows an assessment of the complex interdependencies of different biotic and abiotic parameters. The interdisciplinary ‘Nature Conserva-tion Farm Brodowin’ project provides the experimen-tal basis for developing practical solutions and compromises in this context. Two generated six-course crop rotations are presented as examples of this approach. The results show the sensitivity of the evaluation tool and its usability for improving crop rotations with regard to nature conservatio
20 Jahre Modellbetrieb für Ökolandbau in Müncheberg. Teil 2: Wie ertragslabil sind Körnerleguminosen im Vergleich zu Getreide und Mais?
Auf dem Modellbetrieb für Ökolandbau in Müncheberg wurden von 1993 bis 2013 Feldversuche zur Ermittlung der Ertragsstabilität von zwei Körnerleguminosen (Schmalblättrige Lupine und Futtererbse), Wintergetreide (Roggen und Weizen), Hafer und Silomais durchgeführt. Zwei orthogonale Datensätze wurden genutzt um die temporären Ertragsschwankungen der Einzelkulturen zu vergleichen. Beide Körnerleguminosen zeigten die geringste Ertragsstabilität von allen untersuchten Kulturen. Dies war sowohl für varianzbasierte als auch für regressionsbasierte Stabilitätsparameter der Fall. Gründe für die geringe Ertragsstabilität sind unzureichend bekannt. Es müssen Strategien für das Management entwickelt werden, um mit den großen Schwankungen umzugehen
Redhostimentum M. Johannis Steini[i], ad Johannis Mautneri Pannonii, Rosam Varniacam, seu Lyceum Rostochiense Anagrammaticum, sibi dono transmissum: Hoc est, Dyōdekas anagrammatōn Ex nomine Authoris Rosae Varniacae deductorum; Eunoias kai Filias ergo conscripta & ab Enantipaschonti transmissa
Triga Charitum, Quam, Pro Statua Memoriali Natalis nostri, a ... Dn. Joanne Mautnero Pannonio, Amico nostro Apollineo, ac prae Gratiis ispsis gratioso; In Redhostimentum declarati nostri favoris; Ac Contrapignus oblatae nostrae Amicitiae; Nec non Interusurium acceptorum Carminum Erecta: In animi grati Testificationem; Accepti beneficii Remunerationem; Ac amicitiae inceptae Confirmationem; Amoris favoris, ac benivolentiae habenis moderatam tanquam ex debito remitto
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy
Perinatal mortality is a heavy burden for both affected parents and physicians. However, the underlying genetic causes have not been sufficiently investigated and most cases remain without diagnosis. This impedes appropriate counseling or therapy. We describe four affected children of two unrelated families with cardiomyopathy, hydrops fetalis, or cystic hygroma that all deceased perinatally. In the four patients, we found the following homozygous loss of function (LoF) variants in SLC30A5 NM_022902.4:c.832_836del p.(Ile278Phefs*33) and NM_022902.4:c.1981_1982del p.(His661Tyrfs*10). Knockout of SLC30A5 has previously been shown a cardiac phenotype in mouse models and no homozygous LoF variants in SLC30A5 are currently described in gnomAD. Taken together, we present SLC30A5 as a new gene for a severe and perinatally lethal form of cardiomyopathy
Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence
Specific mammalian genes functionally and dynamically associate together within the nucleus. Yet, how an array of many genes along the chromosome sequence can be spatially organized and folded together is unknown. We investigated the 3D structure of a well-annotated, highly conserved 4.3-Mb region on mouse chromosome 14 that contains four clusters of genes separated by gene “deserts.” In nuclei, this region forms multiple, nonrandom “higher order” structures. These structures are based on the gene distribution pattern in primary sequence and are marked by preferential associations among multiple gene clusters. Associating gene clusters represent expressed chromatin, but their aggregation is not simply dependent on ongoing transcription. In chromosomes with aggregated gene clusters, gene deserts preferentially align with the nuclear periphery, providing evidence for chromosomal region architecture by specific associations with functional nuclear domains. Together, these data suggest dynamic, probabilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the diverse activities of multiple genes and their conserved primary sequence organization
Supremus Honor, Quem Viro Dum Viveret, Spectatissimo, Jacobo Volkmar, Pharmacopoeo, Privilegio Sacr. Reg. Majest. Confirmato, Cum Die 18. Februar. A.C. 1717. Placide Obdormivisset, Ejusque Corpus Die 1. Martii in Templo Neo-Rosgartensi, Dormitorio Esset Illatum, In Perennem Et Post Fata Memoriam, Exhibituri Epicedia Quædam Posuerunt, Regiæ Prussorum Acadamiæ Pro-Rector Et Professores Intus Nominati
Trial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3
Evolving treatments, disease phenotypes, and biology, together with a changing drug development environment, have created the need to revise castration-resistant prostate cancer (CRPC) clinical trial recommendations to succeed those from prior Prostate Cancer Clinical Trials Working Groups
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