Screening of Synergic Interactions of Anti-Angiogenic and Anti-Tumor Compounds

Solid cancers have several common characteristics that Hanahan & Weinberg named as the hallmarks of cancer. Angiogenesis is an essential hallmark of cancer because tumor cells need oxygen and nutrients delivered by the vascular system. In fact, tumor growth and metastasis are angiogenesis dependent, and microvascular endothelial cells recruited by tumors have become an important target in cancer therapy. Combinations of drugs with different modes of action may lead to enhanced antitumor and antiangiogenic effects without injuring the host. The combined use of two drugs may sometimes produce enhanced, unchanged or diminished effects in comparison with their individual effects. These three different types of behaviour of the interacting drugs are called synergy, additive/indifferent and antagonistic effects. In the present work, we analyze 105 paired combinations of 15 compounds, some described by our research group as potent antiangiogenic compounds, and others currently used in clinical therapy. Our results show synergistic effects of several paired combinations using the MTT assay. [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)].This communication has the support of a travel grant "Universidad de Málaga.Campus de Excelencia Internacional Andalucía Tech".Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Defining efficient policies in a general equilibrium model: a multi-objective approach

Macroeconomic policy makers are typically concerned with several indicators of economic performance. We thus propose to tackle the design of macroeconomic policy using Multicriteria Decision Making (MCDM) techniques. More specifically, we employ Multiobjective Programming (MP) to seek so-called efficient policies. The MP approach is combined with a computable general equilibrium (CGE) model. We chose use of a CGE model since they have the dual advantage of being consistent with standard economic theory while allowing one to measure the effect(s) of a specific policy with real data. Applying the proposed methodology to Spain (via the 1995 Social Accounting Matrix) we first quantified the trade-offs between two specific policy objectives: growth and inflation, when designing fiscal policy. We then constructed a frontier of efficient policies involving real growth and inflation. In doing so, we found that policy in 1995 Spain displayed some degree of inefficiency with respect to these two policy objectives. We then offer two sets of policy recommendations that, ostensibly, could have helped Spain at the time. The first deals with efficiency independent of the importance given to both growth and inflation by policy makers (we label this set: general policy recommendations). A second set depends on which policy objective is seen as more important by policy makers: increasing growth or controlling inflation (we label this one: objective-specific recommendations)

Analysis of ultra low cycle fatigue problems with the barcelona plastic damage model

This paper presents a plastic formulation based on the Barcelona plastic damage model ([1], [2]) capable of predicting the material failure due to Ultra Low Cycle Fatigue. This is achieved taking into account the fracture energy dissipated during the cyclic process. This approach allows the simulation of ULCF in regular cyclic tests, but also in non-regular cases such as seismic loads

Competencias básicas: un marco legislativo, teórico y aplicativo

El presente trabajo pretende realizar un recorrido por las principales directrices educativas españolas contemporáneas que más han influido en la mayor parte de los discentes españoles como son la Ley General de 1970, la Ley Orgánica General del Sistema Educativo o LOGSE, la malograda Ley de Calidad Educativa o LOCE y la actual Ley Orgánica de Educación o LOE hasta llegar a la progresiva implantación de las Competencias Básicas, recopilando en las mismas las diversas aportaciones legales mencionadas, asumiendo el marco teórico interno _legal_ y externo _directrices europeas_ y proponiendo someramente un marco de aplicación en el aula respecto a su desarrollo, implantación y evaluación, desde corrientes pedagógicas liberadoras y humanísticas como la concientización de Freire, el currículo praxiológico, y, más modernamente el Informe Delors sobre la Educación de 1996 de la UNESCO.The present work a tour tries to realize for the principal contemporary educational Spanish directives who more have influenced most of the Spanish pupils since are the General Law of 1970, the Organic General Law of the Educational System or LOGSE, the unsuccessful Law of Educational Quality or LOCE and the current Organic Law of Education or LOE up to coming to the progressive implantation of the Basic Competitions, compiling in the same diverse legal mentioned contributions, assuming the theoretical internal frame _legal_ and day pupil _European laws_ and proposing like a frame of application in the classroom with regard to his development, implantation and evaluation, from liberating and humanistic pedagogic currents as Freire’s concientizacion, the praxiological curricula, and nowadays the 1996 UNESCO Delor´s Inform about education.peerReviewe

