Understanding the Transformation of the IT Function in Organizations

Many IT researchers have tried to describe the IT function and to explain its transformation over time. Nevertheless, we observed that existing characterizations are often based on a single dimension, attached to historical periods or built into a normative discourse that calls for an ideal profile. We do not subscribe to these premises, seeing that there might be a series of distinct archetypes for the IT function, and that each archetype may adapt and evolve in response to organizational and environmental parameters. Based on a literature review, we propose a typology of the roles of IT functions, within archetypes that are defined according to four dimensions: the IT function’s main activities, the skills of IT professionals, the interface between the IT function and the organization’s business units, and the IT function’s governance. Next, using the theory of punctuated equilibria as a foundation, we will apply the proposed typology to investigate the process by which IT functions evolve over time. From a methodological standpoint, we will first conduct a series of interviews with IT executives to validate the proposed typology. Second, we will conduct a longitudinal case study in the healthcare sector to explain how and why an IT function transforms over time and discover forces that foster stasis or inspire change. Ultimately, our study will provide a new conceptual and theoretical perspective on the role and transformation of IT functions in organizations

Rapidity Spectra Analysis in Terms of Non Extensive Statistic Approach

We provide description of rapidity spectra of particles produced in p-anti-p collisions using anomalous diffusion approach to account for their non-equilibrium character. In particular, we exhibit connection between multiproduction processes and anomalous diffusion described through the nonlinear Focker-Planck equation with nonlinearity given by the nonextensivity parameter q describing the underlying Tsallis q-statistics and demonstrate how it leads to the Feynman scaling violation in these collisions. The q parameter obtained this way turns out to be closely connected to parameter 1/k converting the original poissonian multiplicity distribution to its observed Negative Binomial form. The inelasticity of reaction has been also calculated and found to slightly decrease with the increasing energy of reaction. Keywords: inelasticity, rapidity spectra, nonextensivityComment: 4 pages, 4 figures, Presented at XII International Symposium on Very High Energy Cosmic Ray Interactions, CERN, Switzerland, 15-20 July 200

The Gordon-Haus effect for modified NLS solitons

Random jitter in the soliton arrival time (the Gordon-Haus effect) is analyzed for solitons being solutions of the integrable modified nonlinear Schroedinger equation. It is shown that the mean square fluctuation of the soliton position depends on the soliton parameters which can be properly adjusted to suppress the Gordon-Haus jitter.Comment: LaTeX, 7 pages, 3 figures, to be published in Europhys. Let

A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - the Diet and Genetic Intervention (DIGEST) Pilot study

Background Risk of cardiovascular disease (CVD) can be increased by single-nucleotide polymorphisms (SNPs) in the 9p21 region of the genome. However, observational studies have shown that the deleterious effect of 9p21 SNPs on CVD might be offset by consuming a diet rich in fresh fruits and vegetables. This association may be driven by diet-influenced modifications in epigenetic and gene expression profiles. In this pilot study, we aimed to: i. test the feasibility of provision of a ‘Prudent’ and ‘Western’ diet outside of a specialized clinic, ii. assess the impact of each diet on cardiovascular risk factors. Methods A single centre, parallel two-arm, pilot randomized controlled trial (RCT) with food provision was conducted in a university teaching hospital outpatient clinic (McMaster university, Hamilton, ON, Canada). The aim was to recruit 80 participants, which allowed for a 10 % dropout. The actual study consisted of 84 apparently healthy participants (69 % women, 18 to 77 years) at low cardiovascular risk. Participants were randomly assigned to follow one of two weight-maintaining diets: ‘Prudent’ or ‘Western’ for 2-weeks. The Prudent diet provided 92 % of provided food consumed). The Prudent diet was 48 % more palatable than the Western diet (P < 0.05). Participants receiving the Prudent diet showed a trend toward reduced systolic (-4 mmHg; P = 0.10) and diastolic (-3 mmHg; P = 0.07) blood pressure, and total cholesterol (-0.24 mmol/L; P = 0.08), compared to individuals receiving the Western diet. Data collection from all randomized participants was completed within 18 months. Conclusions Recruitment, and retention of apparently healthy, normotensive adults into a feeding study for a 2-week duration is feasible outside of specialized dietary clinic, and modest diet-related changes in biomarkers begin to appear after two weeks

