186 research outputs found
Genetic variants and their interactions in disease risk prediction – machine learning and network perspectives
- Author
- 1000 Genomes Project
- A Ashworth
- A Burga
- A Califano
- A Galvan
- A Gyenesei
- A Statnikov
- A Torkamani
- A Torkamani
- AL Barabási
- AL Hopkins
- B Lehner
- B Lehner
- B Maher
- B Rakitsch
- BA McKinney
- BA McKinney
- BS Srinivasan
- C Ambroise
- C Kooperberg
- C Tian
- C Winter
- CG Lambert
- CS Greene
- D Merico
- D Urbach
- DJ Balding
- DM Evans
- DW Aha
- DW Huang
- DW Huang
- E Lee
- EA Ashley
- EE Eichler
- EE Schadt
- ES Lander
- F Barrenäs
- G Bebek
- G Gibson
- G Hannum
- G Peng
- GK Chen
- GM Clarke
- H Eleftherohorinou
- H Holm
- H Zhong
- HJ Cordell
- HY Chuang
- I Feldman
- I Guyon
- I König
- I Surakka
- J Corander
- J Jakobsdottir
- J Kruppa
- J Tuikkala
- J Yang
- JD Iglehart
- JH Moore
- JH Moore
- K Askland
- K Wang
- KA Pattin
- KS Reynolds
- L Luo
- M Ladouceur
- M Michaut
- M Mooney
- M Smoot
- M Vidal
- MA Heiskanen
- MD Ritchie
- MJ Sillanpää
- NA Lavender
- NF Marko
- O Lavi
- O Zuk
- P Beltrao
- P Donnelly
- P Kraft
- P Sebastiani
- P Smialowski
- PC Phillips
- PJ Castaldi
- Q He
- R Braun
- R Jelier
- R Makowsky
- R Simon
- RO Lindén
- S Lee
- S Okser
- S Ripatti
- S Varma
- SE Baranzini
- Sebastian Okser
- SJ Dixon
- SW Hartley
- T Hu
- T Ideker
- T Pahikkala
- T Peltola
- T Schupbach
- TA Manolio
- Tapio Pahikkala
- Tero Aittokallio
- TS Deisboeck
- TT Wu
- U Ober
- U Ober
- V Bansal
- VK Ramanan
- W Huang
- Wellcome Trust Case Control Consortium
- WG Kaelin Jr
- Y Saeys
- Z Wang
- Z Wei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Climate Change, Coral Reef Ecosystems, and Management Options for Marine Protected Areas
- Author
- A Bakun
- A Baldwin
- A Friedlander
- A Hastings
- A Shepherd
- AA Rosenberg
- AC Baker
- AE Douglas
- AL Perry
- AL Shanks
- Alan M. Friedlander
- B Cicin-Sain
- B Dickson
- B Michaelidis
- BI McNeil
- Billy D. Causey
- BJ Peterson
- BP Kinlan
- Brian D. Keller
- BS Halpern
- C Cabanes
- C Langdon
- C Mora
- C Wilkinson
- CB Munn
- CB Paris
- CD Harvell
- CD Harvell
- CDG Harley
- CG Soto
- CH Greene
- Christa M. Woodley
- CL Sabine
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CR Wilkinson
- CR Wilkinson
- CR Wilkinson
- CR Wilkinson
- D Harvell
- D Lirman
- D Pauly
- D Pauly
- D Scavia
- Daniel F. Gleason
- DB Snyder
- DE Burkepile
- DL Albritton
- DL Breitburg
- DM Baltz
- DR Bellwood
- DR Bellwood
- DR Bellwood
- DR Robertson
- DW Freshwater
- E McLeod
- E Rignot
- ED McCoy
- EE Sotka
- EF Pane
- Elizabeth McLeod
- EN Edinger
- ET Game
- F Micheli
- GA Burton Jr
- GE Davis
- GM Ruiz
- GP Jones
- GP Jones
- GR Walther
- GW Allison
- GW Allison
- H Galbraith
- HK Lotze
- HV Boyett
- HV McGregor
- I Mosquera
- I Nagelkerken
- J Engel
- JA Bohnsack
- JA Estes
- JA Kleypas
- JA Kleypas
- JA McGowan
- JA Sobel
- JBC Jackson
- JC Ogden
- JC Orr
- JE Johnson
- JF Bruno
- JG Hiddink
- JK Reaser
- JL Chen
- JM Coe
- JM Pandolfi
- JM Pandolfi
- JM Roberts
- JM Roessig
- JM West
- Johanna E. Johnson
- JP Barry
- JP McCarty
- JT Carlton
- JT Carlton
- JT Tilmant
- JW McManus
- JW Porter
- JW Porter
- K Caldeira
- K Engie
- K Kim
- KD Hyrenbach
- KE Fabricius
- KH Mann
- KK Yates
- KP Boessenkool
- KRT Whelan
- KT Frank
- L Burke
- L Burke
- L Cho
- L Fernandes
- L Kaufman
- LB Crowder
- LB Crowder
- LD Mydlarz
- LH Gunderson
- LR Gerber
- LS Mills
- M Beger
- M Khamer
- M Nyström
- M Ruckelshaus
- MA Hixon
- MA Snyder
- MD Behrens
- ME Kimball
- MH Carr
- MH Ledlie
- MJ Kaiser
- MJ McPhaden
- MP Lesser
- MP Marchetti
- MV Moore
- NAJ Graham
- National Marine Fisheries Service (NMFS)
- National Research Council (NRC)
- NJ Mantua
- NK Dulvy
- NL Bindoff
- NN Rabalais
- NRC
- O Hoegh-Guldberg
- O Hoegh-Guldberg
- O Hoegh-Guldberg
- P Hallock
- P Marshall
- P Marshall
- PA Fields
- PAR Hockey
- PB Moyle
- PE Whitfield
- Pew Oceans Commission (POC)
- PF Sale
- PJ Mumby
- PJ Mumby
- PK Dayton
- R Berkelmans
- R Condrey
- R Curry
- R Curry
- R Law
- RA Feely
- RB Aronson
- RE Bell
- Rikki Grober-Dunsmore
