Determination of Nonlinear Genetic Architecture using Compressed Sensing

We introduce a statistical method that can reconstruct nonlinear genetic models (i.e., including epistasis, or gene-gene interactions) from phenotype-genotype (GWAS) data. The computational and data resource requirements are similar to those necessary for reconstruction of linear genetic models (or identification of gene-trait associations), assuming a condition of generalized sparsity, which limits the total number of gene-gene interactions. An example of a sparse nonlinear model is one in which a typical locus interacts with several or even many others, but only a small subset of all possible interactions exist. It seems plausible that most genetic architectures fall in this category. Our method uses a generalization of compressed sensing (L1-penalized regression) applied to nonlinear functions of the sensing matrix. We give theoretical arguments suggesting that the method is nearly optimal in performance, and demonstrate its effectiveness on broad classes of nonlinear genetic models using both real and simulated human genomes.Comment: 20 pages, 8 figures. arXiv admin note: text overlap with arXiv:1408.342

Does the BICEP2 Observation of Cosmological Tensor Modes Imply an Era of Nearly Planckian Energy Densities?

BICEP2 observations, interpreted most simply, suggest an era of inflation with energy densities of order ($10^{16}\, {\rm GeV})^4$, not far below the Planck density. However, models of TeV gravity with large extra dimensions might allow a very different interpretation involving much more modest energy scales. We discuss the viability of inflation in such models, and conclude that existing scenarios do not provide attractive alternatives to single field inflation in four dimensions. Because the detection of tensor modes strengthens our confidence that inflation occurred, it disfavors models of large extra dimensions, at least for the moment.Comment: 4 pages, v3: version to appear in JHE

Instability of Quantum de Sitter Spacetime

Quantized fields (e.g., the graviton itself) in de Sitter (dS) spacetime lead to particle production: specifically, we consider a thermal spectrum resulting from the dS (horizon) temperature. The energy required to excite these particles reduces slightly the rate of expansion and eventually modifies the semiclassical spacetime geometry. The resulting manifold no longer has constant curvature nor time reversal invariance, and back-reaction renders the classical dS background unstable to perturbations. In the case of AdS, there exists a global static vacuum state; in this state there is no particle production and the analogous instability does not arise.Comment: 3 pages, v2: version to appear in JHE

Eddy intrustion of hot plasma into the polar cap and formation of polar-cap arcs

Under the simple postulate that multiple large scale detachable magnetospheric convection eddies can exist in the vicinity of the convection reversal boundary and in the polar cap, by Kelvin-Helmholtz instability or otherwise, it is shown that a number of seemingly disconnected plasma and electric field observations in the polar cap can be organized into a theory of magnetosheath and plasmasheet plasma intrusion into the polar cap. Current theory of inverted V structures then predicts existence of similar, but weaker, structures at the eddy convection reversal boundaries in the polar cap. A possible consequence is that the polar cap auroras are natural offshoots from discrete oval arcs and evidently are formed by similar processes. The two arc systems can occassionally produce an optical image in the form of the theta aurora

Radiative Corrections to Longitudinal and Transverse Gauge Boson and Higgs Production

Radiative corrections to gauge boson and Higgs production computed recently using soft-collinear effective theory (SCET) require the one-loop high-scale matching coefficients in the standard model. We give explicit expressions for the matching coefficients for the effective field theory (EFT) operators for q qbar -> VV and q qbar -> phi^+ phi for a general gauge theory with an arbitrary number of gauge groups. The group theory factors are given explicitly for the standard model, including both QCD and electroweak corrections.Comment: 16 pages, 49 figure

Statistical Modelling of Information Sharing: Community, Membership and Content

File-sharing systems, like many online and traditional information sharing communities (e.g. newsgroups, BBS, forums, interest clubs), are dynamical systems in nature. As peers get in and out of the system, the information content made available by the prevailing membership varies continually in amount as well as composition, which in turn affects all peers' join/leave decisions. As a result, the dynamics of membership and information content are strongly coupled, suggesting interesting issues about growth, sustenance and stability. In this paper, we propose to study such communities with a simple statistical model of an information sharing club. Carrying their private payloads of information goods as potential supply to the club, peers join or leave on the basis of whether the information they demand is currently available. Information goods are chunked and typed, as in a file sharing system where peers contribute different files, or a forum where messages are grouped by topics or threads. Peers' demand and supply are then characterized by statistical distributions over the type domain. This model reveals interesting critical behaviour with multiple equilibria. A sharp growth threshold is derived: the club may grow towards a sustainable equilibrium only if the value of an order parameter is above the threshold, or shrink to emptiness otherwise. The order parameter is composite and comprises the peer population size, the level of their contributed supply, the club's efficiency in information search, the spread of supply and demand over the type domain, as well as the goodness of match between them.Comment: accepted in International Symposium on Computer Performance, Modeling, Measurements and Evaluation, Juan-les-Pins, France, October-200