Enfermedades tiroideas en équidos

La glándula tiroides juega un papel fundamental en muchas funciones del organismo, como por ejemplo en el crecimiento, en la maduración tisular y en el metabolismo. La función primaria de la glándula tiroides es la síntesis y liberación de triyodotironina (T3) y tiroxina (T4), las cuales están influenciadas por el efecto de la hormona estimulante de la glándula tiroides (TSH) y la hormona liberadora de tirotropina (TRH). A pesar de que las patologías de la glándula tiroides son poco frecuentes en caballos, entre los trastornos de la glándula tiroides que se pueden encontrar están el hipotiroidismo (más común en neonatos), el síndrome del enfermo eutiroideo, el hipertiroidismo y las neoplasias, siendo estas últimas la alteración más frecuente, sobre todo los tumores benignos tipo adenoma. El pronóstico de todas estas patologías no es grave y raramente conllevan la muerte del animal. No obstante, el diagnostico asertivo de estas afecciones requiere pruebas específicas tales como la determinación de las concentraciones séricas de hormonas tiroideas junto con la realización de pruebas funcionales o dinámicas, ya que si sólo se lleva a cabo una medición puntual de hormonas tiroideas se puede incurrir en falsos diagnósticos. Igualmente, en algunos casos es de ayuda la realización de una ecografía y/o biopsia de la glándula.Thyroid glands are essential for several organic functions such as growth, neural tissue maturation and metabolism. Thyroxine (T4) and triiodothyronine (T3) are the main hormones produced by thyroid glands, under regulation via feed-back from the pituitary gland (Thyroid stimulating hormone –TSH-) and hypothalamus (Thyrotropin-releasing hormone –TRH-). In horses, thyroid gland pathology is a rare, non-fatal finding with a good prognosis. Hypothyroidism (commonly in foals), euthyroid sick syndrome, hyperthyroidism and thyroid neoplasia can be found in equine patients with certain frequency. The most common thyroid pathology is neoplasia, being usually a benign adenoma. Diagnosis can be changeling in these pathologies and requires specific serum hormone determinations together with dynamic tests, since a punctual thyroid hormone measurement can provoke wrong conclusions and lead to misdiagnosis

Relación entre la resiliencia personal y las estrategias de afrontamiento en estudiantes

El propósito de esta investigación fue averiguar qué estrategias de afrontamiento eran las que utilizaban aquellos alumnos más resilientes personalmente, o dicho en otras palabras, qué estrategias de afrontamiento usaban aquellos estudiantes que eran más eficaces a la hora de manejar y superar situaciones estresantes producidas en su vida cotidiana. Se realizó un estudio descriptivo mediante encuesta. Participaron 620 estudiantes, 334 alumnos de bachillerato y 286 estudiantes universitarios, el 50% mujeres. Cumplimentaron dos instrumentos de medida: una escala de Resiliencia y el cuestionario COPE-28 de Estrategias de Afrontamiento. A la vista de los resultados, existe relación positiva entre la Resiliencia Personal y las estrategias de afrontamiento Planificación, Afrontamiento Activo, Apoyo Instrumental, Humor, Reinterpretación Positiva y Aceptación. En cambio, existe relación negativa entre la Resiliencia Personal y Desconexión Conductual. Concluimos que los alumnos más resilientes personalmente utilizan en mayor medida el Afrontamiento Activo, Planificación, Apoyo Instrumental, Humor, Reinterpretación Positiva y Aceptación. En cambio, utilizan menos la Desconexión Conductual como estrategia de afrontamiento para superar situaciones críticas de estrés.Aim: The aim in this study was to find the relationship between Personal Resilience and Coping Strategies. Methodology: Descriptive study through inquiry. 620 students which 334 were high school degree students and 286 university students; 50 % of them were women. Two questionnaires were completed: one about Resilience and other about Coping Strategies COPE-28. Results: In one hand, there are positive correlation between Personal Resilience and Active Coping, Planning, Instrumental Support, Humor, Positive Reframing and Acceptance. In other hand, there are negative correlation between Personal Resilience and Behavioral Disengagement. In conclusion, the most significant findings show that the resilient students use more Active Coping, Planning, Instrumental Support, Humor, Positive Reframing and Acceptance. The less resilient studens use more Behavioral Disengagement.peerReviewe