- RJ Nicholls
- RJ Orth
- RJT Klein
- RK Cowen
- RK Cowen
- Robert S. Steneck
- RR Stewart
- RR Warner
- RS Steneck
- RS Steneck
- RS Steneck
- RS Steneck
- RV Salm
- RW Grigg
- S Airamé
- S Philip
- S Wells
- SA Levin
- SA Murawski
- Satie Airamé
- SD Donner
- SD Donner
- SE Edge
- SE Edge
- SE Swearer
- SF Thrush
- SJ McNaughton
- SR Carpenter
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Thorrold
- Steven L. Miller
- SV Smith
- T Done
- TA Gardner
- TA Gardner
- The Royal Society (TRS)
- TJ Done
- TP Hughes
- TP Hughes
- TR McClanahan
- US Department of Commerce (USDOC)
- WF Precht
- WK Fitt
- WP Sousa
- Y Sadovy
- Y Shirayama
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Marine protected areas (MPAs) provide place-based management of marine ecosystems through various degrees and types of protective actions. Habitats such as coral reefs are especially susceptible to degradation resulting from climate change, as evidenced by mass bleaching events over the past two decades. Marine ecosystems are being altered by direct effects of climate change including ocean warming, ocean acidification, rising sea level, changing circulation patterns, increasing severity of storms, and changing freshwater influxes. As impacts of climate change strengthen they may exacerbate effects of existing stressors and require new or modified management approaches; MPA networks are generally accepted as an improvement over individual MPAs to address multiple threats to the marine environment. While MPA networks are considered a potentially effective management approach for conserving marine biodiversity, they should be established in conjunction with other management strategies, such as fisheries regulations and reductions of nutrients and other forms of land-based pollution. Information about interactions between climate change and more “traditional” stressors is limited. MPA managers are faced with high levels of uncertainty about likely outcomes of management actions because climate change impacts have strong interactions with existing stressors, such as land-based sources of pollution, overfishing and destructive fishing practices, invasive species, and diseases. Management options include ameliorating existing stressors, protecting potentially resilient areas, developing networks of MPAs, and integrating climate change into MPA planning, management, and evaluation
Racism as a determinant of health: a systematic review and meta-analysis
- Author
- A Borders
- A Chakraborty
- A Harris-Britt
- A Kaduvettoor-Davidson
- A Lewin
- A Llacer
- A Markus
- A Sharma
- A Soylu
- A Thomas
- A-M Vremăroiu
- AA Agudelo-Suarez
- AB de Castro
- AC Crouter
- AD Howarter
- AD Ong
- AGTT Tran
- AI Padela
- AJ Umaña-Taylor
- AL Burrow
- AL Pieterse
- AL Pieterse
- AL Pieterse
- AL Pieterse
- Alex Pieterse
- AM Cislo
- Amanuel Elias
- AMC Lam
- AO Behnke
- AO Berg
- AR Fischer
- Arpana Gupta
- AS Mak
- AT Chakraborty
- B Dixon
- B Major
- B Moradi
- B Moradi
- B Moradi
- B Oppedal
- B Oppedal
- B Trevino
- BA Dawson
- BB Reeve
- BC Thoma
- BD Stucky
- BE Armenta
- BK Finch
- BM Tynes
- C Berkel
- C Cassidy
- C Cassidy
- C Deblaere
- C Giurgescu
- C Hamilton
- C Larson
- C Lay
- C Logie
- C Rousseau
- CA Rees
- CA Reisen
- CB Roberts
- CD Cogburn
- CL Broman
- CL Currie
- CM Dolezsar
- CM Loo
- CP Harrell
- CR Lyles
- CR Lyles
- D Chae
- D Chrobot-Mason
- D English
- D Heim
- D Low
- D Mayrl
- D Moher
- D Rivas-Drake
- D Silove
- D Stevens-Watkins
- DC Cooper
- DD Matthews
- DH Chae
- DH Chae
- DJ Barksdale
- DJ Burgess
- DL DuBois
- DL Lee
- DL Lee
- DL Lee
- DM Szymanski
- DR Byrd
- DR Combs
- DR Williams
- DR Williams
- DR Williams
- DR Williams
- DR Williams
- DR Williams
- DR Williams
- DT Barry
- E Brondolo
- E Brondolo
- E Brondolo
- E Brondolo
- E Flores
- E Flores
- E Polek
- E Tartakovsky
- E Tartakovsky
- E Wadsworth
- E Yoon
- E. Brondolo
- EA Klonoff
- EA Pascoe
- EC Chambers
- EC Odom
- EI Lorenzo-Blanco
- EK Pavalko
- EK Seaton
- EK Shrake
- ER Grekin
- ES Jenifer
- ES Tull
- ES Tull
- ES Tull
- EW Neblett Jr.
