758 research outputs found
Biomonitoring polybrominated diphenyl ethers in lactating women
Breast milk is a valuable biological specimen for biomonitoring lipid-soluble polybrominated diphenyl ethers (PBDEs). The goal of this project was to determine the levels of PBDEs in breast milk of lactating women from the Seacoast region of New Hampshire and to examine potential relationships between PBDE levels in breast milk and stage of lactation, maternal characteristics, living environment and dietary intake. Forty women, ages 22 to 40, provided up to three breast milk samples at the end of their first, second and third month of breastfeeding for evaluation of day-to-day and month-to-month variation in PBDE levels. Participants were asked to complete four questionnaires, which provided maternal, living environment, and diet information. The sum of PBDE (SigmaPBDE) congeners found in breast milk was defined as: BDE-28/33, 47, 85, 99, 100, 153, 154, and 183. The SigmaPBDE concentrations in breast milk over the three-month collection period ranged from 6.5 to 166.7 ng/g lipid. The median for the three-month period was 29.7 ng/g. BDE-47 was the predominant congener; however, BDE-153 predominated in 20% of the participants\u27 samples from each month. Day-to-day variation in SigmaPBDEs was negligible; there was no significant difference in mean PBDE levels from month-to-month. Regression analyses revealed relationships between log-transformed PBDE levels in breast milk and questionnaire data. Positive associations were seen between BDE-153 and age (r = 0.36 p = 0.02), saturated fat consumption (r = 0.31 p = 0.05), and the home model (r = 0.51 p = 0.004). There was a negative association between PBDE levels (Sigma and BDE-47) and fruit consumption (r = 0.36 p = 0.02, SigmaPBDE). Our results indicate that PBDE levels in breast milk from New Hampshire are within the range that has been reported in the U.S., and that levels are stable during the first three-months of lactation. Our findings revealed a higher predominance pattern with BDE-153 compared to other studies, and indicate that PBDE levels are influenced by age, diet, and the home environment
Right to Play and Right to Health: the Role of Sub-Saharan Sport for Development Programs in the HIV/AIDS Pandemic
Using the foundation of a childâs right of health and right to play, programs in sub-Saharan Africa are making unique and powerful contributions to combatting and educating youth regarding HIV/AIDS. Through critical analysis of the programsâ successes and failures, I draw conclusions on the reach of sport programs in mitigating the disease and thus combatting global poverty and draw inferences regarding the direction sport for health development programs should be taking to lessen HIV/AIDS infection rates. Subsequently, I identify two areas for growth for sport for development programs: greater outreach to young women and working in partnerships with other key constituents, specifically in the education, healthcare and political sectors (see Appendix A). Overall I conclude that although future research and expansion of programs is needed, sport for development programs are making valuable contributions to both furthering childrenâs unalienable rights of bodily health and play as well as combatting the spread of HIV/AIDS
The Church in the Dramas of T. S. Eliot
From the desolation of a sterile Waste Land populated by straw men, Eliot\u27s dramas increasingly portray a world of great meaning and hope. His early dramas portray a hostile and insensible world which must be fought and completely rejected by religious persons who are called to martyrdom and sainthood. Eliot\u27s acceptance of the material world and comfort with its society brings a steady transformation of his spiritual vision when at the end of his dramas the world is one of common people who strive to find meaning and make the best of a bad job, illumined by a vision of love. Especially this is seen when the rigidly drawn world forces gradually relax into common people open to change and amelioration of the human predicament, not dulled and insensible to any high destiny. A world in early plays described as waste and void becomes a brave new world in the last drama, The Elder Statesman, which most resembles the last Shakesperian world view of The Tempest with its emphasis on perfected love between men. The beneficial change in man\u27s life and the strength of the bond of love displayed increasingly throughout the dramas portray in secular terms Eliot\u27s evolving vision of the Church
Infantsâ attention during cross-situational word learning: Environmental variability promotes novelty preference
Infants as young as 14 months can track cross-situational statistics between sets of words and objects to acquire wordâreferent mappings. However, in naturalistic word learning situations, words and objects occur with a host of additional information, sometimes noisy, present in the environment. In this study, we tested the effect of this environmental variability on infantsâ word learning. Fourteen-month-old infants (N = 32) were given a cross-situational word learning task with additional gestural, prosodic, and distributional cues that occurred reliably or variably. In the reliable cue condition, infants were able to process this additional environmental information to learn the words, attending to the target object during test trials. But when the presence of these cues was variable, infants paid greater attention to the gestural cue during training and subsequently switched preference to attend more to novel wordâobject mappings rather than familiar ones at test. Environmental variation may be key to enhancing infantsâ exploration of new information
Participatory citizens and hybrid cities:imagining green spaces in Manchester's Northern Quarter
This paper presents an innovative community project through the notion of research through design. With Manchester as our hybrid city backdrop, we look specifically at community greening groups in the Northern Quarter (NQ). Thirty-four participants attended 12 conversations that asked: how do you respond to a greening challenge with the digital communication and technology you carry with you? Through the use of IDEO and D:Schoolâs Empathy Map we reveal conversational themes that will inform a design challenge
How do staff in an inpatient adolescent service talk about and understand young people's mental health difficulties?
