2 research outputs found
Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids
Naturally occurring flavonoids display
a plethora of different
biological activities, but emerging evidence suggests that this class
of compounds may also act as antidepressant agents endowed with multiple
mechanisms of action in the central nervous system, increasing central
neurotransmission, limiting the reabsorption of bioamines by synaptosomes,
and modulating the neuroendocrine and GABA<sub>A</sub> systems. Due
to their presence in foods, food-derived products, and nutraceuticals,
we established their role and structureâactivity relationships
as reversible and competitive human monoamine oxidase (MAO) inhibitors.
In addition, molecular modeling studies, which evaluated their modes
of MAO inhibition, are presented. These findings could provide pivotal
implications in the quest of novel drug-like compounds and for the
establishment of harmful drugâdietary supplement interactions
commonly reported in the therapy with antidepressant agents
Kaempferol as Selective Human MAOâA Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies
The purpose of this work was to determine
the kaempferol content
in three red wines of Calabria, a southern Italian region with a great
number of certified food products. Considering that wine cultivar,
climate, and soil influence the qualitative and quantitative composition
in flavonoids of Vitis vinifera L.
berries, the three analyzed samples were taken from the 2013 vintage.
Moreover, the Gaglioppo samples, with assigned Controlled Origin Denomination
(DOC), were also investigated in the production of years 2008, 2010,
and 2011. In addition to the analysis of kaempferol, which is present
in higher concentration than in other Italian wines, in vitro assays
were performed to evaluate, for the first time, the inhibition of
the human monoamine oxidases (hMAO-A and hMAO-B). Molecular recognition
studies were also carried out to provide insight into the binding
mode of kaempferol and selectivity of inhibition of the hMAO-A isoform