Estandarización del proceso logístico en el despacho de producto para asegurar la cadena de frío en el transporte nacional de producto para Nissi S.A.S

El objetivo principal de este trabajo es encontrar las condiciones adecuadas en las cuales se debe transportar el medicamento comercializado por NISSI S.A.S., medicamento que exige un rango de temperatura determinado y además actualizar los instructivos de alistamiento y cargue de producto asegurando la cadena de frío hasta la entrega el cliente final, teniendo como finalidad garantizar la inocuidad de los productos y el cumplimiento de las regulaciones Colombianas que apliquen a la empresa por su actividad comercializadora de medicamento. La técnica utilizada para lograr el objetivo planteado se basó en hacer un seguimiento al comportamiento de los rangos de temperatura aportados por las gráficas obtenidas de la información generada por las pruebas realizadas y teniendo en cuenta las variables como: tiempo de congelación de las pilas (Horas), volumen de los contenedores isotérmicos (Litros), cantidad de pilas a usar (Unidades), Cantidad de producto a conservar (N° de viales), ciudades destino, materiales de empaque y rango de temperatura de conservación del producto (° Celsius) entre otros; con el estudio anterior se logró establecer una tabla que indica de acuerdo a la cantidad de producto a enviar cantidad de pilas se deben empacar para asegurar el rango de la cadena de frío. Para llevar a cabo este estudio fue necesario materiales y equipos tales como Datalogger, Contenedores Isotérmicos, Acumuladores de frio, tecnología que permitiera obtener los datos de temperatura en las pruebas realizadas y un software que nos permitiera obtener gráficas para aplicar estadística y matemáticas básica

Systematic review of thinking skills in the classroom (2000-2013)

ABSTRACT: The present study summarizes the description of sexual dimorphism found on metric characteristics in a contemporary sample of skeletons. The burial individual record had data on sex, age, cause of death and birthplace. The metric information corresponding to 44 skull variables, jaw and long bones (humerus, fémur and tibia) was recorded on each subject. The sample consisted of 70 mature individuals of known sex (20 women and 50 males) from a cemetery of the city of Medellín, Colombia. When the statistical comparison between sexes was performed by means of a one-way F test only six of the studied variables were not significant (p > 0.05) to determine sex. In accord with these results, hierarchical list of variables for sex determination aim is proposed. Moreover, it has been conducted a discriminant analysis in order to obtaining prediction equations for sex. Tibia variables yield the highest total percentage of correct classification. They achieved also a higher classification percentage in men that in women, as it is in the qualitative analysis.Since the second half of the twentieth century, there has been a growing interest in the use of learning methods to assess and encourage the development of thinking skills in the classroom instead of the vertical transmission of a specific content. This study takes 60 academic articles published between 2000 and 2013 which had thinking skills as the central topic and analyzes their level of evidence and grade of recommendation following the Scottish Intercollegiate Guidelines Network (SIGN). The main findings were: most studies are developed with empirical analytical approaches and quasi-experimental designs; there are a variety of stimulation programs and data collection instruments that hinder a systematic analysis of programs; there are very different samples and intervened population used; and, finally, most studies are located at average levels of evidence and grades of recommendation.RESUMEN: Desde la segunda mitad del siglo XX, hay un interés creciente por el uso de metodologías de aprendizaje que evalúen y estimulen el desarrollo de habilidades de pensamiento en el aula, en vez de la transmisión vertical de contenidos específicos. El presente estudio retoma 60 artículos académicos publicados entre 2000 y 2013 que tenían como tema central las habilidades de pensamiento, analizando su nivel de evidencia y grado de recomendación según los lineamientos del Scottish Intercollegiate Guidelines Network (SIGN). Como hallazgos principales se encontró que la mayoría de estudios siguen enfoques empírico-analíticos y diseños cuasi experimentales. Hay una gran variedad de programas de estimulación y de instrumentos de recolección de información que dificultan un análisis sistemático de los programas. Son muy diversas las muestras utilizadas y la población intervenida y, finalmente, la mayoría de estudios se ubican en niveles moderados de evidencia y grados de recomendación