A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana

Because of their sessile nature, plants have adopted varied strategies for growing and reproducing in an ever-changing environment. Control of mRNA levels and pre-mRNA alternative splicing are key regulatory layers that contribute to adjust and synchronize plant growth and development with environmental changes. Transcription and alternative splicing are thought to be tightly linked and coordinated, at least in part, through a network of transcriptional and splicing regulatory factors that interact with the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II. One of the proteins that has been shown to play such a role in yeast and mammals is pre-mRNA-PROCESSING PROTEIN 40 (PRP40, also known as CA150, or TCERG1). In plants, members of the PRP40 family have been identified and shown to interact with the CTD of RNA Pol II, but their biological functions remain unknown. Here, we studied the role of AtPRP40C, in Arabidopsis thaliana growth, development and stress tolerance, as well as its impact on the global regulation of gene expression programs. We found that the prp40c knockout mutants display a late-flowering phenotype under long day conditions, associated with minor alterations in red light signaling. An RNA-seq based transcriptome analysis revealed differentially expressed genes related to biotic stress responses and also differentially expressed as well as differentially spliced genes associated with abiotic stress responses. Indeed, the characterization of stress responses in prp40c mutants revealed an increased sensitivity to salt stress and an enhanced tolerance to Pseudomonas syringae pv. maculicola (Psm) infections. This constitutes the most thorough analysis of the transcriptome of a prp40 mutant in any organism, as well as the first characterization of the molecular and physiological roles of a member of the PRP40 protein family in plants. Our results suggest that PRP40C is an important factor linking the regulation of gene expression programs to the modulation of plant growth, development, and stress responses.Fil: Hernando, Carlos Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: García Hourquet, Mariano. Fundación Instituto Leloir; ArgentinaFil: de Leone, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Careno, Daniel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Iserte, Javier Alonso. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Mora Garcia, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

MooodvieWeb2: un sistema de persuasión conversacional para el recomendador MoodvieWeb

Tomando como base el recomendador MoodvieWeb nos encontramos con la necesidad de darle más dinamismo, de que se genere un verdadero diálogo entre el sistema y el usuario. Vemos necesario que el usuario participe de una manera más directa en el proceso de recomendación de películas, en este sentido se pretende que el sistema recoja el sentir del usuario, como se ajustan las películas recomendadas a él mismo. Un factor importante que no hemos querido olvidar en este diálogo es que todo el entorno sea más personal, más individualizado al usuario, para que se establezca con él un vínculo que le permita sentirse más cómodo y pueda confiar más en el sistema. También que presente la información necesaria para comprobar que las recomendaciones que se le ofrecen realmente son una buena opción. En conclusión se pretende que el usuario se encuentre con un sistema de recomendación versátil, con una interfaz atractiva, que le interpele directamente, que se ajuste en lo más posible a como es el usuario. En definitiva no solo que sea bueno sino que le genere al usuario la sensación de que es bueno, de que esta hecho pensando en él y sobre todo con el que pueda interactuar, y en el que la satisfacción del usuario sea una máxima. [ABSTRAC] Taking as a base the MoodvieWeb recommender, we can see the necessity of giving more dynamism, of generating a real dialogue between the user and the system. We consider important that the user participate in a more directly way in the process of movies recommendations, in this sense we want the system to collect the user’s feelings, and how the recommended movies adjust to himself. An important aspect that we have not wanted to forget in this dialogue is that the entire environment is more personal, more individualized to the user so that it is set with it a link it will feel more comfortable and can trust more in the system. Also, it shows the necessary information in order to check the offered recommendations are a really good choice. In conclusion, we expect that the user finds a versatile system of recommendations, with an attractive interface, that communicates him directly, which adapts as much as possible to user’s temperament. Finally not only having a good system but generating in the user the feeling of that is good, of that is made thinking on him and above all which can interact, and the user’s satisfaction is core idea

Improving argumentation-based recommender systems through context-adaptable selection criteria

Recommender Systems based on argumentation represent an important proposal where the recommendation is supported by qualitative information. In these systems, the role of the comparison criterion used to decide between competing arguments is paramount and the possibility of using the most appropriate for a given domain becomes a central issue; therefore, an argumentative recommender system that offers an interchangeable argument comparison criterion provides a significant ability that can be exploited by the user. However, in most of current recommender systems, the argument comparison criterion is either fixed, or codified within the arguments. In this work we propose a formalization of context-adaptable selection criteria that enhances the argumentative reasoning mechanism. Thus, we do not propose of a new type of recommender system; instead we present a mechanism that expand the capabilities of existing argumentation-based recommender systems. More precisely, our proposal is to provide a way of specifying how to select and use the most appropriate argument comparison criterion effecting the selection on the user´s preferences, giving the possibility of programming, by the use of conditional expressions, which argument preference criterion has to be used in each particular situation.Fil: Teze, Juan Carlos Lionel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; Argentina. Universidad Nacional de Entre Ríos; ArgentinaFil: Gottifredi, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; ArgentinaFil: García, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; ArgentinaFil: Simari, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; Argentin