LETTER TO THE EDITOR: Toward overcoming the challenges facing biomedical analyses

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Dopaminergic System: Selected Advances and Emerging Potential Therapeutic Targets

Studies on different physiological and pathophysiological properties of the dopaminergic system have led to novel evidences and theories that suggest the possible targeting of such system in a variety of pathologies and disorders. Herein, we illustrate the applications and the therapeutic importance that such findings and advances might have. We hope that the content of this work will guide researches devoted to dopaminergic aspects that combine neurosciences with pharmacology

Tumors, Neurotransmitters and Pharmacology: Interactions and Implications

Tumors represent a challenge for the modern therapies, and divers studies have shown that different factors are involved in both tumorigenesis and processes of tumor development. Therefore, further investigations and descriptions of inter-influences and interactions between the nervous system, the tumoral process and pharmacotherapies might lead to novel advances and applications, not only in the therapeutical approaches but also in the experimental design

New factors influencing G protein coupled receptors’ system functions

New factors such as the G protein coupled receptor (GPCR) surrounding’s chemical environment, cell membrane constituents, the existent gap junction, endogenous receptor affinity status and animal species have been shown to influence the GPCR physiology and variations of those factors can modify the functions of the GPCRs, thus highlighting the possibility to exploit these properties in different pharmacological fields which may lead to obtaining new therapeutic methods and applications. Furthermore, it might help in developing new research methods.Keywords: G protein coupled receptor; Pharmacodynamics facto

Effects of different cooking methods on minerals, vitamins and nutritional quality indices of grass carp (Ctenopharyngodon idella)

This study aimed to evaluate the nutritional value (proximate composition, fatty acid profiles, vitamins and minerals) contents and also nutritional quality indices (NQI)) of grass carp (Ctenopharyngodon idella) prepared according to common consumer techniques: raw, poached, steamed, microwaved, pan-fried and deep-fried (in olive oil). In comparison to raw fish fillets, when grass carp was cooked there was an increase in protein, lipid and ash contents. Cooking methods had no significant effect on total n-3 fatty acids except for frying fillets. Lowest and highest content of n-3 was shown in deep-fried and pan-fried samples, respectively. Total n-6 fatty acid of cooked samples increased in comparison to raw samples. Na, K, Mg, P and Zn contents of boiled fish fillets significantly decreased. None of cooking methods had a significant effect a vitamin D. However, vitamin A, B_1 and B_3 contents of cooked fish significantly decreased

Extraction and neutralization nematocyst venom of Crambionella orsini jellyfish [whit] using of chelating Na-EDTA

Jellyfish is one of the poisonous animals that causing human poisoning. Found a variety of jellyfish in the Persian Gulf. Although these species can't Cause of quick death in humans but they have harmful effects on human health system and have Following are the side effects. In this study extracted Crambionella Orsini Jellyfish Venom According to Bloom method and was obtained its Concentration by Biuret method and Calculated LD50 by Jung and Choi method. According to Venom concentration and its LD50 was determined that Cause of death mice 0.5 ml of venom. The use of Na-EDTA for neutralizing venom. This Chelate Was injected in two ways to mice that in both methods, Prevented death. Na-EDTA is dedicated Chelate for Calcium excretion from body that According to nuclear calcium's venom is able to separated that from Venom structure and neutralize venom

The effect of changes in temperature on the toxicity of jellyfish, Crambionella orsini

The aim of this study was to evaluate the effect of temperature changes to reduce toxicity of jellyfish Crambionellaorsini venom. Venom extraction was done according to Bloom method. Sonication was used to break the wall of nematocysts capsule and then the resulting solution was centrifuged. To evaluate the effect of temperature on the venom, it was heated at different temperatures and then injected into sori mice. After catching jellyfish, Crambionellaorsini from Arvand stream estuary edges of umbrellas and tentacles of jellyfish were separated and kept in water LD_50 of toxins were calculated by Jung and Choi method and statistical analysis to obtain minimal lethal dose of poison done by Excel 2007. The results showed that the venom of jellyfish Crambionellaorsini, like venom of other animals is, based on a protein and that is sensitive to heat. This venom is disabled and lose their structure at 48 °C and its minimum lethal dose is 0.5 ml

Morphological and molecular identification of brown algae, Padina sp. in Lengeh Port, Persian Gulf

Brown algae, Padina sp., are found across tropical coastal areas as well as inter-tidal and sub-tidal regions. The aim of this research was to identify the morphological and molecular characteristics of the Padina species distributed across Port Lengeh in the Persian Gulf using morphological examinations and rbcL chloroplast gene sequencing. For this purpose, morphological features were undertaken using valid identification keys. For the molecular analysis, genomic DNA was extracted through slightly modified CTAB. The amplification of fragments was carried out using rbcL primers. The analysis of genome sequences was undertaken using Chromas, BioEdit and MEGA6 and the phylogenetic trees were constructed through Neighbor Joining (NJ) and Maximum Likelihood (ML). The results indicated that there was a 99% chance that the two identified Padina species (P. boergessenii and P. australis) belonged to the same cluster and that there were large genetic similarities among the compared Padina species registered in GenBank

Monoaminergic and histaminergic strategies and treatments in brain diseases

The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems. Later, some dramatic side effects associated with older medicines were shown to disappear with new chemical compounds targeting the origin of the therapeutic benefit more specifically. The increased knowledge regarding the function and interaction of the monoaminergic systems in the brain resulting from in vivo neurochemical and neurophysiological studies indicated new monoaminergic targets that could achieve the efficacy of the older medicines with fewer side-effects. Yet, this accumulated knowledge regarding monoamines did not produce valuable strategies for diseases where no monoaminergic drug has been shown to be effective. Here, we emphasize the new therapeutic and monoaminergic-based strategies for the treatment of psychiatric diseases. We will consider three main groups of diseases, based on the evidence of monoamines involvement (schizophrenia, depression, obesity), the identification of monoamines in the diseases processes (Parkinson's disease, addiction) and the prospect of the involvement of monoaminergic mechanisms (epilepsy, Alzheimer's disease, stroke). In most cases, the clinically available monoaminergic drugs induce widespread modifications of amine tone or excitability through neurobiological networks and exemplify the overlap between therapeutic approaches to psychiatric and neurological conditions. More recent developments that have resulted in improved drug specificity and responses will be discussed in this review.peer-reviewe