875 research outputs found
Calibration Methods of Laser-Induced Breakdown Spectroscopy
Laser-induced breakdown spectroscopy (LIBS) has gained great attention over the past two decades due to its many advantages, such as needless sample preparation, capability of remote measurement and fast multielement simultaneous analysis. However, because of its inherent uncertainty features of plasma, it is still a big challenge for LIBS community worldwide to realize high sensitivity and accurate quantitative analysis. Currently, many chemometric analytical methods have been applied to LIBS calibration analysis, including univariate regression, multivariate regression, principal component regression (PCR), partial least squares regression (PLSR) and so on. In addition, appropriate sample and spectral pretreatment can effectively improve the analytical performance (i.e., limit of detection (LOD), accuracy and repeatability) of LIBS. In this chapter, we briefly summarize the progress of these calibration methods and their applications on LIBS and provide our recommendations
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Cancer Cell-Derived Clusterin Modulates the Phosphatidylinositol 3'-Kinase-Akt Pathway through Attenuation of Insulin-Like Growth Factor 1 during Serum Deprivation
Cancer cells in their respective microenvironments must endure various growth-constraining stresses. Under these conditions, the cancer cell-derived factors are thought to modulate the signaling pathways between cell growth and dormancy. Here, we describe a cancer cell-derived regulatory system that modulates the phosphatidylinositol 3'-kinase (PI3K)-Akt pathway under serum deprivation stress. Through the use of biochemical purification, we reveal that cancer cell-secreted insulin-like growth factor 1 (IGF-1) and clusterin, an extracellular stress protein, constitute this regulatory system. We show that secreted clusterin associates with IGF-1 and inhibits its binding to the IGF-1 receptor and hence negatively regulates the PI3K-Akt pathway during serum deprivation. This inhibitory function of clusterin appears to prefer IGF-1, as it fails to exert any effects on epidermal growth factor signaling. We demonstrate furthermore that the constitutive activation of oncogenic signaling downstream of IGF-1 confers insensitivity to the inhibitory effects of clusterin. Thus, the interplay between cancer cell-derived clusterin and IGF-1 may dictate the outcome of cell growth and dormancy during tumorigenic progression
New Impossible Differential Attacks of Reduced-Round Camellia-192 and Camellia-256
Camellia is a block cipher selected as a standard by ISO/IEC, which has been
analyzed by a number of cryptanalysts. In this paper, we propose several
6-round impossible differential paths of Camellia with the layer
in the middle of them. With the impossible differential and a well-organized precomputational table, impossible differential attacks on 10-round Camellia-192 and
11-round Camellia-256 are given, and the time
complexity are and respectively. An impossible differential
attack on 15-round Camellia-256 without layers and whitening is also be given,
which needs about encryptions. To the best of our
knowledge, these are the best cryptanalytic results of Camellia-192/-256 with layers and Camellia-256 without layers to date
Near-Collision Attack on the Step-Reduced Compression Function of Skein-256
The Hash function Skein is one of the 5 finalists of NIST SHA-3
competition. It is designed based on the threefish block cipher and
it only uses three primitive operations: modular addition, rotation
and bitwise XOR (ARX). In this paper, we combine two short
differential paths to a long differential path using the modular
differential technique. And we present the semi-free start
near-collision attack up to the 32-step Skein-256 with the Hamming
difference 51. The complexity of our attack is about
Chemical Synthesis and Applications of Colloidal Metal Phosphide Nanocrystals
Colloidal nanocrystals (NCs) have emerged as promising materials in optoelectronic devices and biological imaging application due to their tailorable properties through size, shape, and composition. Among these NCs, metal phosphide is an important class, in parallel with metal chalcogenide. In this review, we summarize the recent progress regarding the chemical synthesis and applications of colloidal metal phosphide NCs. As the most important metal phosphide NCs, indium phosphide (InP) NCs have been intensively investigated because of their low toxicity, wide and tunable emission range from visible to the near-infrared region. Firstly, we give a brief overview of synthetic strategies to InP NCs, highlighting the benefit of employing zinc precursors as reaction additive and the importance of different phosphorus precursors to improve the quality of the InP NCs, in terms of size distribution, quantum yield, colloidal stability, and non-blinking behavior. Next, we discuss additional synthetic techniques to overcome the issues of lattice mismatch in the synthesis of core/shell metal phosphide NCs, by constructing an intermediate layer between core/shell or designing a shell with gradient composition in a radial direction. We also envision future research directions of InP NCs. The chemical synthesis of other metal phosphide NCs, such as II–V metal phosphide NCs (Cd3P2, Zn3P2) and transition metal phosphides NCs (Cu3P, FeP) is subsequently introduced. We finally discuss the potential applications of colloidal metal phosphide NCs in photovoltaics, light-emitting diodes, and lithium ion battery. An overview of several key applications based on colloidal metal phosphide NCs is provided at the end
Genetic immunization with Hantavirus vaccine combining expression of G2 glycoprotein and fused interleukin-2
In this research, we developed a novel chimeric HTNV-IL-2-G2 DNA vaccine plasmid by genetically linking IL-2 gene to the G2 segment DNA and tested whether it could be a candidate vaccine. Chimeric gene was first expressed in eukaryotic expression system pcDNA3.1 (+). The HTNV-IL-2-G2 expressed a 72 kDa fusion protein in COS-7 cells. Meanwhile, the fusion protein kept the activity of its parental proteins. Furthermore, BALB/c mice were vaccinated by the chimeric gene. ELISA, cell microculture neutralization test in vitro were used to detect the humoral immune response in immunized BALB/c mice. Lymphocyte proliferation assay was used to detect the cellular immune response.- The results showed that the chimeric gene could simultaneously evoke specific antibody against G2 glycoprotein and IL-2. And the immunized mice of every group elicited neutralizing antibodies with different titers. Lymphocyte proliferation assay results showed that the stimulation indexes of splenocytes of chimeric gene to G2 and IL-2 were significantly higher than that of other groups. Our results suggest that IL-2-based HTNV G2 DNA can induce both humoral and cellular immune response specific for HTNV G2 and can be a candidate DNA vaccine for HTNV infection
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