- EWJ Neblett
- F Mansouri
- F Neto
- F Neto
- F Neto
- FG De Maio
- FI Soriano
- FM Jackson
- FM Moghaddam
- FX Gibbons
- FX Gibbons
- FX Gibbons
- G Berman
- G Borges
- G Gee
- G Kim
- GC Gee
- GC Gee
- GC Gee
- GC Gee
- GH Bodkin-Andrews
- GH Brody
- Gilbert Gee
- GJ Wagner
- GL Stein
- GM Moore-Greene
- GS Mesche
- GWJM Stevens
- H Landrine
- H-J Chen
- H-W Revollo
- HC Yoo
- HC Yoo
- HD Conklin
- HER Hunte
- HL Jones
- HM Cooper
- HM Prelow
- HM Prelow
- HS Shorey
- HS Thompson
- I Jasinskaja-Lahti
- I Jasinskaja-Lahti
- I Jasinskaja-Lahti
- IH Kim
- IJ Ornelas
- ILG Todorova
- J Blankenau
- J Cohen
- J Kaholokula
- J Schaafsma
- J Schnittker
- J Tawa
- J Taylor
- J Taylor
- J Vasquez
- J Wagner
- JB Goto
- JE Helms
- Jehonathan Ben
- JF Brown
- JK Asamen
- JL Bastos
- JL Raver
- JP Shonkoff
- JS Jackson
- JS Phinney
- K Liebkind
- K Sanders-Phillips
- K Siefert
- K-H Choi
- KA Yoder
- KF Jackson
- KH Banks
- KH Zeiders
- KL Hansen
- KM Rospenda
- KR Ford
- KT Chana
- KT Schneider
- L Ashburn-Nardo
- L Ayalon
- L Becares
- L Hedges
- L Omma
- L Torres
- L Torres
- L Torres
- L Torres
- LA Szalacha
- LB Hightow-Weidman
- LB Whitbeck
- LK Hill
- LM Bogart
- LM Jamieson
- LM Pachter
- LN Borrell
- LN Borrell
- LP Juang
- LP Juang
- LP Sheridan
- LRM Hausmann
- LRM Hausmann
- LS Giamo
- LS Rucker
- LS Rucker
- M Berger
- M Borenstein
- M Egger
- M Gerrard
- M Han
- M Jasperse
- M Semyonov
- M Verkuyten
- M Verkuyten
- M Verkuyten
- M Wei
- M Wei
- M Wei
- M Wei
- MA Albert
- MA Pointer
- Margaret Kelaher
- MC Rosas
- MD McNeilly
- ME Barrett
- ME Peek
- ME Roberts
- MJ Martin
- ML Greene
- ML Halim
- MR Benjamins
- MR Benjamins
- MR Benjamins
- MS Downie
- MS Himmelstein
- MT Hicken
- MT Hicken
- MT Schmitt
- MT Schmitt
- MY Delgado
- N Copeland-Linder
- N Eisenberger
- N Krieger
- N Krieger
- N Krieger
- N Krieger
- N Krieger
- N Krieger
- N Krieger
- N Mulia
- N Pole
- N Priest
- N Priest
- N Priest
- NA Bowman
- Naomi Priest
- NC Priest
- Nida Denson
- NJ Everage
- NR Branscombe
- NT Buchanan
- OB Epel
- P Tummala-Narra
- Palacio SP Piedrahita
- PR Smokowski
- PR Smokowski
- PR Smokowski
- PR Steffen
- PR Steffen
- PW Barnes
- Q-L Huynh
- R Broudy
- R Cardarelli
- R Clark
- R Clark
- R Clark
- R Clark
- R Clark
- R Clark
- R Clark
- R Clement
- R Fu
- R Rosenthal
- RA Donovan
- RJ Contrada
- RL Simons
- RL Simons
- RM Baron
- RM Blank
- RM Diaz
- RM Lee
- RM Lee
- RM Peters
- RM Peters
- RM Sellers
- RM Sellers
- RM Sellers
- Robert K Hills
- S Abdulrahim
- S Crengle
- S Duval
- S Duval
- S Freedenthal
- S Kulis
- S McNeil
- S Shariff-Marco
- S Shariff-Marco
- S Szanton
- SB Wyatt
- SCY Yap
- SE French
- SE Gutierres
- SF Lambert
- SG Alamilla
- SG Cakir
- SK Carlisle
- SL Sellers
- SM Quintana
- SO Utsey
- SO Utsey
- SR Ahmed
- ST Bird
- SW Pan
- T Postmes
- TA LaVeist
- TA Mahonen
- TJ Cronin
- TJ Cunningham
- TJ Cunningham
- TKA Wickrama
- TL Bowen-Reid
- TN Brown
- TP Dominguez
- TP LeBel
- TR Coker
- TT Lewis
- TT Lewis
- TT Lewis
- V Santana
- V Swami
- VM Murry
- VM Murry
- VM Nyborg
- VN Salgado de Synder
- VR Clark
- VW Huynh
- WP Hammond
- WS Poston
- Y Paradies
- Y Paradies
- Y Paradies
- Y Shigemoto
- Yin Paradies
- YL Cuffee
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Despite a growing body of epidemiological evidence in recent years documenting the health impacts of racism, the cumulative evidence base has yet to be synthesized in a comprehensive meta-analysis focused specifically on racism as a determinant of health. This meta-analysis reviewed the literature focusing on the relationship between reported racism and mental and physical health outcomes. Data from 293 studies reported in 333 articles published between 1983 and 2013, and conducted predominately in the U.S., were analysed using random effects models and mean weighted effect sizes. Racism was associated with poorer mental health (negative mental health: r = -.23, 95% CI [-.24,-.21], k = 227; positive mental health: r = -.13, 95% CI [-.16,-.10], k = 113), including depression, anxiety, psychological stress and various other outcomes. Racism was also associated with poorer general health (r = -.13 (95% CI [-.18,-.09], k = 30), and poorer physical health (r = -.09, 95% CI [-.12,-.06], k = 50). Moderation effects were found for some outcomes with regard to study and exposure characteristics. Effect sizes of racism on mental health were stronger in cross-sectional compared with longitudinal data and in non-representative samples compared with representative samples. Age, sex, birthplace and education level did not moderate the effects of racism on health. Ethnicity significantly moderated the effect of racism on negative mental health and physical health: the association between racism and negative mental health was significantly stronger for Asian American and Latino(a) American participants compared with African American participants, and the association between racism and physical health was significantly stronger for Latino(a) American participants compared with African American participants.<br /