Structure and physical properties of the LaBiFe2O6 Perovskite produced by the Modified Pechini Method

ABSTRACT: In this paper the synthesis of the LaBiFe2O6 material by the modified Pechini method is reported. Structural, morphologic, magnetic and optic experimental studies were performed. Rietveld refinement of x-ray diffraction patterns revealed that LaBiFe2O6 crystallizes in an orthorhombic perovskite structure (space group Pnma, # 62). Scanning electron microscopy images showed the nanometric feature of grains. X-ray dispersive spectroscopy permitted to infer the obtaining of the LaBiFe2O6 expected stoichiometry. Results of magnetic susceptibility as a function of temperature and field magnetization evidenced mixed ferromagnetism and superparamagnetism behavior at T=300 K. Mössbauer spectroscopy supported the superparamagnetic and ferromagnetic responses as a result of the nanogranular morphology and anisotropy effects. Spectrum of diffuse reflectance suggest that this material behaves as a semiconductor with energy gap Eg=2.13 eV

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Measurement of B-c(2S)(+) and B-c*(2S)(+) cross section ratios in proton-proton collisions at root s=13 TeV

Peer reviewe

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements

This paper presents new sets of parameters (“tunes”) for the underlying-event model of the HERWIG7 event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in HERWIG7, and are obtained from a fit to minimum-bias data collected by the CMS experiment at s=0.9, 7, and 13Te. The tunes are based on the NNPDF 3.1 next-to-next-to-leading-order parton distribution function (PDF) set for the parton shower, and either a leading-order or next-to-next-to-leading-order PDF set for the simulation of MPI and the beam remnants. Predictions utilizing the tunes are produced for event shape observables in electron-positron collisions, and for minimum-bias, inclusive jet, top quark pair, and Z and W boson events in proton-proton collisions, and are compared with data. Each of the new tunes describes the data at a reasonable level, and the tunes using a leading-order PDF for the simulation of MPI provide the best description of the dat

Reconstruction of signal amplitudes in the CMS electromagnetic calorimeter in the presence of overlapping proton-proton interactions

A template fitting technique for reconstructing the amplitude of signals produced by the lead tungstate crystals of the CMS electromagnetic calorimeter is described. This novel approach is designed to suppress the contribution to the signal of the increased number of out-of-time interactions per beam crossing following the reduction of the accelerator bunch spacing from 50 to 25 ns at the start of Run 2 of the LHC. Execution of the algorithm is sufficiently fast for it to be employed in the CMS high-level trigger. It is also used in the offline event reconstruction. Results obtained from simulations and from Run 2 collision data (2015-2018) demonstrate a substantial improvement in the energy resolution of the calorimeter over a range of energies extending from a few GeV to several tens of GeV.Peer reviewe

Observation of the Production of Three Massive Gauge Bosons at root s=13 TeV

The first observation is reported of the combined production of three massive gauge bosons (VVV with V = W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis is based on a data sample recorded by the CMS experiment at the CERN LHC corresponding to an integrated luminosity of 137 fb(-1). The searches for individualWWW, WWZ, WZZ, and ZZZ production are performed in final states with three, four, five, and six leptons (electrons or muons), or with two same-sign leptons plus one or two jets. The observed (expected) significance of the combinedVVV production signal is 5.7 (5.9) standard deviations and the corresponding measured cross section relative to the standard model prediction is 1.02(-0.23)(+0.26). The significances of the individual WWW and WWZ production are 3.3 and 3.4 standard deviations, respectively. Measured production cross sections for the individual triboson processes are also reported

Measurement of the W gamma Production Cross Section in Proton-Proton Collisions at root s=13 TeV and Constraints on Effective Field Theory Coefficients

A fiducial cross section for W gamma production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137 fb(-1) of data collected using the CMS detector at the LHC. The W -> e nu and mu nu decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.Peer reviewe