Rodenticide residues in non-target small mammal species and their occurrence in owl pellets

OBJECTIVES: Distinguishing the patterns of autoantibodies (AAB) against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon and the discovery of such a pattern in patients who are as yet asymptomatic could help to identify patients at high risk of developing the life-threatening complications of Chagas' disease. BACKGROUND: Such AAB against receptors as beta 1 (beta1-AAB), beta 2 (beta2-AAB), and muscarinergic 2 (M2-AAB) are thought to be involved in the pathogenesis of Chagas' cardiomyopathy and megacolon, the predominant manifestations of Chagas' disease, which is the most serious parasitic disease in Latin America. METHODS: Beta1-AAB, beta2-AAB, and M2-AAB were measured in the serum of asymptomatic Chagas' patients and in those with cardiomyopathy and/or megacolon. RESULTS: Nearly all Chagas' patients with cardiomyopathy and/or megacolon had AAB. Predominance of beta1-AAB combined with M2-AAB in Chagas' cardiomyopathy and beta2-AAB with M2-AAB in megacolon was found. Such patterns were also found in 34% of the asymptomatic patients, of whom 85% possessed a beta1-AAB level typical for Chagas' cardiomyopathy. CONCLUSIONS: The percentage of asymptomatic Chagas' patients who had a specific AAB pattern and had a beta1-AAB level above a defined cutoff point mirrors very well the epidemiological situation, which showed that clinical manifestations develop in nearly 30% of Chagas' patients and cardiomyopathy in nearly 90% of them. We hypothesize that beta1-, beta2-, and M2-AAB measurement might be a useful tool for risk assessment in the indeterminate state of Chagas' disease to select patients for earlier involvement in care programs. However, prospective studies are needed to further evaluate this hypothesis

Analysis of coal conversion to biomass as a transitional technology

The dominant transitional path towards a low carbon electricity industry for systems which have been heavily dependent upon coal is through its replacement by large scale wind farms and the widespread emergence of distributed solar. In this pathway, maintaining resource adequacy in the context of increased intermittency in generation has become a major concern. This paper examines this requirement to maintain resource adequacy and compare the costs and carbon impacts for new gas turbines or biomass conversions to achieve this in an expedient transitional way. This is formulated as a policy optimization in which the imperative is to replace existing coal with a renewable alternative (in this case study, wind) and to maintain the system security at the existing level, and thereby find the optimal subsidies, either as energy credits ("green certificates" or “contracts-for-differences”) or capital benefits ("capacity payments" or tax allowances). In a model of the GB system, the results show that that biomass-conversion outperforms investment in peaking gas turbines to deal with the transitional economic externality of extra reserve costs. In particular, the results suggest benefits of 10% lower costs of subsidies, 70% lower implied costs of carbon, and a reduction of 18% in wholesale power prices

Consideration of the bioavailability of metal/metalloid species in freshwaters: experiences regarding the implementation of biotic ligand model-based approaches in risk assessment frameworks

After the scientific development of Biotic Ligand Models (BLMs) in recent decades these models are now considered suitable for implementation in regulatory risk assessment of metals in freshwater bodies. The approach has been developed over several years and has been described in many peer-reviewed publications. The original complex BLMs have been applied in prospective risk assessment reports for metals and metal compounds and are also recommended as suitable concepts for the evaluation of monitoring data in the context of the European Water Framework Directive. Currently, several user-friendly BLM-based bioavailability software tools are available for assessing the aquatic toxicity of a limited number of metals (mainly copper, nickel, and zinc). These tools need only a basic set of water parameters as input (e.g., pH, hardness, dissolved organic matter and dissolved metal concentration). Such tools seem appropriate to foster the implementation in routine water quality assessments. This work aims to review the existing bioavailability-based regulatory approaches and the application of available BLM-based bioavailability tools for this purpose. Advantages and possible drawbacks of these tools (e.g., feasibility, boundaries of validity) are discussed, and recommendations for further implementation are given

Spectrophotometric Observations of Blue Compact Dwarf Galaxies: Mrk 370

We present results from a detailed spectrophotometric analysis of the blue compact dwarf galaxy (BCD) Mrk 370, based on deep UBVRI broad-band and Halpha narrow-band observations, and long-slit and two-dimensional spectroscopy of its brightest knots. The spectroscopic data are used to derive the internal extinction, and to compute metallicities, electronic density and temperature in the knots. By subtracting the contribution of the underlying older stellar population, modeled by an exponential function, removing the contribution from emission lines, and correcting for extinction, we can measure the true colors of the young star-forming knots. We show that the colors obtained this way differ significantly from those derived without the above corrections, and lead to different estimates of the ages and star-forming history of the knots. Using predictions of evolutionary synthesis models, we estimate the ages of both the starburst regions and the underlying stellar component. We found that we can reproduce the colors of all the knots with an instantaneous burst of star formation and the Salpeter initial mass function with an upper mass limit of 100 solar masses. The resulting ages range between 3 and 6 Myrs. The colors of the low surface brightness component are consistent with ages larger than 5 Gyr. The kinematic results suggest ordered motion around the major axis of the galaxy.Comment: 26 pages with 14 figures; accepted for publication in Ap