Estimating the inelasticity with the information theory approach

Using the information theory approach, in both its extensive and nonextensive versions, we estimate the inelasticity parameter $K$ of hadronic reactions together with its distribution and energy dependence from $p\bar{p}$ and $pp$ data. We find that the inelasticity remains essentially constant in energy except for a variation around $K\sim 0.5$, as was originally expected.Comment: 14 pages, 8 figures. Misprints correcte

Spectrum and Variability of Mrk501 as observed by the CAT Imaging Telescope

The CAT Imaging Telescope has observed the BL Lac object Markarian 501 between March and August 1997. We report here on the variability over this time including several large flares. We present also preliminary spectra for all these data, for the low emission state, and for the largest flare.Comment: 4 pages, 4 figures, Late

Observation of the Crab Nebula Gamma-Ray Emission Above 220 Gev by the Cat Cherenkov Imaging Telescope

The CAT imaging telescope, recently built on the site of the former solar plant Themis (French Pyrenees), observed gamma-rays from the Crab nebula from October 1996 to March 1997. This steady source, often considered as the standard candle of very-high-energy gamma-ray astronomy, is used as a test-beam to probe the performances of the new telescope, particularly its energy threshold (220 GeV at 20 degrees zenith angle) and the stability of its response. Due to the fine-grain camera, an accurate analysis of the longitudinal profiles of shower images is performed, yielding the source position in two dimensions for each individual shower.Comment: 5 pages, 3 figures, Tex, contribution to 25th ICRC Durba

Detection of Vhe Gamma-Rays from MRK 501 with the Cat Imaging Telescope

The CAT imaging telescope on the site on the former solar plant Themis has been observing gamma-rays from Mrk501 above 220 GeV in March and April 1997. This source is shown to be highly variable and the light curve is presented. The detected gamma-ray rate for the most intense flare is in excess of 10 per minute.Comment: 5 pages, 4 figures, Tex, contribution to 25th ICRC Durba

Metastatic site patterns by intrinsic subtype and HER2DX in early HER2-positive breast cancer

Background: Even with contemporary treatment strategies, more than 10% of HER2-positive early stage breast cancer patients may experience distant metastasis as first event during follow-up. Tools for predicting unique patterns of metastatic spread are needed to plan personalized surveillance. We evaluated how molecular heterogeneity affects the pattern of distant relapse in HER2-positive breast cancer. Methods: A total of 677 HER2-positive stage I-III breast cancer patients from ShortHER trial, Cher-LOB trial, and 2 institutional cohorts were included. PAM50 molecular subtypes and research-based HER2DX scores were evaluated. The cumulative incidence of distant relapse as the first event (any site and site specific) was evaluated using competing risk analysis. Median follow-up was 8.4 years. Tests of statistical significance are 2-sided. Results: Stage III and high HER2DX risk score identified patients at the highest risk of distant relapse as first event (10-year incidence 24.5% and 19.7%, respectively). Intrinsic molecular subtypes were associated with specific patterns of metastatic spread: compared with other subtypes, HER2-enriched tumors were more prone to develop brain metastases (10-year incidence 3.8% vs 0.6%, P =. 005), basal-like tumors were associated with an increased risk of lung metastases (10-year incidence 11.1% vs 2.6%, P =. 001), and luminal tumors developed more frequently bone-only metastases (10-year incidence 5.1% vs 2.0%, P =. 042). When added to stage or HER2DX risk score in competing risk regression models, intrinsic subtype maintained an independent association with site-specific metastases. Conclusions: The integration of intrinsic molecular subtypes with stage or HER2DX risk score predicts site-specific metastatic risk in HER2-positive breast cancer, with potential implications for personalized surveillance and clinical trials aimed at preventing site-specific recurrence