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
- Author
- A Bal-Price
- A Barth
- A Brand
- A Cargnoni
- A Ekonomou
- A Ekonomou
- A Haberg
- A Huber
- A Klishin
- A Melani
- A Mendonça de
- A Mendonça de
- A Mendonça de
- A Mendonça de
- A Monopoli
- A Monopoli
- A Mori
- A Nishi
- A Ohta
- A Petroni
- A Pinna
- A Pintor
- A Pintor
- A Richter
- A Ruiz
- A Wieraszko
- A Wieraszko
- AA Link
- AB Blood
- AC Newby
- AC Ngai
- AI Jimenez
- AM Coney
- AM Sebastião
- AM Sebastião
- AM Sebastião
- AM Sebastião
- AR Costenla
- AR Costenla
- B Johansson
- B Johansson
- B Liu
- B Sperlagh
- BA Walker
- BB Fredholm
- BB Fredholm
- BB Fredholm
- BB Fredholm
- BD Hettinger
- BD Hettinger
- BL Fiebich
- BL Fiebich
- BM Küst
- C Brodie
- C Corsi
- C Corsi
- C Corsi
- C Corsi
- C Hammarberg
- C Psarropoulou
- C Volonté
- CA Barnes
- CD Bonan
- CD Sturm
- CE Stout
- CJ Hunter
- CM Anderson
- CP Turner
- CP Turner
- CP Turner
- CR Lupica
- CU Kloss
- D Blum
- D Blum
- D Cunha-Reis
- D Lobner
- D Lobner
- D Quarta
- D Vendite
- D Young
- DA Rusakov
- DC Cassada
- DC Cassada
- DJ Doolette
- DJ Mogul
- DJ Rossi
- DK Lubitz von
- DK Lubitz Von
- DK Nguyen
- DR Seo
- E Angulo
- E Bona
- E Hosli
- E Lewin
- E Panther
- EA Newman
- ES Rosenzweig
- ES Vizi
- F Angelatou
- F Calon
- F Ciruela
- F Ciruela
- F Pedata
- FE Parkinson
- FE Parkinson
- FF Youssef
- FS Lee
- FU Fontella
- G Arcuino
- G Arslan
- G Cai
- G Hasko
- G Hasko
- G Pinhal-Enfield
- G Queiróz
- G Zhang
- GJ Liu
- GM Khan
- GR Phillips
- GW Kreutzberg
- GW Sullivan
- H Higashi
- H Kase
- H Kato
- H Li
- H Nagasawa
- H Neuman
- H Onodera
- H Zimmermann
- H Zimmermann
- HK Lee
- HL Maddock
- I Allaman
- I Mody
- J Barankiewicz
- J Deckert
- J Deckert
- J Deckert
- J Fastbom
- J Hammer
- J Hardy
- J Kipnis
- J Kipnis
- J Ulas
- JA McPherson
- JB Wiesner
- JC Fowler
- JC Shryock
- JD Geiger
- JE Nash
- JF Chen
- JF Chen
- JF Chen
- JF Doriat
- JF Doriat
- JG Pilitsis
- JJ Lynch
- JL Daval
- JM Brundege
- JM Ferreira
- JM Gidday
- JM Zhang
- JN Halle
- JP Headrick
- JP Wetherington
- JS Fink
- JT Cheng
- JW Phillis
- JW Phillis
- JW Phillis
- JW Phillis
- JW Phillis
- K Biber
- K Biber
- K Bshesh
- K Ikeda
- K Ishiwata
- K Obrietan
- K Varani
- K Wirkner
- K Xu
- K Yasui
- K Yoshioka
- KA Jacobson
- KA Moore
- KA Rudolphi
- KP Scholz
- KS Lee
- L Gimenez-Llort
- L Giovannelli
- L Oliveira
- LA Bauman
- LP Miller
- LV Lopes
- LV Lopes
- LV Lopes
- LV Lopes
- LV Lopes
- M Adami
- M Canals
- M Canals
- M Diáz-Hernández
- M el-Etr
- M Fernandez
- M Gianfriddo
- M Glass
- M Logan
- M Marchi
- M Marcoli
- M Mayne
- M Okada
- M Schnurr
- M Schwaninger
- M Schwaninger
- M Shaban
- M Tomiyama
- MA Schwarzschild
- MA Wollmer
- MB Jensen
- MC Montesinos
- MC Peakman
- MC Peakman
- MC Wittendorp
- MD Okusa
- MF Pereira
- MG Bouma
- MH O’Regan
- MI Martinez-Mir
- MI Sweeney
- MJ Diógenes
- MJ During
- MJ Hurley
- ML Trincavelli
- MP Abbracchio
- MP Abbracchio
- MP Flavin
- MP Rathbone
- MR Nikbakht
- MS Brodie
- MT Tebano
- MT Tebano
- MV Sitkovsky
- N Bischofberger
- N Braun
- N Gouder
- N Gouder
- N Harada
- N Jiang
- N Rebola
- N Rebola
- N Rebola
- N Rebola
- Neuroinflammation Working Group
- NJ Toms
- NK Huang
- NK Huang
- O Pagonopoulou
- O Sorg
- OP Dall’Igna
- P Agostinho
- P Ballabh
- P Ballerini
- P Bodin
- P Brown
- P Correia-de-Sá
- P Correia-de-Sá
- P Correia-de-Sá
- P Correia-de-Sá
- P Correia-de-Sá
- P Popoli
- P Popoli
- P Popoli
- P Popoli
- P Popoli
- P Robledo
- P Schubert
- P Schubert
- P Svenningsson
- PA Jones
- PA Rosenberg
- PD Alfinito
- PJ Gebicke-Haerter
- PJ Magistretti
- PJ Richardson
- PJ Zhu
- PK Ritchie
- PL Khimenko
- PL Lutz
- PR Turner
- QS Si
- R Brambilla
- R Ciccarelli
- R Ciccarelli
- R Guillet
- R Napieralski
- R Paes-de-Carvalho
- R Reggio
- R Simone de
- RA Barraco
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Olsson
- RF Berman
- RJ Cormier
- RJ Lefkowitz
- RN Kalaria
- Rodrigo A. Cunha
- RW Greene
- S Alloisio
- S Apasov
- S Coco
- S Ferré
- S Ferré
- S Hindley
