Values’ family flow: associations between grandparents, parents and adolescent children

The present study analyzed cross-generational trends in values and family patterns of value association across three generations (grandparents, parents and children). In this study, 101 family triads with adolescent children (N = 303) completed questionnaires assessing personal values. Grandparents’ values (Generation 1) were measured through parents’ perceptions of their own parents. In general, parents prioritize collectivist values, and there is an increased focus on individualist values across generations. Fathers’ individualist values mediate the relationship between their perceptions of grandfathers’ individualist values and grandchildren’s individualist values. There is no family association of collectivist values. The article outlines the implications of the increasing adherence to individualism and hypothesizes that the adherence of individualist values across families with adolescent children is a pathway to maintenance of family cohesion and cooperation. The role of fathers and the paternal lineage on adolescents’ acquisition of values are discussed.Fundação para a Ciência e Tecnologia [grant number SFRH/BD/62182/200

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

"Organización, fragmentación y posibilidades de cambio: la brecha como vacío fértil"

En este trabajo buscamos comprender los complejos procesos de aprendizaje colectivo, y explorar y diseñar herramientas que posibiliten desarrollarlo. De este modo, observamos brechas y fragmentaciones en la red organizativa, que se enquistan en un vacío estéril que impide el flujo y tensión creativa que requieren los procesos de transformación y cambio. Primeramente se explicitan conceptos, seguido de ejemplos de brechas en torno a las cuales venimos trabajando. Finalmente concluimos con una síntesis integradora para abrir nuevos horizontes que nos conduzcan a una articulación compleja de dichas brechas