The galactic magnetic field in the quasar 3C216

Multifrequency polarimetric observations made with the Very Long Baseline Array of the quasar 3C216 reveal the presence of Faraday rotation measures (RMs) in excess of 2000 rad/m**2 in the source rest frame, in the arc of emission located at ~ 140 mas from the core. Rotation measures in the range -300 - +300 rad/m**2 are detected in the inner 5 mas (~30 parsecs). while the rotation measures near the core can be explained as due to a magnetic field in the narrow line region, we favor the interpretation for the high RM in the arc as due to a ``local'' Faraday screen, produced in a shock where the jet is deflected by the interstellar medium of the host galaxy. Our results indicate that a galacit magnetic field of the order of 50 microGauss on a scale greater than 100 pc must be present in the galactic medium.Comment: 23 pages, 3 tables, 11 figures. To appear on The Astronomical Journal, November 1999 Issu

Radio Loud and Radio Quiet Active Galactic Nuclei

We generated a sample of 409 AGNs for which both the radio luminosity at 5 GHz and the line luminosity in [OIII] 5007 have been measured. The radio luminosity spans a range of ten orders of magnitude, and the [OIII] line luminosity spans a range of eight orders of magnitude --- both considerably larger than the ranges in previous studies. We show that these two quantities are correlated in a similar way for both radio-loud and radio-quiet AGNs. We demonstrate that the observed correlation can be explained in terms of a model in which jets are accelerated and collimated by a vertical magnetic field.Comment: 45 pages inc. 7 figures, 1 table of 15 pages in ps-format. Accept to AJ September 199

Radio polarimetric imaging of the interstellar medium: magnetic field and diffuse ionized gas structure near the W3/W4/W5/HB3 complex

We have used polarimetric imaging to study the magneto-ionic medium of the Galaxy, obtaining 1420 MHz images with an angular resolution of 1' over more than 40 square-degrees of sky around the W3/W4/W5/HB3 HII region/SNR complex in the Perseus Arm. Features detected in polarization angle are imposed on the linearly polarized Galactic synchrotron background emission by Faraday rotation arising in foreground ionized gas having an emission measure as low as 1 cm^{-6} pc. Several new remarkable phenomena have been identified, including: mottled polarization arising from random fluctuations in a magneto-ionic screen that we identify with a medium in the Perseus Arm, probably in the vicinity of the HII regions themselves; depolarization arising from very high rotation measures (several times 10^3 rad m^{-2}) and rotation measure gradients due to the dense, turbulent environs of the HII regions; highly ordered features spanning up to several degrees; and an extended influence of the HII regions beyond the boundaries defined by earlier observations. In particular, the effects of an extended, low-density ionized halo around the HII region W4 are evident, probably an example of the extended HII envelopes postulated as the origin of weak recombination-line emission detected from the Galactic ridge. Our polarization observations can be understood if the uniform magnetic field component in this envelope scales with the square-root of electron density and is 20 microG at the edge of the depolarized region around W4, although this is probably an over-estimate since the random field component will have a significant effect.Comment: 18 pages, 8 figures (7 jpeg and 1 postscript), accepted for publication in the Astrophysical Journa

A Conserved PHD Finger Protein and Endogenous RNAi Modulate Insulin Signaling in Caenorhabditis elegans

Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA interference factor RDE-4 and conserved PHD zinc finger protein ZFP-1 (AF10), which regulate overlapping sets of genes in Caenorhabditis elegans, we identified an important role for these factors in the negative modulation of transcription of the insulin/PI3 signaling-dependent kinase PDK-1. Consistently, increased expression of pdk-1 in zfp-1 and rde-4 mutants contributed to their reduced lifespan and sensitivity to oxidative stress and pathogens due to the reduction in the expression of DAF-16 and SKN-1 targets. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant, since the lifespan of the age-1; zfp-1 double mutant strain was significantly shorter compared to age-1(hx546). We further demonstrate that overexpression of ZFP-1 caused an increased resistance to oxidative stress in a DAF-16–dependent manner. Our findings suggest that epigenetic regulation of key upstream signaling components in signal transduction pathways through chromatin and RNAi may have a large impact on the outcome of signaling and expression of numerous downstream genes.Leukemia & Lymphoma Society of America (3260-07 Special Fellow Award)Arnold and Mabel Beckman Foundation (Young Investigator Award)United States. National Institutes of Health (Director's New Innovator Award (1 DP2 OD006412-01))United States. National Institutes of Health (grant GM66269)modENCODE (grant U01 HG004270)United States. National Institutes of Health (training grant 5T32 GM07088-34

Milestones in the Observations of Cosmic Magnetic Fields

Magnetic fields are observed everywhere in the universe. In this review, we concentrate on the observational aspects of the magnetic fields of Galactic and extragalactic objects. Readers can follow the milestones in the observations of cosmic magnetic fields obtained from the most important tracers of magnetic fields, namely, the star-light polarization, the Zeeman effect, the rotation measures (RMs, hereafter) of extragalactic radio sources, the pulsar RMs, radio polarization observations, as well as the newly implemented sub-mm and mm polarization capabilities. (Another long paragraph is omitted due to the limited space here)Comment: Invited Review (ChJA&A); 32 pages. Sorry if your significant contributions in this area were not mentioned. Published pdf & ps files (with high quality figures) now availble at http://www.chjaa.org/2002_2_4.ht

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexit

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation

Love under lockdown: The lived experiences of cohabitation couples during the COVID-19 pandemic

Abstract onlyTh e focus of this study will be on the relationship of cohabitation couples during the COVID-19 Pandemic in terms of their reasons for cohabitation, their experiences during the pandemic, and their management of challenges in their relationships. A qualitative study is used. A phenomenological approach is used to gather detailed accounts of the experiences of the selected cohabitation couples. Th e researchers will employ the purposive sampling technique to identify and select the participants. The participants' stories as transcribed from the interviews were used to generate themes in accordance to their experiences as cohabitation couples during the C O V ID -19 Pandemic. Participants are free to relate their experiences without restraint and emanate from their subjective opinions as they may all hold distinct viewpoints on the truth. Based on the participants' responses on their reasons for cohabitation, it was discovered that love and mutual understanding are the main driving forces for them to cohabitate. Financial instability was the most common struggle the participants experienced during the pandemic. It was also found that in times of unavoidable conflicts and misunderstandings, choosing to understand each other is integral. In terms of managing and overcoming difficulties and working through challenges in their relationship, helping and supporting each other is a necessity. Th e foundation of an enduring and meaningful relationship lies in facing, communicating, and solving conflicts and difficulties as partners. Compromising in order to understand your partner's needs causes relational cultivation and would help to build a healthy relationship.Bachelor of Science in Psycholog

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms