The psychological therapy preferences of patients who hear voices

Background Voice-hearing is a common, phenomenologically diverse, experience across different mental health diagnoses. Patient preferences for psychological therapies are helpful in informing treatment commissioning and provision, especially in the context of complex and variable experiences like voice-hearing. There is, however, very limited evidence as to the psychological therapy preferences of transdiagnostic voice-hearers. Methods Three-hundred and thirty-five voice hearers were recruited from secondary care NHS mental health services across England, between 2020 and 2022. Participants completed a questionnaire battery, involving a psychological therapy preference survey. Participants ranked their preferences across categories of practical, technical and relational therapy elements. Therapy preferences were examined using non-parametric ANOVAs and the significance of pairwise comparisons between different therapy elements. Results There were significant differences in all categories of preference elements. Clear hierarchies of preference were observed in therapy location, timing, delivery, and therapy approach. Preferences were evident, albeit with less clear vertical hierarchies, for number of sessions, mode, therapist qualities, and therapy focus, tasks and outcomes. Discussion Overall, participants expressed a preference for individual, face-to-face intervention of at least nine sessions, with a highly experienced therapist and a core focus on enhancing coping strategies for voice-hearing experiences

Modelling aromatisation of (BN)nH2n azabora-annulenes

Despite a long tradition of descriptions of borazine as an ‘inorganic benzene’, this molecule is a non-aromatic species according to the magnetic (ring-current) criterion. Borazine, borazocine, and the larger neutral (BN)nH2n azabora-annulene heterocycles in planar conformations, although π-isoelectronic with [2n]annulenes, support only localized induced currents in perpendicular magnetic fields. The π-current maps of these systems comprise superpositions of separate ‘lone-pair’ circulations on all nitrogen centres. For the systems with n > 4, planarity must be enforced by a constraint. Qualitative orbital analysis based on the ipsocentric approach to calculation of induced current density suggests that global induced currents could be produced through strategic changes to the π electron count. In ab initio calculations, azabora-annulenes with rings of size [8]- and larger were indeed found to support global diatropic ring currents in both anionic and cationic forms with (4N + 2) π electron counts. The planar conformation of the charged ring typically occupies a stationary point of higher order on the potential energy surface, rather than a minimum. However, the borazocine dianion, [B4N4H8]2−, occupies a planar minimum, supports a diatropic ring current of strength comparable to that in benzene, and is predicted to participate in sandwich compounds; it is therefore a good candidate for an aromatised azabora-annulene

Pattern densities in fluid dimer models

In this paper, we introduce a family of observables for the dimer model on a bi-periodic bipartite planar graph, called pattern density fields. We study the scaling limit of these objects for liquid and gaseous Gibbs measures of the dimer model, and prove that they converge to a linear combination of a derivative of the Gaussian massless free field and an independent white noise.Comment: 38 pages, 3 figure

Quantum magneto-oscillations in a two-dimensional Fermi liquid

Quantum magneto-oscillations provide a powerfull tool for quantifying Fermi-liquid parameters of metals. In particular, the quasiparticle effective mass and spin susceptibility are extracted from the experiment using the Lifshitz-Kosevich formula, derived under the assumption that the properties of the system in a non-zero magnetic field are determined uniquely by the zero-field Fermi-liquid state. This assumption is valid in 3D but, generally speaking, erroneous in 2D where the Lifshitz-Kosevich formula may be applied only if the oscillations are strongly damped by thermal smearing and disorder. In this work, the effects of interactions and disorder on the amplitude of magneto-oscillations in 2D are studied. It is found that the effective mass diverges logarithmically with decreasing temperature signaling a deviation from the Fermi-liquid behavior. It is also shown that the quasiparticle lifetime due to inelastic interactions does not enter the oscillation amplitude, although these interactions do renormalize the effective mass. This result provides a generalization of the Fowler-Prange theorem formulated originally for the electron-phonon interaction.Comment: 4 pages, 1 figur

Molecular dynamics simulation of the order-disorder phase transition in solid NaNO2_2

We present molecular dynamics simulations of solid NaNO$_2$ using pair potentials with the rigid-ion model. The crystal potential surface is calculated by using an \emph{a priori} method which integrates the \emph{ab initio} calculations with the Gordon-Kim electron gas theory. This approach is carefully examined by using different population analysis methods and comparing the intermolecular interactions resulting from this approach with those from the \emph{ab initio} Hartree-Fock calculations. Our numerics shows that the ferroelectric-paraelectric phase transition in solid NaNO$_2$ is triggered by rotation of the nitrite ions around the crystallographical c axis, in agreement with recent X-ray experiments [Gohda \textit{et al.}, Phys. Rev. B \textbf{63}, 14101 (2000)]. The crystal-field effects on the nitrite ion are also addressed. Remarkable internal charge-transfer effect is found.Comment: RevTeX 4.0, 11 figure

Path-Integral bosonization of a non-local interaction and its application to the study of 1-d many-body systems

