Thirty Years of Radio Observations of Type Ia SN 1972E and SN 1895B: Constraints on Circumstellar Shells

We have imaged over 35 years of archival Very Large Array (VLA) observations of the nearby (d$_{\rm{L}}$ $=$ 3.15 Mpc) Type Ia supernovae SN\,1972E and SN\,1895B between 9 and 121 years post-explosion. No radio emission is detected, constraining the 8.5 GHz luminosities of SN\,1972E and SN\,1895B to be L$_{\nu,8.5\rm{GHz}}$ $<$ 6.0 $\times$ 10$^{23}$ erg s$^{-1}$ Hz$^{-1}$ 45 years post-explosion and L$_{\nu,8.5\rm{GHz}}$ $<$ 8.9 $\times$ 10$^{23}$ erg s$^{-1}$ Hz$^{-1}$ 121 years post-explosion, respectively. These limits imply a clean circumstellar medium (CSM), with $n$ $<$ 0.9 cm$^{-3}$ out to radii of a few $\times$ 10$^{18}$ cm, if the SN blastwave is expanding into uniform density material. Due to the extensive time coverage of our observations, we also constrain the presence of CSM shells surrounding the progenitor of SN\,1972E. We rule out essentially all medium and thick shells with masses of 0.05$-$0.3 M$_\odot$ at radii between $\sim$10$^{17}$ and 10$^{18}$ cm, and thin shells at specific radii with masses down to $\lesssim$0.01 M$_\odot$. These constraints rule out swaths of parameter space for a range of single and double degenerate progenitor scenarios, including recurrent nova, core-degenerate objects, ultra-prompt explosions and white dwarf (WD) mergers with delays of a few hundred years between the onset of merger and explosion. Allowed progenitors include WD-WD systems with a significant ($>$ 10$^{4}$ years) delay from the last episode of common envelope evolution and single degenerate systems undergoing recurrent nova, provided that the recurrence timescale i short and the system has been in the nova phase for $\gtrsim$10$^{4}$ yr, such that a large ($>$ 10$^{18}$ cm) cavity has been evacuated. Future multi-epoch observations of additional intermediate-aged Type Ia SNe will provide a comprehensive view of the large-scale CSM environments around these explosions.Comment: Accepted for publication in the Astrophysical Journa

The Re-Acceleration of the Shock Wave in the Radio Remnant of SN 1987A

We report on updated radio imaging observations of the radio remnant of Supernova 1987A (SN 1987A) at 9 GHz, taken with the Australia Telescope Compact Array (ATCA), covering a 25-year period (1992-2017). We use Fourier modeling of the supernova remnant to model its morphology, using both a torus model and a ring model, and find both models show an increasing flux density, and have shown a continuing expansion of the remnant. As found in previous studies, we find the torus model most accurately fits our data, and has shown a change in the remnant expansion at Day 9,300 $\pm$210 from 2,300 $\pm$200 km/s to 3,610 $\pm$240 km/s. We have also seen an increase in brightness in the western lobe of the remnant, although the eastern lobe is still the dominant source of emission, unlike what has been observed at contemporary optical and X-ray wavelengths. We expect to observe a reversal in this asymmetry by the year $\sim$2020, and note the south-eastern side of the remnant is now beginning to fade, as has also been seen in optical and X-ray data. Our data indicate that high-latitude emission has been present in the remnant from the earliest stages of the shockwave interacting with the equatorial ring around Day 5,000. However, we find the emission has become increasingly dominated by the low-lying regions by Day 9,300, overlapping with the regions of X-ray emission. We conclude that the shockwave is now leaving the equatorial ring, exiting first from the south-east region of the remnant, and is re-accelerating as it begins to interact with the circumstellar medium beyond the dense inner ring.Comment: 22 pages, 14 figures. Accepted to Ap

Формування маркетингових підрозділів на підприємствах Харківського регіону

У статті розглянуто ситуацію формування маркетингових підрозділів на підприємствах Харківського регіону, розвиток їх структури, проаналізовано підходи до формування кадрового складу маркетингових підрозділів та динаміку їх розвитку, визначені тенденції щодо подальших напрямків вдосконалення маркетингу та виявлені ніші для перспективного розвитку маркетингу у Харківському регіоні.The article deals with the situation forming marketing departments in enterprises of Kharkov region, the development of structure analysis approaches to staffing marketing departments and the dynamics of their development trends identified areas for further improvement of marketing and found a niche for the future of marketing in the Kharkiv region

Demonstration project on epilepsy in Brazil - Outcome assessment

Purpose: To assess the outcome of patients with epilepsy treated at primary care health units under the framework of the demonstration project on epilepsy in Brazil, part of the WHO/ILAE/IBE Global Campaign Against Epilepsy. Method. We assessed the outcome of patients treated at four primary health units. The staff of the health units underwent information training in epilepsy. The outcome assessment was based on: 1) reduction of seizure frequency, 2) subjective perception from the patient's and the physician's point of view, 3) reduction of absenteeism, 4) social integration (school and work), and 5) sense of independence. Results: A total of 181 patients (93 women - 51%) with a mean age of 38 (range from 2 to 86) years were studied. The mean follow-up was 26 months (range from 1 to 38 months, 11 patients had follow-up of less than 12 months). Seizure frequency was assessed based on a score system, ranging from 0 (no seizure in the previous 24 months) to 7 (> 10 seizure/day). The baseline median seizure-frequency score was 3 (one to three seizures per month). At the end of the study the median seizure-frequency score was 1 (one to three seizures per year). The patients' and relatives' opinions were that in the majority (59%) the health status had improved a lot, some (19%) had improved a little, 20% experienced no change and in 2% the health status was worse. With regard to absenteeism, social integration and sense of independence, there were some modest improvements only. Discussion: The development of a model of epilepsy treatment at primary health level based on the existing health system, with strategic measures centred on the health care providers and the community, has proved to be effective providing important reductions in seizure frequency, as well as in general well being. This model can be applied nationwide, as the key elements already exist provided that strategic measures are put forward in accordance with local health providers and managers

Hierarchic finite element bases on unstructured tetrahedral meshes

The problem of constructing hierarchic bases for finite element discretization of the spaces H1, H(curl), H(div) and L2 on tetrahedral elements is addressed. A simple and efficient approach to ensuring conformity of the approximations across element interfaces is described. Hierarchic bases of arbitrary polynomial order are presented. It is shown how these may be used to construct finite element approximations of arbitrary, non-uniform, local order approximation on unstructured meshes of curvilinear tetrahedral elements

Distúrbio do processamento auditivo em gemelares com polimicrogiria perisylviana

Made available in DSpace on 2013-08-12T18:12:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-01Made available in DSpace on 2013-09-30T19:15:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-01Submitted by Vitor Silverio Rodrigues ([email protected]) on 2014-05-20T15:31:41Z No. of bitstreams: 0Made available in DSpace on 2014-05-20T15:31:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-01Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Neurol, Campinas, SP, BrazilState Univ São Paulo Julio de Mesquita Filho, Botucatu Med Sch, Interact Univ Serv & Community Program, São Paulo, BrazilUniv São Paulo, Dept Speech Therapy, Bauru, SP, BrazilState Univ São Paulo Julio de Mesquita Filho, Botucatu Med Sch, Interact Univ Serv & Community Program, São Paulo, Brazi

Interleukin-1beta contributes to the generation of experimental febrile seizures.

Fever can provoke "febrile" seizures (FS). Because complex FS may promote development of temporal lobe epilepsy, understanding their mechanisms is clinically important. Using an immature rodent model and transgenic technology, we examined the role of interleukin-1beta, (IL-1beta), a pyrogenic, proinflammatory cytokine, in FS. IL-1beta receptor-deficient mice were resistant to experimental FS. This resistance appeared independent of genetic background and was attributed to lack of IL-1beta signaling, because exogenous cytokine reduced seizure threshold in wild-type but not receptor-deficient mice independent of strain. In addition, high IL-1beta doses induced seizures only in IL-1beta receptor-expressing mice. These data indicate that IL-1beta signaling contributes critically to fever-induced hyperexcitability underlying FS, constituting a potential target for their prevention

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype

Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical HD phenotype without the expected mutation. The objective of this study was to assess the occurrence of diseases such as Huntington’s disease-like 2 (HDL2), spinocerebellar ataxia (SCA) 1, SCA2, SCA3, SCA7, dentatorubral-pallidoluysian atrophy (DRPLA) and choreaacanthocytosis (ChAc) among 29 Brazilian patients with a HD-like phenotype. In the group analyzed, we found 3 patients with HDL2 and 2 patients with ChAc. The diagnosis was not reached in 79.3% of the patients. HDL2 was the main cause of the HD-like phenotype in the group analyzed, and is attributable to the African ancestry of this population. However, the etiology of the disease remains undetermined in the majority of the HD negative patients with HD-like phenotype. Key words: Huntington’s disease, Huntington’s disease-like, chorea-acanthocytosis, Huntington’s disease-like 2

The il1β have a protective action in the acute phase of the pilocarpine-induced epilepsy model

INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. METHODS: We used RNA interference in order to achieve gene silencing. RESULTS: We obtained significant gene silencing in the central nervous system. In addition, we observed phenotypic effects including differences in mortality rates of animals 5 days after pilocarpine injections. CONCLUSION: Our results indicate that il1β seems to have a protective effect in the acute phase of the pilocarpine-induced epilepsy model.INTRODUÇÃO: Existem contradições na literatura quanto aos efeitos dos genes il1β e il1rn nas epilepsias. Nosso objetivo foi avaliar os efeitos do silenciamento desses dois genes na fase aguda do modelo de epilepsia induzido pela pilocarpina. MÉTODOS: Para alterar a expressão dos genes il1β e il1rn utilizamos a técnica de interferência por RNA. RESULTADOS: Obtivemos taxas de silenciamento significativas para os dois genes no sistema nervoso central. Observamos efeitos fenotípicos significativos, incluindo a alteração na taxa de mortalidade dos animais 5 dias após a indução do modelo. CONCLUSÕES: A il1β parece exercer um papel protetor na fase aguda do modelo de epilepsia induzido pela pilocarpina.UNICAMP FCM Departamento de Genética MedicaUSP Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Departamento de BiologiaUNICAMP Centro Multidisciplinar de Investigação BiológicaUSP IFSC Departamento de Física e BioinformáticaUNIFESP-EPM Departamento de FisiologiaUNIFESP-EPM Departamento de Neurologia e NeurocirurgiaUNICAMP FCM Departamento de Clínica MédicaUNICAMP FCM Departamento de NeurologiaUNIFESP, EPM, Depto. de FisiologiaUNIFESP, EPM Depto. de Neurologia e NeurocirurgiaSciEL

Characterization of the linguistic profile of a family with Perisylvian Syndrome

BACKGROUND: perisylvian syndrome refers to a variety of clinical manifestations associated to lesions in the perisylvian or opercular regions. Polymicrogyria is the most common structural malformation found. The syndrome may be inherited and the clinical spectrum includes subtle language disturbances on one end and more severe characteristics such as prominent pseudobulbar signs and refractory epilepsy on the other end. Other studies have already associated perisylvian polymicrogyria with developmental language disorders or specific language impairment. AIM: to describe the language deficits of four members of a family with Perisylvian Syndrome, and to correlate these deficits to neuroimaging data METHOD: the patients underwent neuroimaging investigation, psychological assessment using the Weschler Intelligence Scales, and specific speech-language evaluation. The following tests were used for the assessment of vocabulary, phonology, syntax, pragmatics, reading and writing: Thematical Pictures of Yavas, ABFW - Child Language Test, Peabody Picture Vocabulary Test (PPVT), and other specific protocols. RESULTS: magnetic resonance imaging revealed perisylvian polymicrogyria in all of the subjects, with varied locations and extensions. Speech-language assessment indicated significant oral and written language deficits in all of the subjects. CONCLUSION: the obtained data indicate that language impairment can co-exist with reading deficits in members of the same family. Neuroimaging findings reveal cortical alterations that are associated to specific language impairments within the spectrum of the Perisylvian Syndrome. Another important aspect evidenced by this study is the similarities in the language profiles of siblings and mother, suggesting that a variety of linguistic manifestations exist within the spectrum of the syndrome. Perisylvian polymicrogyria can be one of the neurobiological malformations involved in the manifestation of these deficits.TEMA: por Síndrome Perisylviana entende-se toda e qualquer manifestação clínica decorrente de lesão ou malformação que comprometa a região da fissura de Sylvius, sendo a polimicrogiria a alteração estrutural mais encontrada. A referida síndrome pode ser familiar, sendo que o espectro clínico pode variar desde manifestações leves de distúrbio de linguagem, até quadros extensos que cursam com proeminentes sinais pseudobulbares e epilepsia refratária. Estudos já correlacionaram a polimicrogiria perisylviana com a ocorrência do Distúrbio Específico de Linguagem. OBJETIVO: o objetivo desse trabalho foi descrever as alterações de linguagem em quatro membros de uma família com Síndrome Perisylviana, e relacioná-las a exames de neuroimagem. MÉTODO: os sujeitos foram submetidos a exames de ressonância magnética, à avaliação psicológica, por meio das Escalas Wechsler de Inteligência e à avaliação fonoaudiológica específica de linguagem. Para avaliação do vocabulário, fonologia, sintaxe, pragmática, leitura e escrita foram utilizados testes como: as Figuras temáticas do Yavas, o ABFW - Teste de Linguagem Infantil, o Peabody Picture Vocabulary Test (PPVT), além de outros protocolos específicos. RESULTADOS: os exames de ressonância magnética evidenciaram polimicrogiria perisylviana de localização e extensão variáveis em todos os sujeitos. A avaliação fonoaudiológica também demonstrou alterações de linguagem oral e escrita significativas em todos os sujeitos. CONCLUSÃO: os nossos dados mostraram que distúrbios de linguagem podem co-ocorrer com alterações de leitura em membros da mesma família. A constatação de alterações corticais evidencia a presença de distúrbios específicos da linguagem no espectro da síndrome perisylviana. Outro aspecto importante evidenciado nesse estudo é a semelhança do perfil de linguagem entre os irmãos e a mãe, sugerindo que seja possível a existência de uma variedade de manifestações lingüísticas dentro do espectro da referida síndrome, podendo ser a polimicrogiria perisylviana um dos substratos neurobiológicos destes distúrbios.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Unicamp Faculdade de Ciências MédicasUnicamp Departamento de NeurologiaUniversidade Federal de São Paulo (UNIFESP)Unicamp FCM Departamento de Genética MédicaUniversidade de São Paulo Faculdade de Odontologia Departamento de FonoaudiologiaUNIFESPSciEL