Receiver Geometries for Solar Dish Concentrators
This thesis studies receiver/reactor geometry for the ammonia
thermochemical storage system and dish concentrators, using the
case study of a masked 9âŻm2 dish. Experimental results proved
that altering the geometric arrangement â in this case the cone
angle â of reactor tubes within a cavity receiver significantly
affects the heat transfers within and heat losses from the
receiver. By consequence both the receiver efficiency and the
solar-to-chemical efficiency of the dish-receiver system can be
significantly increased. This is note-worthy as improvements in
efficiency due to reactor tube cone angle do not increase the
cost of manufacture of the receiver. Moreover, any increase in
receiver efficiency allows an equivalent decrease in mirror area,
and in a commercial plant, the solar collector field (mirror
area) can account for around 40% of total project costs.
Gains of up to 7.0% absolute in receiver efficiency and 6.4%
absolute in solar-to-chemical efficiency were demonstrated
experimentally in this thesis at a given solar altitude.
Experimental data was examined for three receiver configurations
with reactor tube half cone angles of 17.5Âș, 7.5Âș and 3.7Âș,
with the 3.7Âș configuration producing the highest receiver
efficiencies, the 7.5Âș receiver a close second, and the 17.5Âș
configuration producing the lowest efficiencies.
Solar-to-chemical efficiencies were however slightly higher for
the 7.5Âș configuration than the 3.7Âș, indicating that
system-level operation, especially operation of the heat
exchanger, was slightly more optimal for the 7.5Âș case.
Preliminary results integrating the receiver losses over the
course of a year indicate that the 3.7Âș receiver geometry would
reduce annual receiver losses by 25% compared to the 17.5Âș
receiver geometry.
The experimental data comprised 178 hours of âon sunâ
operation of the 9âŻm2 dish concentrator by the author,
providing 311 steady state intervals of 10-15 minutes. The
experimental results were compared with simulations using an
existing computational receiver/reactor model, but gross
disagreement was observed. Simulated reaction extents were 2-4
times those achieved experimentally. Therefore a new energy
balance was developed for each of the three receiver geometries.
This included 3D modelling of radiation losses, along with
calculation of convection and conduction losses, and used the
knowledge gained experimentally of reactor tube and cavity wall
temperature profiles. These new energy balances were verified
against a substantial body of experimental data â out of 86
steady-state data points at optimal flow, calculated receiver
losses fell within the experimental uncertainties for all but
seven points. The energy balances allowed curves of predicted
receiver losses to be generated for each of the three receiver
geometries over a wider range of temperatures and solar
altitudes. These curves suggest that the 3.7Âș half cone receiver
would still have the lowest receiver losses under all operating
conditions, closely followed by the 7.5Âș half cone receiver. At
mid and low solar altitudes, natural convection losses dominated
over conduction and radiation losses for all three receiver
geometries.
Finally, conclusions on favourable flux and temperature profiles
for the reactor tubes studied in this project were drawn. A flux
of at least 2âŻW/cm2 within 100âŻmm of the reactor tube inlet
resulted in higher conversion efficiencies, due to higher
temperatures and reaction rates immediately at the tube inlet
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors. Our goal was to determine if LPA exerts lineage-specific effects during normal human hematopoiesis. In vitro stimulation of CD34+ human hematopoietic progenitors by LPA induced myeloid differentiation but had no effect on lymphoid differentiation. LPA receptors were expressed at significantly higher levels on Common Myeloid Progenitors (CMP) than either multipotent Hematopoietic Stem/Progenitor Cells (HSPC) or Common Lymphoid Progenitors (CLP) suggesting that LPA acts on committed myeloid progenitors. Functional studies demonstrated that LPA enhanced migration, induced cell proliferation and reduced apoptosis of isolated CMP, but had no effect on either HSPC or CLP. Analysis of adult and fetal human bone marrow sections showed that PPAP2A, (the enzyme which degrades LPA) was highly expressed in the osteoblastic niche but not in the perivascular regions, whereas Autotaxin (the enzyme that synthesizes LPA) was expressed in perivascular regions of the marrow. We propose that a gradient of LPA with the highest levels in peri-sinusoidal regions and lowest near the endosteal zone, regulates the localization, proliferation and differentiation of myeloid progenitors within the bone marrow marrow
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