- S Huang
- S Jin
- S Kobayashi
- S Kobayashi
- S Koizumi
- S Latini
- S Latini
- S McGaraughty
- S Thevananther
- S Tsutsui
- SA Lyons
- SA Rivkees
- SA Rivkees
- SB Cohen
- SD Ross
- SH Platts
- SH Ramirez
- SJ Leibovich
- SM Allan
- SM Brooke
- SM Delaney
- SM Peirce
- SM Thompson
- SM Weiss
- SN Schiffmann
- T Araki
- T Kobayashi
- T Nishizaki
- T Ochiishi
- T Ogata
- T Othman
- T Suzuki
- T Tatlisumak
- TH Swanson
- TM Alfaro
- TV Dunwiddie
- TV Dunwiddie
- TW Stone
- U Aden
- U Aden
- U Aden
- UK Hanisch
- V Dzhala
- VK Gribkoff
- W Tetzlaff
- WF MacDonald
- WG Kim
- WM Behan
- WR Proctor
- XX Li
- Y Gao
- Y Lu
- YJ Day
- YJ Day
- Z Gerevich
- Z Juranyi
- Z Wang
- ZQ Zhao
- Publication venue
- Kluwer Academic Publishers
- Publication date
- 01/01/2005
- Field of study
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A1 receptors (A1Rs) and the less abundant, but widespread, facilitatory A2ARs. It is commonly assumed that A1Rs play a key role in neuroprotection since they decrease glutamate release and hyperpolarize neurons. In fact, A1R activation at the onset of neuronal injury attenuates brain damage, whereas its blockade exacerbates damage in adult animals. However, there is a down-regulation of central A1Rs in chronic noxious situations. In contrast, A2ARs are up-regulated in noxious brain conditions and their blockade confers robust brain neuroprotection in adult animals. The brain neuroprotective effect of A2AR antagonists is maintained in chronic noxious brain conditions without observable peripheral effects, thus justifying the interest of A2AR antagonists as novel protective agents in neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, ischemic brain damage and epilepsy. The greater interest of A2AR blockade compared to A1R activation does not mean that A1R activation is irrelevant for a neuroprotective strategy. In fact, it is proposed that coupling A2AR antagonists with strategies aimed at bursting the levels of extracellular adenosine (by inhibiting adenosine kinase) to activate A1Rs might constitute the more robust brain neuroprotective strategy based on the adenosine neuromodulatory system. This strategy should be useful in adult animals and especially in the elderly (where brain pathologies are prevalent) but is not valid for fetus or newborns where the impact of adenosine receptors on brain damage is different
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
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- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Criteria for the use of omics-based predictors in clinical trials: Explanation and elaboration
- Author
- A Beasley-Green
- A Dupuy
- AA Alizadeh
- AC Janssens
- AE Gelfand
- AM Molinaro
- B Freidlin
- B Freidlin
- Barbara A Conley
- C Ambroise
- C Hans
- C Strand
- Center for Devices and Radiological Health
- CM Perou
- Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
- CR Kinsinger
- D Sargent
- DA Cairns
- David A Eberhard
- Deborah J Shuman
- DG Altman
- DL Tabb
- External RNA Controls Consortium
- F Sun
- FE Harrell
- G Dimeski
- G Kurban
- G Poste
- GM Clark
- H Ishwaran
- HM Moore
- J Brettschneider
- J Brettschneider
- J Fan
- J Subramanian
- JA Sparano
- JA Wilson
- JA Zujewski
- James H Doroshow
- James V Tricoli
- JC Marioni
- JD Thorpe
- Jeremy MG Taylor
- JF Pierson-Perry
- Jill P Mesirov
- JL Hackett
- JM Perkel
- JMG Taylor
- JP Mesirov
- JPA Ioannidis
- JS Krouwer
- JS Parker
- JT Leek
- K Owzar
- Kelly Y Kim
- KGM Moons
- KGM Moons
- KK Dobbin
- KK Dobbin
- L Breiman
- L Buchen
- L Lusa
- L Shi
- L Shi
- LA Habel
- LC Jiang
- Lisa M McShane
- LM McShane
- LM McShane
- LM McShane
- LM McShane
- LW Clark
- M Bantscheff
- M McIntosh
- M Srinivasan
- Margaret M Cavenagh
- Mei-Yin C Polley
- MH Greene
- MH Zweig
- MN McCall
- MS Pepe
- Office of Biorepositories and Biospecimen Research
- P Mickey Williams
- PA Rudnick
- PM Bossuyt
- PM Bossuyt
- R Apweiler
- R Simon
- RA Irizarry
- RA Irizarry
- Richard M Simon
- RL Schilsky
- RM Simon
- S Dudoit
- S Katz
- S Paik
- T Hastie
- T Sorlie
- Tracy G Lively
- US Food and Drug Administration
- US Food and Drug Administration
- US Food and Drug Administration
- V Espina
- William L Bigbee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
