Additional file 1: Table S1. of The 23-year tracking of blood lipids from adolescence to adulthood in Korea: the Kangwha study

Comparison of baseline characteristics (at 12 years) between participants who were followed up to adulthood and those who withdrew before adulthood. (DOCX 28 kb

Additional file 1: of Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

Study questionnaires used in the JSHS study. The supplementary file contains questionnaires about alcohol intake, smoking, physical activity, and socioeconomic status. (DOCX 269 kb

Additional file 1: of Comparison of intraoperative handling and wound healing between (NEOSORBÂŽ plus) and coated polyglactin 910 suture (NEOSORBÂŽ): a prospective, single-blind, randomized controlled trial

Raw data of study; Raw data of Comparison Between NEOSORB Plus and NEOSORB. (XLSX 39 kb

National trends in asthma prevalence in South Korea before and during the COVID-19 pandemic 1998-2021

To the Editor,Since the COVID-19 pandemic has a drastic effect on diverse allergic diseases, research on the critical impact of COVID-19 on asthma has been highlighted internationally. According to previous studies, the prevalence of asthma increased worldwide over the past decades due to pandemic.1, 2 However, previous studies reported in South Korea have conflicting evidence on whether the prevalence of asthma has decreased or increased, especially among adolescents.3 Thus, to further understand the context of this extraordinary trend, we examined the trends of age-stratified asthma prevalence in South Koreans before and during the COVID-19 pandemic.4 The effects of age and other socioeconomic and environmental variables on these trends were analysed using data collected from the Korean National Health and Nutrition Examination Survey (KNHANES), 1998–2021.5 An annual survey conducted by the Korea Disease Control and Prevention Agency (KDCA), 1998–2021...</p

Global and regional burden of vaccine-induced thrombotic thrombocytopenia, 1969-2023: comprehensive findings with critical analysis of the WHO international pharmacovigilance database

Objective: The scarcity of studies on vaccine-induced thrombosis and thrombocytopenia syndrome (TTS) limits the comprehensive understanding of vaccine safety on a global scale. Therefore, the objective of this study is to assess the global burden of vaccine-induced TTS, identify the vaccines most associated with it, and suggest clinical implications regarding vaccination. Methods: This study employed the World Health Organization international pharmacovigilance database, extracting records of vaccine-induced immune thrombotic thrombocytopenia from 1969 to 2023 (total reports, n > 130 million). Global reporting counts, reported odds ratios (ROR), and information components (IC) were calculated to identify the association between 19 vaccines and the occurrence of vaccine-induced TTS across 156 countries. Results: We identified 24 233 cases (male, n = 11 559 [47.7%]) of vaccine-induced TTS among 404 388 reports of all-cause TTS. There has been a significant increase in reports of vaccine-induced TTS events over time, with a noteworthy surge observed after 2020, attributed to cases of TTS associated with COVID-19 vaccines. Measles, mumps, and rubella (MMR) vaccines were associated with most TTS reports (ROR [95% confidence interval], 2.87 [2.75–3.00]; IC [IC0.25], 1.51 [1.43]), followed by hepatitis B (HBV, 2.23 [2.07–2.39]; 1.15 [1.03]), rotavirus diarrhea (1.95 [1.78–2.13]; 0.81 [0.53]), encephalitis (1.80 [1.50–2.16]; 0.84 [0.53]), hepatitis A (1.67 [1.50–1.86]; 0.73 [0.55]), adenovirus Type 5 vector-based (Ad5-vectored) COVID-19 (1.64 [1.59–1.68]; 0.69 [0.64]), pneumococcal (1.57 [1.49–1.66]; 0.65 [0.56]), and typhoid vaccines (1.41 [1.12–1.78]; 0.49 [0.11]). Concerning age and sex-specific risks, reports of vaccine-induced TTS were more associated with females and younger age groups. The age group between 12 and 17 years exhibited significant sex disproportion. Most of these adverse events had a short time to onset (days; mean [SD], 4.99 [40.30]) and the fatality rate was 2.20%, the highest rate observed in the age group over 65 years (3.79%) and lowest in the age group between 0 and 11 years (0.31%). Conclusion: A rise in vaccine-induced TTS reports, notably MMR, HBV, and rotavirus diarrhea vaccines, was particularly related to young females. Ad5-vectored COVID-19 vaccines showed comparable or lower association with TTS compared to other vaccines. Despite the rarity of these adverse events, vigilance is essential as rare complications can be fatal, especially in older groups. Further studies with validated reporting are imperative to improve the accuracy of assessing the vaccine-induced TTS for preventive interventions and early diagnosis.</p