MUITO ALÉM DO TRADICIONAL VERSUS MODERNO: DILEMAS CONTEMPORÂNEOS NO ESPAÇO RURAL UM ESTUDO DE CASO DO MUNICÍPIO DE ROSÁRIO DO SUL/RS

O estudo teve por objetivo analisar o processo de transformação do espaço rural do município de Rosário do Sul/RS, localizado na campanha gaúcha, atentando para conseqüências do incremento de atividades agrícolas nos convencionais espaços destinados a pecuária extensiva. A pesquisa seguiu as orientações gerais do método Análise-Diagnóstico de Sistemas Agrários e na abordagem crítica da contraposição entre o moderno e o tradicional, e acerca dos supostos benefícios que esta consolidação/substituição pode promover. Entre os principais resultados alcançados destaca-se a desmistificação de alguns mitos tidos pelo senso comum da campanha gaúcha como um espaço homogêneo e pouco dinâmico. No caso de Rosário do Sul, a [nova] organização espacial conjuga a manutenção da estrutura fundiária enraizada e legitimada pela cultura do latifúndio, com a inserção da “moderna” lavoura comercial de arroz e soja e de grandes empreendimentos empresarias na fruticultura e na celulose. Por fim, o estudo permitiu identificar a reorganização espacial fruto das interações entre as velhas formas, representadas pelas grandes propriedades de pecuária extensiva, com o moderno, representado pela entrada das atividades agrícolas empresarias. Contudo, a introdução das lavouras comerciais no espaço rural em questão, continua mantendo as velhas formas, marcadas pela estrutura fundiária altamente concentrada, sem impactar significativamente no desenvolvimento econômica geral da região.--------------------------------------------------------This study aims to analyse the transformation processs of the rural space in the city Rosário do Sul/RS, located in the countryside, focusing on the consequences of the increment of agricultural activities in convencional spaces bounded to the extensive livestock. To do it, we used a critical approach of contraposition between the modern and the tradicional and the supposed benefits that this consolidation/subtitution can promote. This study follows the general orientation of the diagnostic/analysis methods of the Agricultural System. The main results are desmistification of some elements such as the common sense of the gaucho countryside as a homogenous space and the lack of dynamism. In Rosário do Sul case, the [new] spatial organization conjugate the manutention of a well-established and acceptable agricultural structure by the culture with the insertation of relatively new and enterprised activities represented by soybeans and rice planting, as well as the insertation of orcharding (fruit growing) and its derivates. At last, the zones delimitation allowed to visualize the spacial reorganization resulting from old forms of interation represented by the agricultural structure allied with the extensive livestock and the modern represented by the input of agricultural activities. Even though the introduction of agricultural activities, the rural space still keeping its old forms marked by a concentrated agricultural structure (farms and cattle ranch), which do not represent significative economic dynamism to promote the city development in an integrated way.Campanha gaúcha, Desenvolvimento rural, Pecuária extensiva tradicional, Agricultura familiar, gaucho countryside, rural development, tradicional extensive livestock, familiar agriculture, Livestock Production/Industries,

Withdrawal and Re-treatment with Filgotinib in Ulcerative Colitis: Post Hoc Analyses of the Phase 2b/3 SELECTION and SELECTIONLTE Studies

BACKGROUND AND AIMS Maintenance treatment for ulcerative colitis may be discontinued for multiple reasons. This post hoc analysis assessed the efficacy and safety of re-treatment with filgotinib, an oral, once-daily, Janus kinase 1 preferential inhibitor, in the phase 2b/3 SELECTION trial and its long-term extension [LTE] study in ulcerative colitis. METHODS Partial Mayo Clinic Score [pMCS] response and remission were evaluated in patients who received induction with filgotinib 200 mg [FIL200] or 100 mg [FIL100], were randomized to treatment withdrawal [placebo] during maintenance, and following disease worsening, were re-treated with open-label FIL200 in the LTE study. Factors were evaluated for association with pMCS remission at LTE week 12, and safety outcomes were reported. RESULTS Analyses included 86 patients [FIL200: n = 51; FIL100: n = 35]. Median time to disease worsening following treatment withdrawal was 15.1 weeks (95% confidence interval [CI]: 9.1-18.7) for FIL200-induced patients and 9.6 weeks [95% CI: 6.3-12.0] for FIL100-induced patients. Three-quarters [75%] of patients achieved a pMCS response within 4-5 weeks of re-treatment in both groups. At LTE week 48, pMCS remission was achieved by 45.1% and 51.4% of FIL200- and FIL100-induced patients, respectively. Factors independently associated with restoring efficacy included no concomitant use of corticosteroids at induction baseline, and high albumin levels, pMCS remission and endoscopic score at maintenance baseline. No new safety signals were reported among re-treated patients. CONCLUSIONS In induction responders, re-treatment with FIL200 following temporary withdrawal from therapy restores response and/or remission in the majority of patients within 12 weeks. Re-treatment is well-tolerated