High-throughput 'omics' technologies that generate molecular profiles for biospecimens have been extensively used in preclinical studies to reveal molecular subtypes and elucidate the biological mechanisms of disease, and in retrospective studies on clinical specimens to develop mathematical models to predict clinical endpoints. Nevertheless, the translation of these technologies into clinical tests that are useful for guiding management decisions for patients has been relatively slow. It can be difficult to determine when the body of evidence for an omics-based test is sufficiently comprehensive and reliable to support claims that it is ready for clinical use, or even that it is ready for definitive evaluation in a clinical trial in which it may be used to direct patient therapy. Reasons for this difficulty include the exploratory and retrospective nature of many of these studies, the complexity of these assays and their application to clinical specimens, and the many potential pitfalls inherent in the development of mathematical predictor models from the very high-dimensional data generated by these omics technologies. Here we present a checklist of criteria to consider when evaluating the body of evidence supporting the clinical use of a predictor to guide patient therapy. Included are issues pertaining to specimen and assay requirements, the soundness of the process for developing predictor models, expectations regarding clinical study design and conduct, and attention to regulatory, ethical, and legal issues. The proposed checklist should serve as a useful guide to investigators preparing proposals for studies involving the use of omics-based tests. The US National Cancer Institute plans to refer to these guidelines for review of proposals for studies involving omics tests, and it is hoped that other sponsors will adopt the checklist as well. © 2013 McShane et al.; licensee BioMed Central Ltd
Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery
- Author
- A Armstrong
- A Handra-Luca
- AA Maawy
- AAR Higazi
- AJ Boyle
- AL Vahrmeijer
- AL Vahrmeijer
- Alexander L. Vahrmeijer
- B Paudyal
- B Peruzzi
- B Sipos
- B Zhu
- Bert A. Bonsing
- BJ Hackel
- BL Appel
- BR Voldborg
- C Birchmeier
- C Dullin
- C Kari
- C Neuzillet
- CA Metildi
- CA Metildi
- CA Metildi
- CH Heath
- CHJ Ford
- CJ Yeo
- Cornelis F. M. Sier
- Cornelis J. H. van de Velde
- D Cantero
- D Fong
- D Gao
- D Naka
- DE Milenic
- DK Chang
- E Pomianowska
- EF Plow
- EJ Blok
- EL Rosenthal
- F Vilhardt
- FLP Greene
- G Korpanty
- GH Zhu
- GM Dam van
- GY Lee
- H Chen
- Hans Morreau
- Hendrica A. J. M. Prevoo
- HJ Handgraaf
- HL Goel
- HS Tran Cao
- HW Smith
- I Esposito
- J Harding
- J Itakura
- J. Sven D. Mieog
- JH Day
- JL Cameron
- JP Neoptolemos
- JS Desgrosellier
- JS Mieog
- K Haedicke
- K Kiehne
- K Lund
- K Yamaguchi
- KE Day
- KE Day
- KE Day
- KR Choudhury
- L Wang
- L Yang
- L Yang
- L Yang
- LA Aarsen Van
- LD True
- Leonora S. F. Boogerd
- M Hutteman
- M Jessup
- M Komoto
- M Korc
- M Munz
- M Oosten van
- MA Pysz
- MB Melo de
- MC Boonstra
- MD Girgis
- MD Martin-Bermudo
- MF Renzo Di
- MJ Humphries
- MM He
- N Deshpande
- N Normanno
- NR Lemoine
- P Gold
- P Tummala
- Peter J. K. Kuppen
- PTH Went
- QL Qiao
- R Hildenbrand
- R Siegel
- RK Jain
- RP Merkow
- Rutger-Jan Swijnenburg
- S Dadparvar
- S Hammarstrom
- S Kaushal
- S Keereweer
- S Wiehr
- SC Santos
- SH Hausner
- SH Hausner
- SL Timofeevski
- SM Huang
- Susanna W. L. de Geus
- SV Hudson
- T Akiyama
- T Kawamoto
- T Mizukami
- TK Nayak
- TL Moore
- V Guillemard
- V Jankowski
- VA Zorgetto
- W Stummer
- WH Allum
- Willemieke S. F. J. Tummers
- Y Hiroshima
- Y Li
- Y Yamanaka
- Y Yamanaka
- Z Liu
- Z Niu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Observation of triple J/ψ meson production in proton-proton collisions
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aimè C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrecht S
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alonso AG
- Alpana K
- Alvarez JDR
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Anampa KH
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Anguiano J
- Antchev G
- Antequera JB
- Anthony D
- Antunovic Z
- Anuar AAB
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arbol PMRD
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Banos LIE
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrera CB
- Barrera CO
- Barria P
- Bartek R
- Bartosik N
- Bartók M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayatmakou M
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerra DAS
- Bechtel J
- Bedoya CF
- Beghin D
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Bemden MV
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Benitez JF
- Benussi L
- Bergauer T
- Berger P
- Beri SB
