Assessment of Vitamin A Status of Preschool Children in a Sub-Saharan African Setting: Comparative Advantage of Modified Relative-dose Response Test

A nationally-representative sample of 2,696 preschool children living in Congo was examined during August-September 2003 to determine the rates of vitamin A deficiency. Ninety clusters of 30 children, aged six months to six years, were selected, using a randomized two-level cluster-sampling method. Vitamin A deficiency was determined by assessing the prevalence of active xerophthalmia (nightblindness and/or Bitot spots) in the cross-over sample of 2,696 individuals. A semi-quantitative seven-day dietary questionnaire was concurrently applied to the mothers of children enrolled to estimate the latter's consumption of vitamin A-rich food. Vitamin A status was assessed by performing the modified relative dose-response test (MRDR) on dried blood spots (DBS) from a subsample of 207 children aged less than six years and the impression cytology with transfer (ICT) test on a subsample of 1,162 children. Of the children enrolled, 5.2% suffered from nightblindness, 8.0% had Bitot spots, and 2.5% had other vitamin A deficiency sequellae. Fifty-three percent of the ICT tests showed the presence of vitamin A deficiency. The biochemical MRDR test showed that the vitamin A status of 30% of the study children was critical. Twenty-seven of them had retinol levels of <10 μg/dL [mean±standard deviation (SD) 7.02±2.0 μg/dL], and 50% had retinol levels of 10-20 μg/dL (mean±SD 14.2±2.83 μg/dL). The poor health status and low rates of consumption of vitamin A-rich food are the main factors determining critical status. Vitamin A deficiency, reflecting poor nutrition and health, is a serious public-health issue among children aged less than six years in Congo

Dynamics of an Idealized Fluid Model for Investigating Convective-scale Data Assimilation

An idealized fluid model of convective-scale numerical weather prediction, intended for use in inexpensive data assimilation experiments, is described here and its distinctive dynamics are investigated. The model modifies the rotating shallow water equations to include some simplified dynamics of cumulus convection and associated precipitation, extending and improving the model of Würsch and Craig. Changes to this original model are the removal of ad hoc diffusive terms and the addition of Coriolis rotation terms, leading to a so-called 1.5-dimensional model. Despite the non-trivial modifications to the parent equations, it is shown that this shallow water type model remains hyperbolic in character and can be integrated accordingly using a discontinuous Galerkin finite element method for nonconservative hyperbolic systems of partial differential equations. Combined with methods to ensure well-balancedness and non-negativity, the resulting numerical solver is novel, efficient and robust. Classical numerical experiments in the shallow water theory, such as the Rossby geostrophic adjustment and flow over topography, are reproduced for the standard shallow water model and used to highlight the modified dynamics of the new model. In particular, it exhibits important aspects of convective-scale dynamics relating to the disruption of large-scale balance and is able to simulate other features related to convecting and precipitating weather systems. Our analysis here and preliminary results suggest that the model is well suited for efficiently and robustly investigating data assimilation schemes in an idealized ‘convective-scale’ forecast assimilation framework

Assessment of vitamin A status of preschool children in a sub-Saharan African setting: Comparative advantage of modified relative-dose response test

A nationally-representative sample of 2, 696 preschool children living in Congo was examined during Au-gust-September 2003 to determine the rates of vitamin A deficiency. Ninety clusters of 30 children, aged six months to six years, were selected, using a randomized two-level cluster-sampling method. Vitamin A deficiency was determined by assessing the prevalence of active xerophthalmia (nightblindness and/or Bitot spots) in the cross-over sample of 2, 696 individuals. A semi-quantitative seven-day dietary question-naire was concurrently applied to the mothers of children enrolled to estimate the latter\u2032s consumption of vitamin A-rich food. Vitamin A status was assessed by performing the modified relative dose-response test (MRDR) on dried blood spots (DBS) from a subsample of 207 children aged less than six years and the im-pression cytology with transfer (ICT) test on a subsample of 1, 162 children. Of the children enrolled, 5. 2% suffered from nightblindness, 8. 0% had Bitot spots, and 2. 5% had other vitamin A deficiency sequellae. Fifty-three percent of the ICT tests showed the presence of vitamin A deficiency. The biochemical MRDR test showed that the vitamin A status of 30% of the study children was critical. Twenty-seven of them had retinol levels of &lt; 10 \u3bcg/dL [mean\ub1standard deviation (SD) 7. 02\ub1 2. 0 \u3bcg/dL], and 50% had retinol levels of 10- 20 \u3bcg/dL (mean\ub1SD 14. 2\ub1 2. 83 \u3bcg/dL). The poor health status and low rates of consumption of vitamin A-rich food are the main factors determining critical status. Vitamin A deficiency, reflecting poor nutrition and health, is a serious public-health issue among children aged less than six years in Congo

Modified embedded-atom method interatomic potentials for the Mg-Al alloy system

We developed new modified embedded-atom method (MEAM) interatomic potentials for the Mg-Al alloy system using a first-principles method based on density functional theory (DFT). The materials parameters, such as the cohesive energy, equilibrium atomic volume, and bulk modulus, were used to determine the MEAM parameters. Face-centered cubic, hexagonal close packed, and cubic rock salt structures were used as the reference structures for Al, Mg, and MgAl, respectively. The applicability of the new MEAM potentials to atomistic simulations for investigating Mg-Al alloys was demonstrated by performing simulations on Mg and Al atoms in a variety of geometries. The new MEAM potentials were used to calculate the adsorption energies of Al and Mg atoms on Al (111) and Mg (0001) surfaces. The formation energies and geometries of various point defects, such as vacancies, interstitial defects and substitutional defects, were also calculated. We found that the new MEAM potentials give a better overall agreement with DFT calculations and experiments when compared against the previously published MEAM potentials.Comment: Fixed a referenc

