100 research outputs found
Objective Measurement of the Visual Aspect of Dry Sausage Slices by Image Analysis
The visual aspect of food is a problem very often neglected for different reasons; one being the difficulty of modelling vision. However, it has been shown that , on simple synthetic images, automatic sorting in the same manner as human vision is possible.
Distribution heterogeneity of spots within an image is one important parameter for its characterization. A new algorithm was tested over simple numerical pictures that gave good agreement with visual appreciation. Images of twenty dry sausage slices were analyzed and different factors corresponding to aspect structure were calculated. Principal component analyst:s based on these factors all owed discrimination between the different types of sausage. The results obtained when studying the meat part of the slices were well correlated with the visual aspect
Fast interior point solution of quadratic programming problems arising from PDE-constrained optimization
Interior point methods provide an attractive class of approaches for solving linear, quadratic and nonlinear programming problems, due to their excellent efficiency and wide applicability. In this paper, we consider PDE-constrained optimization problems with bound constraints on the state and control variables, and their representation on the discrete level as quadratic programming problems. To tackle complex problems and achieve high accuracy in the solution, one is required to solve matrix systems of huge scale resulting from Newton iteration, and hence fast and robust methods for these systems are required. We present preconditioned iterative techniques for solving a number of these problems using Krylov subspace methods, considering in what circumstances one may predict rapid convergence of the solvers in theory, as well as the solutions observed from practical computations
On Block Triangular Preconditioners for the Interior Point Solution of PDE-Constrained Optimization Problems
We consider the numerical solution of saddle point systems of equations resulting from the discretization of PDE-constrained optimization problems, with additional bound constraints on the state and control variables, using an interior point method. In particular, we derive a Bramble-Pasciak Conjugate Gradient method and a tailored block triangular preconditioner which may be applied within it. Crucial to the usage of the preconditioner are carefully chosen approximations of the (1,1)-block and Schur complement of the saddle point system. To apply the inverse of the Schur complement approximation, which is computationally the most expensive part of the preconditioner, one may then utilize methods such as multigrid or domain decomposition to handle individual sub-blocks of the matrix system
Nuclear astrophysics: the unfinished quest for the origin of the elements
Half a century has passed since the foundation of nuclear astrophysics. Since
then, this discipline has reached its maturity. Today, nuclear astrophysics
constitutes a multidisciplinary crucible of knowledge that combines the
achievements in theoretical astrophysics, observational astronomy,
cosmochemistry and nuclear physics. New tools and developments have
revolutionized our understanding of the origin of the elements: supercomputers
have provided astrophysicists with the required computational capabilities to
study the evolution of stars in a multidimensional framework; the emergence of
high-energy astrophysics with space-borne observatories has opened new windows
to observe the Universe, from a novel panchromatic perspective; cosmochemists
have isolated tiny pieces of stardust embedded in primitive meteorites, giving
clues on the processes operating in stars as well as on the way matter
condenses to form solids; and nuclear physicists have measured reactions near
stellar energies, through the combined efforts using stable and radioactive ion
beam facilities. This review provides comprehensive insight into the nuclear
history of the Universe and related topics: starting from the Big Bang, when
the ashes from the primordial explosion were transformed to hydrogen, helium,
and few trace elements, to the rich variety of nucleosynthesis mechanisms and
sites in the Universe. Particular attention is paid to the hydrostatic
processes governing the evolution of low-mass stars, red giants and asymptotic
giant-branch stars, as well as to the explosive nucleosynthesis occurring in
core-collapse and thermonuclear supernovae, gamma-ray bursts, classical novae,
X-ray bursts, superbursts, and stellar mergers.Comment: Invited Review. Accepted for publication in "Reports on Progress in
Physics" (version with low-resolution figures
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract
Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a closed system with limited capability to repair or regenerate itself. Current evidence supports the view that cataractogenesis is a multifactorial process. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contribute to the development of eye lens opacity under conditions of diabetes. There is an urgent need for inexpensive, non-surgical approaches to the treatment of cataract. Recently, considerable attention has been devoted to the search for phytochemical therapeutics. Several pharmacological actions of natural flavonoids may operate in the prevention of cataract since flavonoids are capable of affecting multiple mechanisms or etiological factors responsible for the development of diabetic cataract. In the present paper, natural flavonoids are reviewed as potential agents that could reduce the risk of cataract formation via affecting multiple pathways pertinent to eye lens opacification. In addition, the bioavailability of flavonoids for the lens is considered
Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult
The endoneurial microenvironment, delimited by the endothelium of endoneurial vessels and a multi-layered ensheathing perineurium, is a specialized milieu intérieur within which axons, associated Schwann cells and other resident cells of peripheral nerves function. The endothelium and perineurium restricts as well as regulates exchange of material between the endoneurial microenvironment and the surrounding extracellular space and thus is more appropriately described as a blood–nerve interface (BNI) rather than a blood–nerve barrier (BNB). Input to and output from the endoneurial microenvironment occurs via blood–nerve exchange and convective endoneurial fluid flow driven by a proximo-distal hydrostatic pressure gradient. The independent regulation of the endothelial and perineurial components of the BNI during development, aging and in response to trauma is consistent with homeostatic regulation of the endoneurial microenvironment. Pathophysiological alterations of the endoneurium in experimental allergic neuritis (EAN), and diabetic and lead neuropathy are considered to be perturbations of endoneurial homeostasis. The interactions of Schwann cells, axons, macrophages, and mast cells via cell–cell and cell–matrix signaling regulate the permeability of this interface. A greater knowledge of the dynamic nature of tight junctions and the factors that induce and/or modulate these key elements of the BNI will increase our understanding of peripheral nerve disorders as well as stimulate the development of therapeutic strategies to treat these disorders
L'Italia come modello per l'Europa e per il mondo nelle politiche sanitarie per il trattamento dell'epatite cronica da HCV
The World Health Organization foresees the
elimination of HCV infection by 2030. In light of this and the curre
nt, nearly worldwide, restriction in direct-acting agents
(DAA) accessibility due to their high price, we aimed to evaluate
the cost-effectiveness of two alternative DAA treatment
policies: Policy 1 (universal): treat all patients, regardless of the fibrosis stage; Policy 2 (prioritized): treat only priori
tized
patients and delay treatment of the
remaining patients until reaching stage F3. T
he model was based on patient’s data
from the PITER cohort. We demonstrated that extending HC
V treatment of patients in any fibrosis stage improves health
outcomes and is cost-effective
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