ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

ASXL1 is frequently mutated in a spectrum of myeloid malignancies with poor prognosis. Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice; however, the underlying molecular mechanisms remain unclear. We report that ASXL1 interacts with the cohesin complex, which has been shown to guide sister chromatid segregation and regulate gene expression. Loss of Asxl1 impairs the cohesin function, as reflected by an impaired telophase chromatid disjunction in hematopoietic cells. Chromatin immunoprecipitation followed by DNA sequencing data revealed that ASXL1, RAD21, and SMC1A share 93% of genomic binding sites at promoter regions in Lin-cKit+ (LK) cells. We have shown that loss of Asxl1 reduces the genome binding of RAD21 and SMC1A and alters the expression of ASXL1/cohesin target genes in LK cells. Our study underscores the ASXL1-cohesin interaction as a novel means to maintain normal sister chromatid separation and regulate gene expression in hematopoietic cells

A rate control method based on wavelet transform(一种基于HVS的码率控制方法)

本文在小波分解图像的不同级上采用不同长度的滤波器以消减“振铃”效应，然后重新组织小波系数成小波块，根据每个小波块所含能量的多少给其分配不同的码率.最后根据人体视觉系统(HVS)的特点，提出了一种码率控制方法

Dyadic affine wavelet packet(二进仿射小波包)

自从小波包概念提出以来,关于这一方面的研究吸引了许多数学家的兴趣.到目前为止,在L2(RS)中关于正交与非正交小波包、可分与非可分小波包的研究已取得丰硕的成果,其中S是一给定的自然数.CHUI和LI在R上有界一致连续函数空间上引入了插值多分辨分析的概念并给出了这一空间函数的二进仿射小波分解.本文在这一空间引入并利用泛函小波变换研究了二进仿射小波包,对这一空间的任一函数,给出了逐点收敛的二进仿射小波包分解

Studies on the high frequency plant regeneration from indica rice immature embryos and its transformation using biolistic method(籼稻幼胚组织培养高频率植株再生及其基因转化的研究)

以籼稻品种特青的幼胚作为外植体，研究了激素对愈伤组织诱导及植株再生的影响。MS+2,4-D 2 mg/L作培养基，愈伤组织诱导率达100%；愈伤组织在MS + KT 3 mg/L + NAA 0.5 mg/L的培养基上，分化频率为67.3%；在此基础上利用基因枪转化技术，将外源的bar基因导入了水稻基因组，转基因植株表现出对除草剂Basta很强的抗性