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Objective. This study examined the association between obstructive sleep apnea (OSA), daytime sleepiness, functional activity, and objective physical activity. Setting. Subjects (N = 37) being evaluated for OSA were recruited from a sleep clinic. Participants. The sample was balanced by gender (53% male), middle-aged, primarily White, and overweight or obese with a mean BMI of 33.98 (SD = 7.35; median BMI = 32.30). Over 40% reported subjective sleepiness (Epworth Sleepiness Scale (ESS) ≥10) and had OSA (78% with apnea + hypopnea index (AHI) ≥5/hr). Measurements. Evaluation included questionnaires to evaluate subjective sleepiness (ESS) and functional outcomes (Functional Outcomes of Sleep Questionnaire (FOSQ)), an activity monitor, and an overnight sleep study to determine OSA severity. Results. Increased subjective sleepiness was significantly associated with lower scores on the FOSQ but not with average number of steps walked per day. A multiple regression analysis showed that higher AHI values were significantly associated with lower average number of steps walked per day after controlling patient&apos;s age, sex, and ESS. Conclusion. Subjective sleepiness was associated with perceived difficulty in activity but not with objectively measured activity. However, OSA severity was associated with decreased objective physical activity in aging adults

Proportions of Convective and Stratiform Precipitation Revealed in Water Isotope Ratios

Tropical and midlatitude precipitation is fundamentally of two types, spatially-limited and high-intensity convective or widespread and lower-intensity stratiform, owing to differences in vertical air motions and microphysical processes governing rain formation. These processes are difficult to observe or model and precipitation partitioning into rain types is critical for understanding how the water cycle responds to climate changes. Here, we combine two independent data sets – convective and stratiform precipitation fractions, derived from the Tropical Rainfall Measuring Mission satellite or synoptic cloud observations, and stable isotope and tritium compositions of surface precipitation, derived from a global network – to show that isotope ratios reflect rain type proportions and are negatively correlated with stratiform fractions. Condensation and riming associated with boundary layer moisture produces higher isotope ratios in convective rain, along with higher tritium when riming in deep convection occurs with entrained air at higher altitudes. Based on our data, stable isotope ratios can be used to monitor changes in the character of precipitation in response to periodic variability or changes in climate. Our results also provide observational constraints for an improved simulation of convection in climate models and a better understanding of isotope variations in proxy archives, such as speleothems and tropical ice

LC determination of propylene glycol in human plasma after pre-column derivatization with benzoyl chloride

A simple high-performance liquid chromatographic method, using photodiode array detection was developed for the determination of propylene glycol in human plasma and in the fluid retreived after continuous veno-venous hemofiltration. The method entailed alkaline derivatization with benzoyl chloride and ethylene glycol as internal standard. The separation of the compounds, after extraction with pentane, was carried out on a Pursuit C8 column with UV-detection at 230 nm. Validation samples were analyzed with an accuracy between 95 and 105%, and intra- and inter-day coefficients of variation of less than 8%. The calibration curve was linear over a concentration range of 5-100 mg

TRMM Latent Heating Retrieval and Comparisons with Field Campaigns and Large-Scale Analyses

Rainfall production is a fundamental process within the Earth's hydrological cycle because it represents both a principal forcing term in surface water budgets, and its energetics corollary, latent heating (LH), is one of the principal sources of atmospheric diabatic heating. Latent heat release itself is a consequence of phase changes between the vapor, liquid, and frozen states of water. The vertical distribution of LH has a strong influence on the atmosphere, controlling large-scale tropical circulations, exciting and modulating tropical waves, maintaining the intensities of tropical cyclones, and even providing the energetics of midlatitude cyclones and other mobile midlatitude weather systems. Moreover, the processes associated with LH result in significant non-linear changes in atmospheric radiation through the creation, dissipation and modulation of clouds and precipitation. Yanai et al. (1973) utilized the meteorological data collected from a sounding network to present a pioneering work on thermodynamic budgets, which are referred to as the apparent heat source (Q1) and apparent moisture sink (Q2). Yanai's paper motivated the development of satellite-based LH algorithms and provided a theoretical background for imposing large-scale advective forcing into cloud-resolving models (CRMs). These CRM-simulated LH and Q1 data have been used to generate the look-up tables used in LH algorithms. This paper examines the retrieval, validation, and application of LH estimates based on rain rate quantities acquired from the Tropical Rainfall Measuring Mission satellite (TRMM). TRMM was launched in November 1997 as a joint enterprise between the American and Japanese space agencies -- with overriding goals of providing accurate four-dimensional estimates of rainfall and LH over the global Tropics and subtropics equatorward of 35o. Other literature has acknowledged the achievement of the first goal of obtaining an accurate rainfall climatology. This paper describes the second major goal of obtaining credible LH estimates as well as their applications within TRMM's zone of coverage, the standard TRMM LH products, and areas for further improvement

Characterization of silicon heterojunctions for solar cells

Conductive-probe atomic force microscopy (CP-AFM) measurements reveal the existence of a conductive channel at the interface between p-type hydrogenated amorphous silicon (a-Si:H) and n-type crystalline silicon (c-Si) as well as at the interface between n-type a-Si:H and p-type c-Si. This is in good agreement with planar conductance measurements that show a large interface conductance. It is demonstrated that these features are related to the existence of a strong inversion layer of holes at the c-Si surface of (p) a-Si:H/(n) c-Si structures, and to a strong inversion layer of electrons at the c-Si surface of (n) a-Si:H/(p) c-Si heterojunctions. These are intimately related to the band offsets, which allows us to determine these parameters with good precision