CARBOHYDRATES, ORGANIC-ACIDS AND ANTHOCYANIN OF EUGENIA-JAMBOLANA LAMARCK

21429629

DE-ESTERIFICATION OF CITRUS PECTIN

212110

Representações sociais da relação auxiliar de enfermagem-usuário no contexto do Programa Saúde da Família Representaciones sociales de la relación auxiliar de enfermería-usuario en el contexto del Programa de Salud de la Familia Social representations of the relationship between the nursing assistant and the user in the Health Program context

Os profissionais da enfermagem têm se responsabilizado pela "arte" de cuidar, sendo eles os que dedicam a maior parte do seu tempo ao usuário. Neste estudo, objetivou-se compreender a relação entre auxiliar de enfermagem e usuário através das representações sociais do ato de tocar, construídas por esses profissionais no contexto do Programa Saúde da Família (PSF). Trata-se de uma pesquisa quali-quantitativa com 25 profissionais. Os instrumentos utilizados foram: associação livre de palavras, entrevista e questionário. Evidenciou-se que o toque representa possibilidades de aproximação entre profissional-usuário, expressando-se na prática cotidiana, pois auxilia na cura do usuário e humaniza a relação.<br>Los profesionales de la enfermería tienen se responsabilizado por la "arte" de cuidar, siendo los que dedican la mayor parte de su tiempo al usuario. El objetivo de este trabajo es comprender la relación entre auxiliar de enfermería-usuario por las representaciones sociales del acto de tocar construidas por esos profesionales en el Programa Salud de la Familia. Se trata de una investigación cuali-cuantitativa con 25 profesionales. Los instrumentos utilizados fueron: asociación libre de palabras, entrevista y cuestionario. Se evidenció que el toque representa posibilidades de aproximación entre profesional-usuario, expresándose en la práctica cotidiana, pues posibilita la cura del usuario y humaniza la relación.<br>Nursing professionals have themselves held liable for the "art" of take care of the users and are the ones who dedicate the major part of their time to them. The aim of this study is to understand the relationship between the nursing assistant and the user expressed by the social representations of the touch act by these professionals in the Family Health Program (PSF) context. The qualitative-quantitative research involved 25 nursing assistants. The instruments utilized were: free word association, interview, and questionnaire. It was observed that the touch represents possibilities of approximation between the professional and the user, as it helps in the user’s cure and humanizes the relationship

Desymmetrization of difluoromethylene groups by C–F bond activation

Tertiary stereogenic centres containing one fluorine atom are valuable for medicinal chemistry because they mimic common tertiary stereogenic centres containing one hydrogen atom, but they possess distinct charge distribution, lipophilicity, conformation and metabolic stability1-3. Although tertiary stereogenic centres containing one hydrogen atom are often set by enantioselective desymmetrization reactions at one of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocentres containing fluorine have not yet been constructed by the analogous desymmetrization reaction at one of the two carbon-fluorine (C-F) bonds of a difluoromethylene group3. Fluorine atoms are similar in size to hydrogen atoms but have distinct electronic properties, causing C-F bonds to be exceptionally strong and geminal C-F bonds to strengthen one another4. Thus, exhaustive defluorination typically dominates over the selective replacement of a single C-F bond, hindering the development of the enantioselective substitution of one fluorine atom to form a stereogenic centre5,6. Here we report the catalytic, enantioselective activation of a single C-F bond in an allylic difluoromethylene group to provide a broad range of products containing a monofluorinated tertiary stereogenic centre. By combining a tailored chiral iridium phosphoramidite catalyst, which controls regioselectivity, chemoselectivity and enantioselectivity, with a fluorophilic activator, which assists the oxidative addition of the C-F bond, these reactions occur in high yield and selectivity. The design principles proposed in this work extend to palladium-catalysed benzylic substitution, demonstrating the generality of the approach

Il diritto alla propria identit&#224; di fronte al binarismo di sesso e genere

5-Endo-trig cyclizations are generally considered to be kinetically unfavourable, as described by Baldwin's rules. Consequently, observation of this mode of reaction under kinetic control is rare. This is usually ascribed to challenges in achieving appropriate approach trajectories for orbital overlap in the transition state. Here, we describe a highly enantio- and diastereoselective route to complex indanes bearing all-carbon quaternary stereogenic centres via a 5-endo-trig cyclization catalysed by a chiral ammonium salt. Through computation, the preference for the formally disfavoured 5-endo-trig Michael reaction over the formally favoured 5-exo-trig Dieckmann reaction is shown to result from thermodynamic contributions to the innate selectivity of the nucleophilic group, which outweigh the importance of the approach trajectory as embodied by Baldwin's rules. Our experimental and theoretical findings demonstrate that geometric and stereoelectronic constraints may not be decisive in the observed outcome of irreversible ring-closing reactions