3,117 research outputs found
Women's Health, Economic Health: A Cross-National Study of Nine sub-Saharan Countries
This article analyzes whether a country's investment in comprehensive women's healthcare translates into increased economic growth and economic output. Very few studies consider the possible direct correlation between the physical health of a country's women and a country's economic productivity. This study fills part of this gap by examining the health status of women in nine sub-Saharan African countries, using World Health Organization data over various time periods dependent on data availability. Health status was then compared to each country's economic growth, derived from measures of Gross Domestic Product (GDP), Gross National Income (GNI), and the Human Development Index (HDI). The data show that where women's health status is high, economic growth is high, and where women's health status is low, economic growth is low. In conclusion, we must ensure women's health, not only for the sake of ethics, but also for the sake of building economically strong countries where all people can thrive
Evaluation of the Overall Binding of Acetohexamide and Tolbutamide with Methyl Glyoxal-Modified HSA by High-Performance Affinity Chromatography
High performance affinity chromatography (HPAC) was used in a zonal competition format to investigate the overall binding of two sulfonylurea drugs with modified human serum albumin (HSA). The in vitro modifications of this protein that were examined included glycation, as occurs in the presence of elevated glucose levels during diabetes, and the formation of advanced glycation end-products (AGEs) due to the reaction of HSA with methylglyoxal (MGo). The sulfonylurea drugs acetohexamide and tolbutamide, which are used to treat type II diabetes, were each injected onto 10 mm x 2.1 mm i.d. affinity microcolumns that contained normal HSA and HSA modified with MGo. Competition studies based on a zonal elution format were carried out by using R-warfarin as a site âspecific probe for Sudlow site I of HSA and L-tryptophan as a site-specific probe for Sudlow site II. The studies were performed with eight mobile phase concentrations of the drugs, ranging from 0-25 ”M, and at a flowrate of 0.5 mL/min and a temperature of 37°C. The resulting information made it possible to determine the site-specific association equilibrium constants for each drug with normal and modified HSA. A decrease of approximately 0.4-fold to 0.8-fold in binding strength was found when comparing normal HSA vs control MGo-modified HSA and normal HSA vs diabetic MGo-modified HSA. These experiments illustrated how affinity microcolumns and zonal competition could be used in detailed studies of interactions by sulfonylurea drugs with normal HSA and modified forms of this protein. Such information may be useful in future applications within the field of personalized medicine for the development of customized treatments for patients with type II diabetes
Adenosine-induced ST segment depression with normal perfusion
Background: Intravenous adenosine in conjunction with myocardial perfusion imaging is
commonly used for the detection of coronary artery disease and risk assessment. We have
previously shown that patients with ischemic changes on the 12-lead electrocardiogram (ECG)
in response to adenosine but with normal perfusion pattern have a benign outcome on shortintermediate
follow-up. The long-term outcome of these patients is unknown.
Methods: Patients with ischemic ECG response (≥ 1 mm ST depression) to adenosine
infusion but with normal perfusion on single-photon emission computed tomography (SPECT)
imaging in the absence of a history of myocardial infarction or coronary revascularization
were followed up for mortality, myocardial infarctions, and coronary revascularization.
Results: The cohort consisted of 73 patients (81% women) who were followed up for mortality
for a mean of 61 ± 15 months. There were 10 deaths, and the cause of death was determined to be
non-cardiac in half of those. Follow-up for the other endpoints was complete for 21 ± 10 months
during which no patient had myocardial infarction and seven underwent coronary
revascularization.
Conclusions: Patients with ischemic ECG response to intravenous adenosine administration
and normal perfusion on SPECT are at low risk of cardiovascular events. The ST segment
response to adenosine in this setting is likely related to non-ischemic mechanisms
User`s guide to REVERT. A CDC 7600 program for converting Spent Fuel Test - Climax data to engineering units, with corrections
A CDC 7600 computer program, REVERT, can revise Spent Fuel Test - Climax data files using one of several algorithms, depending on the type of data. The algorithms use coefficients from a separate file organized by data type identifiers. REVERT can also make that file of coefficients, using data from tapes made by Hewlett-Packard equipment employed for data acquisition on the spent Fuel Test - Climax at NTS. 12 references
Synthesis and characterisation of ruthenium complexes containing a pendent catechol ring
A series of [Ru(bipy)âL]âș and [Ru(phen)âL]âș complexes where L is 2-[5-(3,4-dimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine (HL1) and 4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)benzene-1,2-diol (HL2) are reported. The compounds obtained have been characterised using X-ray crystallography, NMR, UV/Vis and emission spectroscopies. Partial deuteriation is used to determine the nature of the emitting state and to simplify the NMR spectra. The acid-base properties of the compounds are also investigated. The electronic structures of [Ru(bipy)âL1]âș and Ru(bipy)âHL1]ÂČâș are examined using ZINDO. Electro and spectroelectrochemical studies on [Ru(bipy)â(L2)]âș suggest that proton transfer between the catechol and triazole moieties on L2 takes place upon oxidation of the L2 ligand
Experimental characterization of frequency dependent squeezed light
We report on the demonstration of broadband squeezed laser beams that show a
frequency dependent orientation of the squeezing ellipse. Carrier frequency as
well as quadrature angle were stably locked to a reference laser beam at
1064nm. This frequency dependent squeezing was characterized in terms of noise
power spectra and contour plots of Wigner functions. The later were measured by
quantum state tomography. Our tomograph allowed a stable lock to a local
oscillator beam for arbitrary quadrature angles with one degree precision.
Frequency dependent orientations of the squeezing ellipse are necessary for
squeezed states of light to provide a broadband sensitivity improvement in
third generation gravitational wave interferometers. We consider the
application of our system to long baseline interferometers such as a future
squeezed light upgraded GEO600 detector.Comment: 8 pages, 8 figure
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