We extend the path-integral approach to bosonization to the case in which the fermionic interaction is non-local. In particular we obtain a completely bosonized version of a Thirring-like model with currents coupled by general (symmetric) bilocal potentials. The model contains the Tomonaga-Luttinger model as a special case; exploiting this fact we study the basic properties of the 1-d spinless fermionic gas: fermionic correlators, the spectrum of collective modes, etc. Finally we discuss the generalization of our procedure to the non-Abelian case, thus providing a new tool to be used in the study of 1-d many-body systems with spin-flipping interactions.Comment: 26 pages LATEX, La Plata 94-0

Targeting the Canonical Nuclear Factor-κB Pathway with a High-Potency IKK2 Inhibitor Improves Outcomes in a Mouse Model of Idiopathic Pneumonia Syndrome

Idiopathic pneumonia syndrome (IPS) is a noninfectious inflammatory disorder of the lungs that occurs most often after fully myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). IPS can be severe and is associated with high 1-year mortality rates despite existing therapies. The canonical nuclear factor-(NF) κB signaling pathway has previously been linked to several inflammatory disorders of the lung, including asthma and lung allograft rejection. It has never been specifically targeted as a novel IPS treatment approach, however. Here, we report that the IκB kinase 2 (IKK2) antagonist BAY 65-5811 or “compound A,” a highly potent and specific inhibitor of the NF-κB pathway, was able to improve median survival times and recipient oxygenation in a well-described mouse model of IPS. Compound A impaired the production of the proinflammatory chemokines CCL2 and CCL5 within the host lung after transplantation. This resulted in significantly lower numbers of donor lung infiltrating CD4+ and CD8+ T cells and reduced pulmonary inflammatory cytokine production after allograft. Compound A's beneficial effects appeared to be specific for limiting pulmonary injury, as the drug was unable to improve outcomes in a B6 into B6D2 haplotype-matched murine HSCT model in which recipient mice succumb to lethal acute graft-versus-host disease of the gastrointestinal tract. Collectively, our data suggest that the targeting of the canonical NF-κB pathway with a small molecule IKK2 antagonist may represent an effective and novel therapy for the specific management of acute lung injury that can occur after allogeneic HSCT

Raman Deuterium Isotope Probing Reveals Microbial Metabolism at the Single-Cell Level

We illustrate that single-cell Raman microspectroscopy, coupled with deuterium isotope probing (Raman-DIP), provides a culture-independent and nondestructive approach to probe metabolic pathways of carbon substrates at the single-cell level. We found a distinguishable C-D vibration band at 2070-2300 cm-1 in single-cell Raman spectra (SCRS) when Escherichia coli used deuterated glucose and Pseudomonas sp. used deuterated naphthalene as sole carbon sources. The intensity of the C-D band is proportional to the extent of deuteration in the carbon source, and as little as 5% deuteration can be distinguished by analysis of SCRS. It suggests that Raman-DIP could be used to semiquantitatively and sensitively indicate the metabolism of deuterated carbon source in microbes. A lower lipid conversion rate of deuterated naphthalene compared to that of deuterated glucose was observed, presumably owing to different anabolic pathways and membrane alteration. Apart from the C-D band shift from C-H, SCRS also reveal several isotopic shifts of the phenylalanine band, of which the positions correlate well with a computational model. A reduction in phenylalanine deuteration in Pseudomonas sp. compared to that in E. coli is due to the dilution effect of different pathways of phenylalanine biosynthesis in Pseudomonas sp. Collectively, we demonstrate that Raman-DIP can not only indicate metabolic activity using deuterated carbon sources but also reveal different metabolic pathways by analyzing SCRS. By harnessing such low-cost and versatile deuterated substrates, Raman-DIP has the potential to probe a wide range of metabolic pathways and functions at the single-cell level

Astrophysical Reaction Rates for 10^{10}B(p,α\alpha)7^{7}Be and 11^{11}B(p,α\alpha)8^{8}Be From a Direct Model

The reactions $^{10}$B(p,$\alpha$)$^{7}$Be and $^{11}$B(p,$\alpha$)$^{8}$Be are studied at thermonuclear energies using DWBA calculations. For both reactions, transitions to the ground states and first excited states are investigated. In the case of $^{10}$B(p,$\alpha$)$^{7}$Be, a resonance at $E_{Res}=10$ keV can be consistently described in the potential model, thereby allowing the extension of the astrophysical $S$-factor data to very low energies. Strong interference with a resonance at about $E_{Res}=550$ keV require a Breit-Wigner description of that resonance and the introduction of an interference term for the reaction $^{10}$B(p,$\alpha_1$)$^{7}$Be$^*$. Two isospin $T=1$ resonances (at $E_{Res1}=149$ keV and $E_{Res2}=619$ keV) observed in the $^{11}$B+p reactions necessitate Breit-Wigner resonance and interference terms to fit the data of the $^{11}$B(p,$\alpha$)$^{8}$Be reaction. $S$-factors and thermonuclear reaction rates are given for each reaction. The present calculation is the first consistent parametrization for the transition to the ground states and first excited states at low energies.Comment: 27 pages, 5 Postscript figures, uses RevTex and aps.sty; preprint also available at http://quasar.physik.unibas.ch/ Phys. Rev. C, in pres