Providence College: An Era of Change, Recollections

Recollections on Providence College History by Mario DiNunzio, Ph.D. ’57, ’22Hon., emeritus professor of histor

The Role of the Superintendent of Schools in the Process of Collective Negotiations as Perceived by Local Bargaining Agents, Boards of Education and Superintendents in Selected School Districts of New Jersey and Eastern Pennsylvania

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Applications of resource mobilization theory (RMT) as a framework for distributive justice in the archives field

This poster explores whether the resource mobilization theory (RMT) of social movements can serve as a tool for pursuing distributive justice in archives; distributive justice referring to the equitable access to resources necessary for sustainability, agency, and autonomy. Findings of this theoretical literature review indicate that social movement theories such as RMT can provide a valuable lens through which archivists may critically re-examine uneven resource distributions across organizational contexts, facilitating solidaric, accountable, and mutually beneficial relationships necessary to achieve transformative social change

"Conditions of possibility" : towards an archival praxis informed by Black feminist anarchism and a critical trans politics

Grassroots and radical archives have increasingly been presented as more socially just alternatives to dominant institutions. This increased recognition is weighted with a set of risks that minoritized memory-workers must navigate. Under the auspices of the gendered, racial-capitalist settler state, dominant institutions will ultimately work to diffuse the potentials of radical memory work and organizing that threatens their hegemony while continuing to profit from this work. In this thesis, I ask, what are we to do—as trans, queers, crips, criminals, whores, dykes, fags and anarchists—who hope to do liberatory memory work while existing in spaces that at best are extracting from us, and at worst, killing us? Can memory work existing under the auspices of the white supremacist settler-state, within these institutions, be truly revolutionary? How can we document our social movement histories, working class resistance, and lawless subversion without replicating the administrative violence, surveillance, and carceral logics of the nation-state? To address these questions, I draw upon my experiential knowledge organizing with the books to prisons collective, Inside Books Project (IBP) over a span of nine years. As a queer-crip, non-binary anarchist and prison abolitionist, my political praxes formed the basis of an archival methodology that enabled me to navigate some of these questions in my capacity as the project archivist for IBP. I argue that frameworks of Black feminist anarchism and critical trans politics can inform an archival praxis that emerges in the interstices of impossible being and becoming embodied by the enslaved, incarcerated, detained, maimed, undocumented, disabled, and disposable. Drawing on the work of Black archivists and anarchists, I will discuss how I have applied these praxes in my work documenting the narratives of incarcerated people in Texas. In doing this, I hope to promote a more sustained engagement with Black feminist anarchism and a critical trans politics in the field of memory work and archives. I also hope to encourage anarchists and others organizing towards collective liberation to more actively engage in memory work as a praxis of disruption, subversion, and radical futurityWomen's and Gender StudiesInformatio

Thermo-kinetic mixing for pharmaceutical applications

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Board of Regents, University of Texas Syste

Insights into the Control of Drug Release from Complex Immediate Release Formulations.

The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process, especially for immediate release tablets. This research employed terahertz pulsed imaging to measure the process of water penetrating through tablets using a flow cell. Tablets were prepared over a range of porosity between 10% to 20%. The formulations consist of two drugs (MK-8408: ruzasvir as a spray dried intermediate, and MK-3682: uprifosbuvir as a crystalline drug substance) and NaCl (0% to 20%) at varying levels of concentrations as well as other excipients. A power-law model is found to fit the liquid penetration exceptionally well (average R2>0.995). For each formulation, the rate of water penetration, extent of swelling and the USP dissolution rate were compared. A factorial analysis then revealed that the tablet porosity was the dominating factor for both liquid penetration and dissolution. NaCl more significantly influenced liquid penetration due to osmotic driving force as well as gelling suppression, but there appears to be little difference when NaCl loading in the formulation increases from 5% to 10%. The level of spray dried intermediate was observed to further limit the release of API in dissolution

Processing-Induced Disorder in Pharmaceutical Materials

This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally. Milling is one of the most frequently used unit operations used by the pharmaceutical industry for reducing the particle size of solids. Thermal processing techniques are mainly used for controlling or improving the release and the subsequent bioavailability of an active pharmaceutical ingredient (API). Techniques such as melt-mixing, spray-congealing, sintering, melt-granulation, and hot-melt extrusion (HME) have developed and evolved rapidly for large-scale pharmaceutical production. Solvent-evaporation-based methods are important processing techniques for both raw materials, such as crystallization of the raw drug, and formulation manufacturing in the pharmaceutical industry. The chapter discusses the processing that can potentially induce the formation of the disordered state during the manufacture of formulations. The widely used solvent-evaporation-based processing techniques in pharmaceutical formulation production include spray-drying, freeze-drying, film casting, and film coating