Ecogeomorphology and vulnerability in a Mediterranean ria-type coast (La Maddalena Archipelago, NE Sardinia, western Mediterranean)

This paper presents a map describing the main geomorphological and sedimentological features, hydrodynamics, benthic habitat distributions and human impact on the coastal and marine areas of the Archipelago of La Maddalena (NE Sardinia, western Mediterranean). This cartography is based on an interdisciplinary sea-land approach, with the aim being to support sustainable and successful beach management in the face of a changing climate and environment, thereby contributing to the achievement of the Agenda 2030 Sustainable Development Goals (13, 14 and 15). In the Main Map (1:14,000 scale), the static and dynamic features of the beach systems and adjacent inner shelf are divided into thematic sections that include the geomorphological elements, hydrodynamics, sedimentological distributions, benthic habitat (mainly Posidonia oceanica meadow) and anthropogenic impacts. The map establishes a fundamental, multidisciplinary benchmark that is able to provide substantial scientific support to policymakers in relation to future vulnerability-assessment activities and the definition of land-management strategies

Geomorphology, beach classification and seasonal morphodynamic transition of a Mediterranean gravel beach (Sardinia, Gulf of Cagliari)

This paper presents an innovative multi-thematic map (1:2500) that integrates morpho-sedimentological data, hydrodynamic processes, seasonal morphodynamic transitions and the distribution of the benthic habitat of a Mediterranean microtidal, wave-dominated gravel beach system. It is part of a larger cartography of coastal areas, and is based on an interdisciplinary sea-land approach that is applicable worldwide and aims to facilitate coastal management practices and future scientific research. The applications to coastal management include: the facilitation of coastal vulnerability assessments; easy-to-access, up-to-date digital geospatial data; and baseline studies for the future assessment and monitoring of environmental changes. The main environmental features that control the marine processes of this gravel beach appear to be linked to geological and morphological contexts such as the presence of the river mouth, the outcropping of a beach-rock along the coastline, the deposition of gravelly sediment in the beachface and the seagrass cover

Natural vs. Anthropic Influence on the Multidecadal Shoreline Changes of Mediterranean Urban Beaches: Lessons from the Gulf of Cagliari (Sardinia)

Urban Mediterranean beaches are often characterized by a fragile and unstable equilibrium that can be easily altered by ongoing climate change and by the increase in human pressure. This may pose serious threats to the survival of beach systems that cannot accommodate these modifications. In this paper, the spatio-temporal shift of the shoreline was investigated along two urban beaches in the Gulf of Cagliari (Poetto and Giorgino; southern Sardinia, western Mediterranean Sea) across a time frame of 62 years (1954–2016). The Digital Shoreline Analysis System (DSAS) ArcGIS™ extension was used to extract different statistical parameters which allowed us to quantify the erosion and accretion rates. These data were further examined in relation to a number of anthropic and natural forcings in order to disentangle the factors controlling shoreline evolution. Eight sectors with interchanging net erosive and accretion trends were identified along the Poetto and Giorgino beaches. In six decades, some sectors of the two study sites appeared to have undergone great shoreline modification as a result of the intense anthropogenic activities impacting these coastal areas. The westernmost portions of both beaches were found to be the most vulnerable to erosion processes; such conditions were likely controlled by the interplaying of local hydrodynamics and by the intense coastal development which affected these sectors. The highest retreat rates (mean end point rate (EPR) = −0.51/year) were recorded in the western limit of Giorgino beach. Along the western limit of Poetto beach, EPR erosion rates (mean EPR = −2.92/year) considerably increased in the years after the artificial beach nourishment carried out in 2002, suggesting that the majority of the nourished material was lost offshore or partly redistributed along the beach. Coastal structures, urban development, river catchment modification, industrial and port activities, beach cleaning and touristic and recreational activities have been identified as the ongoing causes of coastal alteration. If these factors remain constant, under projected climate change scenarios, these beaches are at risk of further increased flooding and erosion. In this context, the application of DSAS appeared as an essential tool, supporting a monitoring system able to provide understanding and, potentially, predictions of the short- to long-term evolution of these beach system

Brodalumab for the treatment of plaque psoriasis in a real-life setting: a 3 years multicenter retrospective study—IL PSO (Italian landscape psoriasis)

Introduction: Brodalumab is a monoclonal antibody that targets the subunit A of the interleukin-17A receptor (IL17RA), inhibiting the signaling of various isoforms of the IL-17 family. It has been approved for the treatment of moderate-to-severe plaque psoriasis after being evaluated in three Phase-3 trials. However, long-term data on brodalumab in a real-life setting are still limited

Geomorphology and sedimentology of Porto Pino, SW Sardinia, Western Mediterranean

This paper presents a detailed (1:4000) geomorphological, sedimentological and ecological map of a Mediterranean microtidal wave-dominated beach system and adjacent inner shelf. This map is an innovative cartographic product that integrates a range of processes of present and past timeframes. It is part of a larger cartography on the coastal geomorphology of Sardinia (Italy) aiming to facilitate coastal management practices and future scientific research. The study area is located in SW Sardinia (Italy), and focuses on Porto Pino beach, an important tourist destination of semi-pristine nature, facing environmental pressures common to many coastal Mediterranean settings. In this context, the main human impact on coastal dune habitats is described and a full environmental characterization of the beach system is presented

Effectiveness, Tolerability, and Drug Survival of Risankizumab in a Real-World Setting: A Three-Year Retrospective Multicenter Study—IL PSO (ITALIAN LANDSCAPE PSORIASIS)

Background: Risankizumab is a humanized monoclonal antibody that selectively inhibits interleukin-23. It has been approved for moderate-to-severe plaque psoriasis and has shown efficacy and safety in clinical trials and real-world experiences. This study aimed to evaluate the long-term effectiveness, safety, and drug survival of risankizumab in a real-life setting. Materials and Methods: We included patients treated with risankizumab from January 2019 to February 2023. A Psoriasis Area and Severity Index score (PASI) was collected at weeks 0, 16, 28, 52, 104, and 156, when available. The occurrence of any adverse events was recorded at each visit. Results: We enrolled 1047 patients. At week 52, a ≥90% improvement in PASI was observed in 81.44% of patients, with a continuous improvement throughout the study (88.99% and 99.07% at weeks 104 and 156, respectively). After three years of treatment, all patients involving the scalp, palms/soles, and genitalia and 95% of patients with nail psoriasis achieved a complete or almost complete skin clearance. No significant safety findings were observed, and 90.73% of the patients were still on treatment after 36 months. Conclusions: This study supports the long-term effectiveness and safety of risankizumab in a real- world setting, even in patients involving difficult-to-treat areas