EFFECT OF POSITIVE RUMINATION-BASED SPORTS PRESCRIPTION ON THE MENTAL HEALTH OF TEENAGERS

Background: Under the pressure of study, relationship, socializing, employment and other aspects, there is an increasing number of teenagers with psychological problems such as pessimism, anxiety, and depression, seriously affecting their physical and mental health and comprehensive development. Therefore, it is of vital importance to attach great importance and actively seek intervention methods to effectively improve their mental health. The aim was to investigate the intervention effect of positive rumination-based sports prescription on the mental health of teenagers. Subjects and methods: 497 teenagers living in four communities randomly selected in Guangxi, China community from February 2021 to August 2021 were included in this study using convenience sampling method. Firstly, Beck Depression Inventory was adopted for measurement, and 61 volunteers were randomly selected from a population of depressive symptoms to participate in intervention. There were 29 people the Experimental group, 32 in the control group. The intervention using positive ruminationbased sports prescription was performed on the Experimental group. Results: After intervention, the depression score of the control group and the Experimental group was lower than that before intervention (P<0.001). After intervention, the anxiety score of Experimental group was significantly lower than that of the control group (P<0.001). There was no significant difference in the scores regarding optimism, hope, self-efficacy, resiliency and psychological capital (P>0.05), and the scores of the Experimental group regarding optimism, hope, self-efficacy, resiliency and psychological capital were increased after the intervention, significantly higher than before intervention (P<0.001), and there was no significant difference in the score of resiliency before and after intervention (P>0.05). Conclusion: Positive rumination group counseling and the intervention of health Qigong exercise can effectively reduce anxiety levels of teenagers, improve the levels of optimism, hope, self-efficacy, resiliency and psychological capital, help cultivate teenagers’ positive psychology and alleviate negative psychology

PEER EDUCATION INTERVENTION ON ADOLESCENTS’ ANXIETY, DEPRESSION, AND SLEEP DISORDER DURING THE COVID-19 PANDEMIC

Background: Adolescents’ anxiety and depression during the coronavirus disease 2019 (COVID-19) pandemic outbreak cannot be ignored. In public health crisis events, adolescents are prone to negative psychological problems, such as anxiety and depression. Hence, this research focuses on the use of reasonable and efficient methods to intervene in adolescents’ psychological problems during the COVID-19 pandemic. Subjects and methods: From February to April 2020, we conducted an anonymous online survey on a total of 1,200 adolescents in the provinces of Hunan and Guangxi in China. Moreover, we randomly divided a total of 150 middle school students with anxiety scores greater than 50 and volunteered to participate in the intervention experiment into control and intervention groups, with 75 members in each group. On the basis of the proposed routine treatment, we conducted 8 weeks of model 328-based peer education intervention in the intervention group. Results: After the intervention, the self-rating anxiety scale scores (SAS) of the intervention group are better than those of the control group (P<0.001). Moreover, the self-rating depression scale (SDS) scores of both groups are reduced, but the effect is more significant on the intervention group (P<0.001) than on the control group. Finally, the total Pittsburgh sleep quality index (PSQI) scores of both groups are reduced, but the effect is more significant on the intervention group than on the control group (P=0.001 and <0.001, respectively). Conclusions: Model 328-based peer education intervention can significantly reduce the level of anxiety and depression in adolescents and improve their sleep quality

INTERVENTION EFFECT OF SENSORY INTEGRATION TRAINING ON THE BEHAVIORS AND QUALITY OF LIFE OF CHILDREN WITH AUTISM

Background: Autism is a widespread developmental disorder that occurs mostly among children. Children with autism are prone to problematic behaviors due to their deficiencies in language communication and social development. Thus, children with a high degree of autism suffer lower life satisfaction. Moreover, sensory integration dysfunction is closely related to autism. Therefore, the effect of Sensory Integration Training (SIT) on the behaviors and quality of life of children with autism was explored in this study. Subjects and methods: From September 2017 to December 2018, 108 patients from Fuzhou Fourth Hospital and Xiangtan Fifth Hospital were included in the intervention group (group A) and the control group (group B), with 54 members in each group. The 54 members in group B, with an average age of 5.18±2.94, received routine treatment. In addition to the same routine treatment, the members in group B also received sensory integration training and physical exercise intervention, which lasted for three months. The Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC) were used before and after the intervention experiment to evaluate the curative effect. Results: After the treatment, statistically significant differences were observed in the CARS and ABC scores (P<0.05); the total effective rate was 86.11% in group A and 64.10% in group B. The difference in the CARS score was statistically significant (P<0.05), whereas the difference in the ABC score was also statistically significant (P<0.05). In general, the difference in CARS is statistically significant. Specifically, group A is better than group B, t=3.492, df=73, and bilateral P=0.001<0.01. Conclusions: SIT intervention had a certain effect on autism and is of great value for the future development of SIT courses or intervention programs for children with autism

Targeting Neuroglial Sodium Channels in Neuroinflammatory Diseases

The Hodgkin-Huxley model, at its 66th anniversary, remains a footing stone of neuroscience, which describes how the action potential (AP) is generated. As the core player of AP initiation, voltage-gated sodium channels (VGSCs) are always considered to be required for electrogenesis in excitable cells. Cells which are not traditionally been considered to be excitable, including glial cells, also express VGSCs in physiological as well as pathological conditions. The dysfunction of glial VGSCs is seemingly not related to abnormal excitation of neurons, but of importance in the astrogliosis and M1 polarization of microglia, which could induce refractory neuroinflammatory diseases, such as multiple sclerosis, stroke, epilepsy, and Alzheimer’s and Parkinson’s diseases. Therefore, in this chapter, we aim to describe the physiological and pathological roles of VGSCs contributing to the activity of glial cells and discuss whether VGSC subtypes could be used as a novel drug target, with an eye toward therapeutic implications for neuroinflammatory diseases

Perforating scleral vessels adjacent to myopic choroidal neovascularization achieved a poor outcome after intravitreal anti-VEGF therapy

BackgroundThis study aimed to summarize the features of perforating scleral vessels (PSVs) in patients with myopic choroidal neovascularization (CNV) (mCNV) using optical coherence tomography angiography (OCTA) and to identify the associations with the response after intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy.MethodsA consecutive series of naïve patients who had mCNV and received intravitreal anti-VEGF therapy with a follow-up duration of 12 months or more were enrolled. The prevalence, location, and branches of PSVs were analyzed. Projection-resolved OCTA (PR-OCTA) was used to analyze the neovascular signals between CNV and PSVs. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were measured. The proportion of CMT change relative to baseline was used to assess therapeutic response.ResultsA total of 44 eyes from 42 patients with mCNV were enrolled. PSVs were identified in 41 out of 44 eyes. Branches were identified in the PSVs of 24 eyes (57.14%), and 20 eyes did not have PSV branches (47.62%). In eight eyes (18.18%), PSVs were adjacent to mCNV, and in 36 eyes (81.82%), PSVs were not adjacent to mCNV. After anti-VEGF therapy for mCNV, BCVA increased (F = 6.119, p &lt; 0.001) and CMT decreased (F = 7.664, p &lt; 0.001). In the eyes where PSVs were adjacent to mCNV, BCVA improvements (F = 7.649, p = 0.009) were poor, and changes in CMT were small.ConclusionThe eyes with PSVs adjacent to mCNV showed poor therapeutic responses after intravitreal anti-VEGF therapy