Mechanical Elongation of the Small Intestine: Evaluation of Techniques for Optimal Screw Placement in a Rodent Model

Introduction. The aim of this study was to evaluate techniques and establish an optimal method for mechanical elongation of small intestine (MESI) using screws in a rodent model in order to develop a potential therapy for short bowel syndrome (SBS). Material and Methods. Adult female Sprague Dawley rats (n=24) with body weight from 250 to 300 g (Σ=283) were evaluated using 5 different groups in which the basic denominator for the technique involved the fixation of a blind loop of the intestine on the abdominal wall with the placement of a screw in the lumen secured to the abdominal wall. Results. In all groups with accessible screws, the rodents removed the implants despite the use of washers or suits to prevent removal. Subcutaneous placement of the screw combined with antibiotic treatment and dietary modifications was finally successful. In two animals autologous transplantation of the lengthened intestinal segment was successful. Discussion. While the rodent model may provide useful basic information on mechanical intestinal lengthening, further investigations should be performed in larger animals to make use of the translational nature of MESI in human SBS treatment

Vergleichende biomechanische und mikro-computertomographische Untersuchung des Einheilverhaltens bioresorbierbarer Magnesium-Pins und konventioneller Titan-Implantate im transkortikalen Rattenmodell

Recently, Haesevoets, Folmer, and Van Hiel (2015) strongly questioned the comparability and equivalence of different mixed–motive situations as modelled in economic games. Particularly, the authors found that different game correlated only weakly on average and loaded on two separate factors. In turn, personality traits failed to consistently account for behavioural tendencies across games. Contrary to the conclusions of Haesevoets et al., these findings are actually perfectly in line with the game–theoretic understanding of the different economic games. If one considers the variety of specific motives underlying decisions in different games, Haesevoets et al.'s findings actually support the validity of different games rather than questioning it. This, in turn, emphasizes the necessity for the plethora of different games that have been developed over decades in economics and psychology