State of the art for the detection of red lesions.

<p>*MESSIDOR dataset.</p><p>**ROC dataset.</p

Composition of the cross-dataset training and testing.

<p>*The annotations SH and DH are added to form the training set in DR1, summing 180 images due to the overlap.</p

Accuracy for Training with DR1, Testing with Messidor.^*

<p>*AUC in %; best accuracy is shown in bold.</p

Regions of interest (dashed black regions) and the points of interest (blue circles).

<p>Points of interest falling within the regions marked by the specialist are considered for creating the class-aware codebook – half of the codebook is learned from local features sampled inside the regions marked as lesions, and half the codebook is learned from local features outside those regions.</p

Relation between grades of neoplasia and normal epithelium.

<p>(A) Multifractal spectra and (B) Box plots of box counting dimension <i>d_BOX</i>.</p

Standardized AUCs per lesion, for six combinations of feature extraction and coding (horizontal axis).

<p>In the box-plots (black), the whiskers show the range up to 1.5× the interquartile range, and outliers are shown as small circles. Averages (small squares) and 95%-confidence intervals (error bars) are also shown, in red, for the same data. The strong synergy between sparse feature extraction and semi-soft coding is evident: it has consistently improved results for all lesions, while the other combinations improve the results of some lesions at the cost of decreasing it for other lesions (as shown by the spread of the standardized effects in the vertical axis). This plot is based on a balanced design with the DR2 dataset and all lesions, the other balanced design with both datasets and two lesions show similar results.</p

Accuracy for Training with DR1, Testing with DR2.^*

<p>*AUC in %; best accuracy is shown in bold.</p

Confusion matrix comparing pathologist's results for low-grade and high grade neoplasia and predicted group by box counting dimension <i>d_BOX</i>.

<p>Confusion matrix comparing pathologist's results for low-grade and high grade neoplasia and predicted group by box counting dimension <i>d_BOX</i>.</p

The BoVW model illustrated as a matrix.

<p>The figure highlights the relationship between the low-level features <b>x</b><i>_j</i>, the codewords <b>c</b><i>_m</i> of the visual dictionary, the encoded features <i>α_m</i>, the coding function <i>f</i> and the pooling function <i>g</i>.</p

Annotation occurrences for the three datasets.

<p>*“Red Lesion” is a more general annotation that encompasses both SH and DH, besides microaneurysms.</p><p>**The lesions do not sum to this value because an image can present several types of lesion at once.</p