- Bernardes CA
- Bernet C
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Bestintzanos I
- Bethani A
- Beyrouthy T
- Bhal E
- Bhardwaj A
- Bharthuar S
- Bharti M
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
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- Bhowmik D
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- Bhyun JH
- Bi R
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- Bianchini L
- Bianco M
- Bianco S
- Bihan A-CL
- Biino C
- Bilei GM
- Bilin B
- Bindhu VKMN
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- Bluj M
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- Bocci A
- Bodek A
- Boimska B
- Boldrini G
- Boletti A
- Bologna S
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- Bonacorsi D
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- Bonham B
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- Bonomally S
- Boos E
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- Bourilkov D
- Bouza VR
- Bozzo M
- Bragagnolo A
- Braghieri A
- Brainerd C
- Branson JG
- Breedon R
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- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brom J-M
- Brommer S
- Brooke JJ
- Brown RM
- Brunner D
- Bruno G
- Bruyn ID
- Bryant P
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- Brzhechko D
- Brücken E
- Bucci R
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- Burgo RD
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- Burt K
- Bury F
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- Busza W
- Butalla S
- Butler JN
- Butler PH
- Butz E
- Bychkova O
- Bylinkin A
- Bylsma B
- Bärtschi P
- Caballero IG
- Cabrera A
- Cabrillo IJ
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- Caillol C
- Cakir A
- Calandri A
- Calderon A
- Cali IA
- Calligaris L
- Calzaferri S
- Camen C
- Caminada L
- Campagnari C
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- Campanini R
- Campbell A
- Campderros JD
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
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- Capiluppi P
- Cappati A
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- Chauhan S
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- Chernyavskaya N
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- Chistov R
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- Choudhury S
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- Christoforou K
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- Ciangottini D
- Cifuentes JAB
- Ciocci MA
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- Cittolin S
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- Clerbaux B
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- Özçelik Ö
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/01/2023
- Field of study
Data availability:
Tabulated results are provided in the HEPData record for this analysis71. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in CMS data preservation, re-use and open access policy.Code availability:
The CMS core software is publically available at https://github.com/cms-sw/cmssw.Copyright . Protons consist of three valence quarks, two up-quarks and one down-quark, held together by gluons and a sea of quark-antiquark pairs. Collectively, quarks and gluons are referred to as partons. In a proton-proton collision, typically only one parton of each proton undergoes a hard scattering – referred to as single-parton scattering – leaving the remainder of each proton only slightly disturbed. Here, we report the study of double- and triple-parton scatterings through the simultaneous production of three J/ψ mesons, which consist of a charm quark-antiquark pair, in proton-proton collisions recorded with the CMS experiment at the Large Hadron Collider. We observed this process – reconstructed through the decays of J/ψ mesons into pairs of oppositely charged muons – with a statistical significance above five standard deviations. We measured the inclusive fiducial cross-section to be 272+141−104(stat)±17(syst)fb, and compared it to theoretical expectations for triple-J/ψ meson production in single-, double- and triple-parton scattering scenarios. Assuming factorization of multiple hard-scattering probabilities in terms of single-parton scattering cross-sections, double- and triple-parton scattering are the dominant contributions for the measured process.SCOAP3.Change history:
27 February 2023A Correction to this paper has been published: https://doi.org/10.1038/s41567-023-01992-
Recommended from our members