A Herschel/PACS Far Infrared Line Emission Survey of Local Luminous Infrared Galaxies

We present an analysis of [OI]63, [OIII]88, [NII]122 and [CII]158 far-infrared (FIR) fine-structure line observations obtained with Herschel/PACS, for ~240 local luminous infrared galaxies (LIRGs) in the Great Observatories All-sky LIRG Survey (GOALS). We find pronounced declines -deficits- of line-to-FIR-continuum emission for [NII]122, [OI]63 and [CII]158 as a function of FIR color and infrared luminosity surface density, $\Sigma_{\rm IR}$. The median electron density of the ionized gas in LIRGs, based on the [NII]122/[NII]205 ratio, is $n_{\rm e}$ = 41 cm$^{-3}$. We find that the dispersion in the [CII]158 deficit of LIRGs is attributed to a varying fractional contribution of photo-dissociation-regions (PDRs) to the observed [CII]158 emission, f([CII]PDR) = [CII]PDR/[CII], which increases from ~60% to ~95% in the warmest LIRGs. The [OI]63/[CII]158PDR ratio is tightly correlated with the PDR gas kinetic temperature in sources where [OI]63 is not optically-thick or self-absorbed. For each galaxy, we derive the average PDR hydrogen density, $n_{\rm H}$, and intensity of the interstellar radiation field, in units of G$_0$, and find G$_0$/$n_{\rm H}$ ratios ~0.1-50 cm$^3$, with ULIRGs populating the upper end of the distribution. There is a relation between G$_0$/$n_{\rm H}$ and $\Sigma_{\rm IR}$, showing a critical break at $\Sigma_{\rm IR}^{\star}$ ~ 5 x 10$^{10}$ Lsun/kpc$^2$. Below $\Sigma_{\rm IR}^{\star}$, G$_0$/$n_{\rm H}$ remains constant, ~0.32 cm$^3$, and variations in $\Sigma_{\rm IR}$ are driven by the number density of star-forming regions within a galaxy, with no change in their PDR properties. Above $\Sigma_{\rm IR}^{\star}$, G$_0$/$n_{\rm H}$ increases rapidly with $\Sigma_{\rm IR}$, signaling a departure from the typical PDR conditions found in normal star-forming galaxies towards more intense/harder radiation fields and compact geometries typical of starbursting sources.Comment: 23 pages, 12 figures. Submitted to ApJ, including 2nd round of referee comments. Data tables can be found at: http://goals.ipac.caltech.edu/ and will also appear on the electronic version of the journa

Higgs and Z boson decays into light gluinos

We calculate the decay rate of scalar and pseudoscalar Higgs bosons into a pair of gluinos, within the Minimal Supersymmetric Standard Model. In the theoretically and experimentally allowed light gluino window, \mg \sim 3--5 GeV, gluino pairs can completely dominate the decays of the light scalar Higgs boson and play a prominent role in the decay of the pseudoscalar Higgs boson. This would alter the limits obtained from $Z$ decays on the lightest CP--even and CP--odd Higgs bosons, and could jeopardize the search for these Higgs particles at future hadron colliders. In contrast, the branching ratio for the two--body decay of $Z$ bosons into pairs of light gluinos is less than 0.1\%.Comment: Latex file, 16 pages of text. 8 uufiled postscript figures included. Compressed postscript version with figures available by anonymous ftp at ftp://phenom.physics.wisc.edu/pub/preprints/current/madph-94-853.ps.

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk], AJPB (BB/F00513X/1, BB/K017365/1); the CNPq-Brazil [http://cnpq.br], GMA (Science without Borders fellowship 202976/2014-9); and the National Centre for the Replacement, Refinement and Reduction of Animals in Research [www.nc3rs.org.uk], DMM (NC/K000306/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We thank Dr. Elizabeth Johnson (Mycology Reference Laboratory, Bristol) for providing strains, and the Aberdeen Proteomics facility for the biotyping of S. cerevisiae clinical isolates, and to Euroscarf for providing S. cerevisiae strains and plasmids. We are grateful to our Microscopy Facility in the Institute of Medical Sciences for their expert help with the electron microscopy, and to our friends in the Aberdeen Fungal Group for insightful discussions.Peer reviewedPublisher PD