Nitrogen and weed management in transplanted tomato in the Nigerian forest-savanna transition zone

Weed infestation and inherent low soil fertility are among primary reasons for low yields of tomato in Nigeria. Field trials were carried out during the wet season of 2015 and 2016 to evaluate yield response of tomato to nitrogen (N) application and weed control methods in the forest-savanna transition zone of Abeokuta, Nigeria. Positive relationship exists between growth of weed species and increase in N application. Across the years of study, increase in N up to 90 kg/ha increased weed density by 11–25%, however, the increased N gave the transplanted tomato competitive advantage and thus enhanced weed smothering. Pre-transplant application of butachlor (50% w/v) or probaben® (metolachlor 20% w/v+prometryn 20% w/v) each at 2.0 kg a.i/ha followed by supplementary hoe weeding at 6 weeks after transplanting (WAT) significantly reduced weed density by at least 15% and increased fruit yield of tomato by at least 32%, compared to use of the pre-transplant herbicides alone, across both years of study. The greatest tomato fruit yield of 12.2 t/ha was obtained with pre-transplant application of butachlor at 2.0 kg a.i/ha followed by supplementary hoe weeding at 6 WAT, averaged for both years. In general, this study suggests that increased application of N up to 90 kg/ha, and complementary weed control by pre-transplant herbicide and hoe weeding at 6 WAT would improve yield of tomato in the forestsavanna transition zone of Nigeria

INFLUENCE OF INTER-ROW SPACING AND WEED CONTROL METHODS IN GROUNDNUT (Arachis hypogeal (L.)

Weed competition has been identified as one of the major obstacles in crop production. The produc-tion of groundnut is limited by high weed infestation resulting in yield losses ranging from 50 - 80% in Nigeria. Hence, the need to evaluate integrated weed control in its production. Field trials were there-fore conducted at the Teaching and Research Farm of the Federal University of Agriculture, Abeokuta (7o 20’ N, 30 23’ E) to evaluate the influence of inter-row spacing and weed control methods on growth and yield of groundnut during the wet seasons in 2009 and 2010. The experiment was a Randomised Complete Design (RCBD) laid out in a split plot with three replications. The main plot treatment con-sisted of three inter-row spacings of 60 cm, 75 cm and 90 cm while the subplots included five weed control treatments of commercial formulation of metolachlor plus promethyne mixture (codal) at 1.0 kg a.i/ha, codal at 1.0 kg a.i./ha followed by supplementary hoe weeding at 6 weeks after sowing (WAS), codal at 2 kg a.i./ha, hoe weeding at 3, 6 and 9 WAS and a weedy check. Inter-row spacings of 60 cm and 75 cm reduced weed growth with consequent higher yields compared to the inter-row spacings of 90 cm in the early season of 2009. Application of codal at 1.0 kg a.i./ha followed by supplementary hoe weeding at 6 WAS combined with 60cm inter-row spacing gave effective weed control and higher groundnut pod yield than hoe-weeded control in both years of experimentation

DESIGN AND FABRICATION OF COMBINED ELECTROMAGNETIC AND MAGNETIC DRUM-BELT CONVEYOR SEPARATOR

Mineral processing operations are faced with many challenges which include effective separation of unwanted materials generated through the extraction process from the bulk material. Magnetic device is a machine used for separating magnetic materials from non-magnetic materials by inducing the magnetic flux. Magnetic and electromagnetic separators are widely used as primary separation equipment. This work was centred on the design and construction of a laboratory-sized dual purpose magnetic and electromagnetic separator for separating the magnetic particles from the rest of the bulk mineral or ferrous materials from foundry sand in a single system. The main components of the equipment include: the hopper, conveyor belt rotating drums, pulley and belt, electromagnet. The approaches to achieving the result reported include the design conceptualization, design calculation, design drawing using the AutoCAD and Inventor software, fabrication and assembly of components. The evaluation showed that electromagnetic separation is more efficient than magnetic separation. The equipment was fabricated at an average cost of 224,000:00 naira

