Differential regulation of Period 2 and Period 3 expression during development of the zebrafish circadian clock

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Cerebral cortex is formed from two different clonal populations of early segregated neuronal progenitors

This article corresponds to n° 1997-016 document of the Molecular Biology of Development Unit’s archives (head Jean-François Nicolas). Written during the second half of 1997, then submitted to Nature in November, and then delayed waiting for more results, it has never been resubmitted to any journal. In the context of an open archive policy, we self-archive here the version that was submitted to publication and reviewed (after a fast formatting ; the PDF of the original typing can be obtained on request).The neocortex neurons underlie our cognitive and perceptual abilities. They are organised into vertical columns and horizontal layers and are thought to originate exclusively from germinative epithelium of the ventricular zone. However, the processes controlling the decision to generate a neuron, their specification and number and the formation of the functional units of the cerebral cortex are still matters of speculation 1. The clonal analysis reported here demonstrates that a group of neurons in the adult neocortex has an origin distinct from other neocortical neurons. Cells of this group disperse extensively in the tangential dimension and contribute to all telencephalic structures. Most likely this population originates outside the neocortical ventricular zone 2 and produces nonpyramidal GABA+ interneurons 3,4. The second clonal population of neocortex neurons originates from stationary precursors that produce radially arrayed neurons 5-9 and, presumably, derive from the germinative epithelium of the ventricular zone 10, 11. We propose that the stationary character of these progenitors is necessary for telencephalic formation. The progenitors of these two clonal populations of neurons are segregated before the onset of cortical neurogenesis. Therefore, neocortex neurons have a double clonal origin and arise from progenitors with distinct modes of migration and specifications. These findings should greatly facilitate further studies and interpretations of telencephalic development

Expression of the orphan nuclear receptor ERRalpha is under circadian regulation in estrogen-responsive tissues

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Interfacial Structure of Toluene at an Ionic Liquid/Vapor Interface: A Molecular Dynamics Simulation Investigation

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Fish and cephalopods monitoring on the Bay of Biscay and Celtic Sea continental shelves

The demersal fish and cephalopod communities of the continental shelves of the Bay of Biscay and the Celtic Sea have been monitored for more than 30 years by the EVHOE series of fisheries surveys. Since 1987, a total of 4247 stations have been sampled in the fall with a GOV bottom trawl in a depth range of 15 to 600 m. The main objective of these surveys is to monitor 22 benthic fish stocks and 10 cephalopods but also to provide a description of the distribution of a total of 250 fish and 50 commercial invertebrate taxa. The dataset (https://doi.org/10.17882/80041) provides abundance and biomass information by station for all observed taxa. Size distributions for a selection of species are also available. These data are part of a larger set of standardized European surveys that provide essential information for monitoring demersal communities in the Northeast Atlantic. We propose here a critical analysis of the dataset especially in terms of the evolution of the sampling effort and strategy as well as the taxonomic precision

N-α-acylation of lysine catalyzed by immobilized aminoacylases from Streptomyces ambofaciens in aqueous medium

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Study of the effect of polyacrylic acid dispersant on magnetite deposits in steam generators conditions

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A specific and unusual nuclear localization signal in the DNA binding domain of the Rev-erb orphan receptors

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The orphan receptor Rev-erb ALPHA gene is a target of the circadian clock pacemaker

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The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs

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