Propuesta de mejoramiento a la gestión del clima organizacional con base en los resultados de la evaluación de desempeño de Veolia Colombia.

El proyecto de investigación tiene como objetivo principal proponer un plan de mejoramiento a la evaluación de desempeño implementada actualmente en la empresa Veolia Holding Colombia S.A, en la cual se han identificado una serie de matices que afectan el verdadero propósito de este proceso, repercutiendo principalmente en la motivación de los empleados, de esta manera pretendemos aportar significativamente al mejoramiento del clima laboral en la empresa. Según el análisis la empresa Veolia Holding Colombia S.A. tiene implementado una evaluación de desempeño realizada cada año, primero mediante autoevaluación y posterior a ello un formato de evaluación utilizado como herramienta para realizar sondeos mediante criterios por competencia y valores, lo que indicia que las relaciones laborales dentro de los trabajadores tiene un déficit y los trabajadores no califican este criterio de la mejor manera así mismo la iniciativa de toma de decisiones y el manejo de conflictos, lo que da como resultado del análisis que aunque este implementada esta herramienta no se trabaja en la empresa por una mejora de puntaje de estos ítems y tampoco de mejora del clima laboral. La propuesta sugerida a la empresa fue una implementación de una evaluación de desempeño 360 grados a todo el personal de la empresa, teniendo en cuenta los cuatro criterios de evaluación con el fin de ayudar a mejorar los estándares de evaluación de desempeño y así mismo poder mejorar las relaciones interpersonales en el ambiente de trabajo por medio de la adecuada implementación y manejo de esta herramienta tan importante en el área del talento humano.The main objective of the research project is to propose an improvement plan to the performance evaluation currently implemented in the company Veolia Holding Colombia SA, in which a series of nuances have been identified that affect the true purpose of this process, mainly affecting the motivation of the employees, in this way we intend to contribute significantly to the improvement of the work environment in the company. According to the analysis, the company Veolia Holding Colombia S.A. has implemented a performance evaluation carried out every year, first through self-evaluation and later an evaluation format used as a tool to carry out surveys using criteria by competence and values, which indicates that the labor relations within the workers have a deficit and the Workers do not qualify this criterion in the best way, as well as the decision-making initiative and conflict management, which results in the analysis that although this tool is implemented, the company does not work due to an improvement in the score of these items and neither does it improve the work environment. The proposal suggested to the company was an implementation of a 360-degree performance evaluation to all company personnel, taking into account the four evaluation criteria in order to help improve performance evaluation standards and also be able to improve interpersonal relationships in the work environment through the proper implementation and management of this very important tool in the area of human talent

Joint Observation of the Galactic Center with MAGIC and CTA-LST-1

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

Performance of the Large-Sized Telescope prototype of the Cherenkov Telescope Array

The next-generation ground-based gamma-ray Cherenkov Telescope Array Observatory (CTAO) will consist of imaging atmospheric Cherenkov telescopes (IACTs) of three different sizes distributed in two sites. The Large-Sized Telescopes will cover the low-energy end of the CTA energy range, starting at about 20 GeV. After its first years of operation at the CTA northern site, the Large-Sized Telescope prototype (LST-1) is in the final stage of its commissioning phase, having collected a significant amount of scientific data to date.In this contribution, we present the physics performance of the telescope using low-zenith Crab Nebula observations and Monte Carlo simulations fine-tuned accordingly. We show performance figures of merit such as the energy threshold, effective area, energy and angular resolution, and sensitivity based on the standard Hillas-parameters approach and following the source-independent and dependent analysis methods. The analysis threshold is estimated at 30 GeV. The energy resolution is around 30%, and the angular resolution is 0.3 degrees at 100 GeV.The best integral sensitivity of LST-1 is about 1.1% of the Crab Nebula flux above 250 GeV for 50 hours of observations. We also show the spectral energy distribution and light curve from Crab Nebula observations, which agree with results from other IACTs and link smoothly with Fermi-LAT when considering statistical and systematic uncertainties near the energy threshold

Study of Photon Strength Function of Actinides : the Case of U-235, Np-238 and Pu-241

The decay from excited levels in medium and heavy nuclei can be described in a statistical approach by means of Photon Strength Functions and Level Density distributions. The study of electromagnetic cascades following neutron capture based on the use of high efficiency detectors has been shown to be well suited for probing the properties of the Photon Strength Function of heavy (high level density) and/or radioactive (high background) nuclei. In this work we have investigated for the first time the validity of the recommended PSF of actinides, in particular U-235, Np-238 and Pu-241. Our study includes the search for resonance structures in the PSF below S-n and draws conclusions regarding their existence and their characteristics in terms of energy, width and electromagnetic nature.Peer reviewe

Neutron Capture Measurements on Minor Actinides at the n_TOF Facility at CERN : Past, Present and Future