O que pensam professores a respeito de avaliação

Este artigo tem por objetivo caracterizar concepções apresentadas por professores de Matemática e Ciências a respeito da avaliação da aprendizagem dos alunos. Os dados para análise provém da aplicação de um questionário respondido por cinco professores participantes de um projeto de formação continuada. Os resultados apontaram que, à exceção de um desses professores, que pareceu demonstrar uma concepção classificatória de avaliação, os demais parecem identificar funções da avaliação para além da classificação, mostrando compreender a necessidade de se tomar sua perspectiva formativa

Autopercepção negativa da audição e depressão em idosos: um estudo de base populacional

OBJECTIVE: To estimate the association between negative self-perception of hearing and depression in older adults in Southern Brazil. METHODS: This is a cross-sectional study conducted with data from the third wave of the EpiFloripa Idoso 2017/19 study, a population-based cohort of older adults (60+). A total of 1,335 older adults participated in this wave. The dependent variable was self-reported depression, and the main exposure was self-perception of hearing (negative; positive). For both the crude (bivariate) and adjusted analysis, the odds ratio (OR) was used as a measure of association and estimated by means of binary logistic regression analysis. The exposure variable was adjusted by sociodemographic and health covariates. A p value < 0.05 was adopted as statistically significant. RESULTS: The prevalence of negative self-perception of hearing and depression was 26.0% and 21.8%, respectively. In the adjusted analysis, the older adults with negative self-perception of hearing were 1.96 times more likely to report depression when compared to the ones with positive self-perception of hearing (p = 0.002). CONCLUSION: The association between negative self-perception of hearing and depression reflects the importance of reviewing health care actions for older adults, incorporating hearing-related issues, to ensure comprehensive care for this growing segment of the population.OBJETIVO: Estimar a associação entre a autopercepção negativa da audição e a depressão em idosos do sul do Brasil. MÉTODOS: Trata-se de um estudo transversal realizado com dados da terceira onda do estudo EpiFloripa Idoso 2017/19, de coorte de base populacional de idosos (60+). Participaram desta onda 1.335 idosos. A variável dependente foi a depressão autorreferida e a exposição principal foi a autopercepção auditiva (negativa; positiva). Tanto para a análise bruta (bivariada) quanto para a ajustada, a odds ratio (OR) foi utilizada como medida de associação e estimada por meio da análise de Regressão Logística Binária. A variável de exposição foi ajustada pelas covariáveis sociodemográficas e de saúde. Adotou-se o valor de p < 0,05 como estatisticamente significativo. RESULTADOS: A prevalência da autopercepção negativa da audição e depressão foi de 26,0% e 21,8%, respectivamente. Na análise ajustada, idosos com autopercepção negativa da audição apresentaram 1,96 vezes mais chance de referirem depressão quando comparados aos idosos com autopercepção positiva da audição (p = 0,002). CONCLUSÃO: A associação encontrada entre a autopercepção negativa auditiva e a depressão reflete a importância de rever as ações de atenção à saúde do idoso, incorporando questões relacionadas à audição para a garantia da atenção integral a esta parcela crescente da população

Estudo morfológico do xerogel híbrido dabco/sílica

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Transforming growth factor-beta family members are regulated during induced luteolysis in cattle

The transforming growth factors beta (TGFβ) are local factors produced by ovarian cells which, after binding to their receptors, regulate follicular deviation and ovulation. However, their regulation and function during corpus luteum (CL) regression has been poorly investigated. The present study evaluated the mRNA regulation of some TGFβ family ligands and their receptors in the bovine CL during induced luteolysis in vivo. On day 10 of the estrous cycle, cows received an injection of prostaglandin F2α (PGF) and luteal samples were obtained from separate groups of cows (n= 4-5 cows per time-point) at 0, 2, 12, 24 or 48 h after treatment. Since TGF beta family comprises more than 30 ligands, we focused in some candidates genes such as activin receptors (ACVR-1A, -1B, -2A, -2B) AMH, AMHR2, BMPs (BMP-1, -2, -3, -4, -6 and -7), BMP receptors (BMPR 1A, -1B and -2), inhibin subunits (INH-A, -BA, -BB) and betaglycan (TGFBR3). The mRNA levels of BMP4, BMP6 and INHBA were higher at 2 h after PGF administration (P<0.05) in comparison to 0 h. The relative mRNA abundance of BMP1, BMP2, BMP3, BMP4, BMP6, ACVR1B, INHBA and INHBB was upregulated up to 12 h post PGF (P<0.05). On the other hand, TGFBR3 mRNA that codes for a reservoir of ligands that bind to TGF-beta receptors, was lower at 48 h. In conclusion, findings from this study demonstrated that genes encoding several TGFβ family members are expressed in a time-specific manner after PGF administration

Functional Comparison of Induced Pluripotent Stem Cell- and Blood-Derived GPIIbIIIa Deficient Platelets

Human induced pluripotent stem cells (hiPSCs) represent a versatile tool to model genetic diseases and are a potential source for cell transfusion therapies. However, it remains elusive to which extent patient-specific hiPSC-derived cells functionally resemble their native counterparts. Here, we generated a hiPSC model of the primary platelet disease Glanzmann thrombasthenia (GT), characterized by dysfunction of the integrin receptor GPIIbIIIa, and compared side-by-side healthy and diseased hiPSC-derived platelets with peripheral blood platelets. Both GT-hiPSC-derived platelets and their peripheral blood equivalents showed absence of membrane expression of GPIIbIIIa, a reduction of PAC-1 binding, surface spreading and adherence to fibrinogen. We demonstrated that GT-hiPSC-derived platelets recapitulate molecular and functional aspects of the disease and show comparable behavior to their native counterparts encouraging the further use of hiPSC-based disease models as well as the transition towards a clinical application

The Stellar Content of Nearby Star-Forming Galaxies. III. Unravelling the Nature of the Diffuse Ultraviolet Light

We investigate the nature of the diffuse intra-cluster ultraviolet light seen in twelve local starburst galaxies, using long-slit ultraviolet spectroscopy obtained with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope (HST). We take this faint intra-cluster light to be the field in each galaxy, and compare its spectroscopic signature with STARBURST99 evolutionary synthesis models and with neighboring star clusters. Our main result is that the diffuse ultraviolet light in eleven of the twelve starbursts lacks the strong O-star wind features that are clearly visible in spectra of luminous clusters in the same galaxies. The difference in stellar features dominating cluster and field spectra indicate that the field light originates primarily from a different stellar population, and not from scattering of UV photons leaking out of the massive clusters. We consider several scenarios to understand the lack of observed O stars in the field, and their implications for the origin of the field stellar population. If the field stellar populations formed in situ, the field must either have an IMF which is steeper than Salpeter (3.0-3.5) or a Salpeter slope with an upper mass cutoff of 30-50 solar masses. If star formation occurs primarily in star clusters, the field could be composed of older, faded clusters, and/or a population which is coeval with the luminous clusters but lower in mass. If the field is composed of older, dissolving clusters, we estimate that star clusters (regardless of mass) need to dissolve on timescales 7-10 Myr to create the field (abridged).Comment: 25 pages, 6 figures, 7 tables; accepted, to appear ApJ 2005, vol. 62

Integrated safety analysis of filgotinib for ulcerative colitis: Results from SELECTION and SELECTIONLTE

BACKGROUND: Filgotinib 200 mg (FIL200) is an approved treatment for adults with moderately to severely active ulcerative colitis (UC). AIM: To report integrated safety data from the phase 2b/3 SELECTION study (NCT02914522) and its ongoing long-term extension study SELECTIONLTE (NCT02914535). METHODS: Safety outcomes were analysed in adults with moderately to severely active UC who received FIL200, filgotinib 100 mg (FIL100) or placebo once daily throughout the 11-week SELECTION induction study, the 47-week SELECTION maintenance study (if applicable) and SELECTIONLTE (if applicable). Exposure-adjusted incidence rates (EAIRs) per 100 censored patient-years of exposure with 95% confidence intervals were reported for treatment-emergent adverse events (AEs). Certain AE data were presented in subgroups, including age and prior biologic exposure status. RESULTS: This interim analysis included 1348 patients representing 3326.2 patient-years of exposure. Baseline characteristics of patients entering SELECTION were similar across treatment groups. EAIRs for serious infection, thromboembolic events and major adverse cardiovascular events (MACE) were consistently low across treatment groups. Most patients with MACE had cardiovascular risk factors. The EAIR for herpes zoster was numerically higher for FIL200 than for placebo. Infection incidences were numerically higher in biologic-experienced than biologic-naive patients. Higher incidences of certain AEs in patients 65 years of age or older were as expected. Four deaths occurred, including three cardiovascular deaths, none of which was considered related to filgotinib. CONCLUSION: FIL200 and FIL100 were well tolerated with no unexpected safety signals in patients with moderately to severely active UC, regardless of previous biologic exposure or age