Search for electroweak production of charginos and neutralinos at s = 13 TeV in final states containing hadronic decays of WW, WZ, or WH and missing transverse momentum
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- Zghiche A
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Elsevier
- Publication date
- 15/09/2022
- Field of study
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in “CMS data preservation, re-use and open access policy”.A preprint version of this article is archived at: arXiv:2205.09597v2 [hep-ex], https://arxiv.org/abs/2205.09597v2 . Comments: Replaced with the published version. Added the journal reference. All the figures and tables, including additional supplementary figures and tables, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/SUS-21-002 (CMS Public Pages). Report number: CMS-SUS-21-002, CERN-EP-2022-031This Letter presents a search for direct production of charginos and neutralinos via electroweak interactions. The results are based on data from proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb^{-1}. The search considers final states with large missing transverse momentum and pairs of hadronically decaying bosons WW, WZ, and WH, where H is the Higgs boson. These bosons are identified using novel algorithms. No significant excess of events is observed relative to the expectations from the standard model. Limits at the 95% confidence level are placed on the cross section for production of mass-degenerate wino-like supersymmetric particles χ~±1 and χ~02, and mass-degenerate higgsino-like supersymmetric particles χ~±1, χ~02, and χ~03. In the limit of a nearly-massless lightest supersymmetric particle χ~01, wino-like particles with masses up to 870 and 960 GeV are excluded in the cases of χ~02 → Zχ~01 and χ~02 → Hχ~01, respectively, and higgsino-like particles are excluded between 300 and 650 GeV.SCOAP3
Recommended from our members
Search for new heavy resonances decaying to WW, WZ, ZZ, WH, or ZH boson pairs in the all-jets final state in proton-proton collisions at s = 13 TeV
- Author
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- Wyslouch B
- Würthwein F
- Xiang Y
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- Xiao M
- Xiao R
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- Yagil A
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- Yan F
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- Yockey H
- Yohay R
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- Yu D
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- Yu PR
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- Yumiceva F
- Yusuff I
- Zabi A
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- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeuner WD
- Zghiche A
- Zhang F
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- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Elsevier
- Publication date
- 26/02/2023
- Field of study
A preprint version of this article is available at arXiv:2210.00043v2 [hep-ex], https://arxiv.org/abs/2210.00043v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-009 (CMS Public Pages). Report number: CMS-B2G-20-009, CERN-EP-2022-152.Data availability: see: https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-009 .A search for new heavy resonances decaying to WW, WZ, ZZ, WH, or ZH boson pairs in the all-jets final state is presented. The analysis is based on proton-proton collision data recorded by the CMS detector in 2016-2018 at a centre-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 138 fb^{-1}. The search is sensitive to resonances with masses between 1.3 and 6 TeV, decaying to bosons that are highly Lorentz-boosted such that each of the bosons forms a single large-radius jet. Machine learning techniques are employed to identify such jets. No significant excess over the estimated standard model background is observed. A maximum local significance of 3.6 standard deviations, corresponding to a global significance of 2.3 standard deviations, is observed at masses of 2.1 and 2.9 TeV. In a heavy vector triplet model, spin-1 Z' and W' resonances with masses below 4.8 TeV are excluded at the 95% confidence level (CL). These limits are the most stringent to date. In a bulk graviton model, spin-2 gravitons and spin-0 radions with masses below 1.4 and 2.7 TeV, respectively, are excluded at 95% CL. Production of heavy resonances through vector boson fusion is constrained with upper cross section limits at 95% CL as low as 0.1 fb.SCOAP3
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