The successful development of advanced nuclear systems for sustainable energy production and nuclear waste management depends on high quality nuclear data libraries. Recent sensitivity studies and reports [1-3] have identified the need for substantially improving the accuracy of neutron cross-section data for minor actinides. The n_TOF collaboration has initiated an ambitious experimental program for the measurement of neutron capture cross sections of minor actinides. Two experimental setups have been constructed for this purpose: a Total Absorption Calorimeter (TAC) [4] for measuring neutron capture cross-sections of low-mass and/or radioactive samples and a set of two low neutron sensitivity C(6)D(6) detectors for the less radioactive materials.Peer reviewe

Timing of Cholecystectomy After Moderate and Severe Acute Biliary Pancreatitis

IMPORTANCE Considering the lack of equipoise regarding the timing of cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP), it is critical to assess this issue.OBJECTIVE To assess the outcomes of early cholecystectomy (EC) in patients with moderately severe and severe ABP.DESIGN, SETTINGS, AND PARTICIPANTS This cohort study retrospectively analyzed real-life data from the MANCTRA-1 (Compliance With Evidence-Based Clinical Guidelines in the Management of Acute Biliary Pancreatitis) data set, assessing 5304 consecutive patients hospitalized between January 1, 2019, and December 31, 2020, for ABP from 42 countries. A total of 3696 patients who were hospitalized for ABP and underwent cholecystectomy were included in the analysis; of these, 1202 underwent EC, defined as a cholecystectomy performed within 14 days of admission. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality and morbidity. Data analysis was performed from January to February 2023.MAIN OUTCOMES Mortality and morbidity after EC.RESULTS Of the 3696 patients (mean [SD] age, 58.5 [17.8] years; 1907 [51.5%] female) included in the analysis, 1202 (32.5%) underwent EC and 2494 (67.5%) underwent delayed cholecystectomy (DC). Overall, EC presented an increased risk of postoperative mortality (1.4% vs 0.1%, P <.001) and morbidity (7.7% vs 3.7%, P < .001) compared with DC. On the multivariable analysis, moderately severe and severe ABP were associated with increased mortality (odds ratio [OR], 361.46; 95% CI, 2.28-57 212.31; P = .02) and morbidity (OR, 2.64; 95% CI, 1.35-5.19; P = .005). In patients with moderately severe and severe ABP (n = 108), EC was associated with an increased risk of mortality (16 [15.6%] vs 0 [0%], P < .001), morbidity (30 [30.3%] vs 57 [5.5%], P < .001), bile leakage (2 [2.4%] vs 4 [0.4%], P = .02), and infections (12 [14.6%] vs 4 [0.4%], P < .001) compared with patients with mild ABP who underwent EC. In patients with moderately severe and severe ABP (n = 108), EC was associated with higher mortality (16 [15.6%] vs 2 [1.2%], P < .001), morbidity (30 [30.3%] vs 17 [10.3%], P < .001), and infections (12 [14.6%] vs 2 [1.3%], P < .001) compared with patients with moderately severe and severe ABP who underwent DC. On the multivariable analysis, the patient's age (OR, 1.12; 95% CI, 1.02-1.36; P = .03) and American Society of Anesthesiologists score (OR, 5.91; 95% CI, 1.06-32.78; P = .04) were associated with mortality; severe complications of ABP were associated with increased mortality (OR, 50.04; 95% CI, 2.37-1058.01; P = .01) and morbidity (OR, 33.64; 95% CI, 3.19-354.73; P = .003).CONCLUSIONS AND RELEVANCE This cohort study's findings suggest that EC should be considered carefully in patients with moderately severe and severe ABP, as it was associated with increased postoperative mortality and morbidity. However, older and more fragile patients manifesting severe complications related to ABP should most likely not be considered for EC

Variability studies of active galactic nuclei from the long-term monitoring program with the Cherenkov Telescope Array

Blazars are active galactic nuclei (AGN) with a relativistic jet oriented toward the observer. This jet is composed of accelerated particles which can display emission over the entire electromagnetic spectrum. Spectral variability has been observed on short- and long-time scales in AGN, with a power spectral density (PSD) that can show a break at frequencies below the well-known red-noise process. This break frequency in the PSD has been observed in X-rays to scale with the accretion regime and the mass of the central black hole. It is expected that a break could also be seen in the very-high-energy gamma rays, but constraining the shape of the PSD in these wavelengths has not been possible with the current instruments. The Cherenkov Telescope Array (CTA) will be more sensitive by a factor of five to ten depending on energy than the current generation of imaging atmospheric Cherenkov telescopes, therefore it will be possible with CTA to reconstruct the PSD with a high accuracy, bringing new information about AGN variability. In this work, we focus on the AGN long-term monitoring program planned with CTA. The program is proposed to begin with early-start observing campaigns with CTA precursors. This would allow us to probe longer time scales on the AGN PSD