Carbon ion therapy for ameloblastic carcinoma

Ameloblastic carcinomas are rare odontogenic tumors. Treatment usually consists of surgical resection and sometimes adjuvant radiation. We report the case of a 71 year-old male patient undergoing carbon ion therapy for extensive local relapse of ameloblastic carcinoma. Treatment outcome was favourable with a complete remission at 6 weeks post completion of radiotherapy while RT-treatment itself was tolerated well with only mild side effects. High dose radiation hence is a potential alternative for patients unfit or unwilling to undergo extensive surgery or in cases when only a subtotal resection is planned or the resection is mutilating

Anti-trypanosomal Activity of Bufonidae (Toad) Venom Crude Extract on Trypanosoma brucei brucei in Swiss Mice

Trypanosomiasis afflicts about 6 ~ 7 million people globally and to a large extent impedes livestock production in Africa. Naturally, trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of therapies. The utilization of animals and plants products has presented therapeutic potential for identifying novel anti-trypanosomal drugs. This study evaluated toad venom for anti-trypanosomal potency invivo in Swiss mice. Toads were collected from July to August 2019. The acute oral toxicity and biochemical characterization of the toad venom were determined. The experimental mice were administered various doses (130 mg/kg, 173 mg/kg and 217 mg/kg) of the toad venom crude extract and 0.75 mg/mL of Diamizan Plus standard drug for the treatment of trypanosomiasis, once daily for 3 days. The in-vivo anti-trypanosomal activity was evaluated by a curative test, after infecting the mice with Trypanosoma brucei brucei. The pre-patent period was 72 hours before treatment commenced. The overall results showed that trypanosomal load was highest in the control group while the group treated with Diamizan drug had the least trypanosomal load. As such, the mean trypanosomal load in relation to treatments showed a very high significant difference (P0.05) across treatment groups. The over 50% reduction in the trypanosomal load in the 130 mg/kg group in comparison with the control group brings to bare the anti-trypanosomal potency of the toad venom. The anti-trypanosomal activity demonstrated by the toad venom has provided basis for development of new therapeutic agents from different toad species. The study recommends further studies (both in-vivo and invitro) followed by the characterization of the active compounds present in the toad venom responsible for the anti-tyrpanosomal activity observed alongside the management and conservation of these species

Head & Neck Oncology: purpose, scope and goals-charting the future

For many years now there has been a growing frustration with the statistics of head and neck cancer. Despite the many advances in diagnosis and therapy, there has been little change in the prognosis for most cancers of the head and neck in the last 50 years, so what is the point of yet another journal? Well, it is not all bad news

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

Uncontrolled self-association is a major challenge in the exploitation of proteins as therapeutics. Here we describe the development of a structural proteomics approach to identify the amino acids responsible for aberrant self-association of monoclonal antibodies and the design of a variant with reduced aggregation and increased serum persistence in vivo. We show that the human monoclonal antibody, MEDI1912, selected against nerve growth factor binds with picomolar affinity, but undergoes reversible self-association and has a poor pharmacokinetic profile in both rat and cynomolgus monkeys. Using hydrogen/deuterium exchange and cross-linking-mass spectrometry we map the residues responsible for self-association of MEDI1912 and show that disruption of the self-interaction interface by three mutations enhances its biophysical properties and serum persistence, whilst maintaining high affinity and potency. Immunohistochemistry suggests that this is achieved via reduction of non-specific tissue binding. The strategy developed represents a powerful and generic approach to improve the properties of therapeutic proteins

Multimeric single-domain antibody complexes protect against bunyavirus infections

The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a broadly applicable strategy, based on llama-derived single-domain antibodies (VHHs), for the development of bunyavirus biotherapeutics. The method was validated using the zoonotic Rift Valley fever virus (RVFV) and Schmallenberg virus (SBV), an emerging pathogen of ruminants, as model pathogens. VHH building blocks were assembled into highly potent neutralizing complexes using bacterial superglue technology. The multimeric complexes were shown to reduce and prevent virus-induced morbidity and mortality in mice upon prophylactic administration. Bispecific molecules engineered to present two different VHHs fused to an Fc domain were further shown to be effective upon therapeutic administration. The presented VHH-based technology holds great promise for the development of bunyavirus antiviral therapies

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS