Deepwater Ports

This paper is designed to provide an overview of the oil energy import problem and an analysis in a case study format of the various deepwater port alternatives for direct shipment and transshipment of foreign crude oil. This work was initiated prior to the recent expanded energy crisis and although touches on the problems of dependency of the United States to foreign crude oil, the various alternative sources of energy, the essence of this paper is an analysis of the various deepwater port considerations for the direct or indirect importation of foreign crude oil; specifically along the Gulf Coast

Stick-Slip Squeal in a Dry Scroll Vacuum Pump

ABSTRACT  Vacuum pumps have been described as compressors for rarefied gases. For more than twenty-five years the scroll compressor principle has been used in designing vacuum pumps that do not rely on oil to provide their pumping action. The dry scroll vacuum pump has been particularly successful as a source of rough vacuum for analytical instruments such as liquid-chromatography or gas-chromatography mass spectrometers. Such instruments are typically located in quiet laboratory environments where the scroll vacuum pump may be the only significant source of noise. Consequently, quiet operation is a key requirement of dry scroll vacuum pumps.  This paper discusses an occurrence of stick-slip squeal that developed during the design of a new model, low noise, dry scroll pump. Stick-slip phenomena and the associated noise are the result of self-excited oscillations related to the difference between static and sliding friction. Rapidly oscillating friction forces occurring during a portion of the orbital cycle can result in induced vibration of the participating surfaces and structure, which radiate high-pitched noise.  In the case described, considerable effort was expended in developing a design that would be quiet in comparison with other models in the marketplace. The occurrence of a loud chirping noise, determined to be due to a stick-slip behavior, in a late stage prototype, caused a good deal of concern and a flurry of activity to fully characterize the vibration behavior within the pump related to the noise and to develop design modifications to ensure that the noise was eliminated. The characteristics of the noise are described for the scroll pump along with the methods utilized to eliminate it from the design

Independent Component Analysis for Brain fMRI Does Indeed Select for Maximal Independence

A recent paper by Daubechies et al. claims that two independent component analysis (ICA) algorithms, Infomax and FastICA, which are widely used for functional magnetic resonance imaging (fMRI) analysis, select for sparsity rather than independence. The argument was supported by a series of experiments on synthetic data. We show that these experiments fall short of proving this claim and that the ICA algorithms are indeed doing what they are designed to do: identify maximally independent sources

A Raman lidar to measure water vapor in the atmospheric boundary layer

A new multi-telescope scanning Raman lidar designed to measure the water vapor mixing ratio in the atmospheric boundary layer for a complete diurnal cycle with high resolution spatial (1.25 m) and temporal (1 s) resolutions is presented. The high resolution allows detailed measurements of the lower atmosphere and offers new opportunities for evaporation and boundary layer research, atmospheric profiling and visualization. This lidar utilizes a multi-telescope design that provides for an operational range with a nearly constant signal-to-noise ratio, which allows for statistical investigations of atmospheric turbulence. This new generation ground-based water vapor Raman lidar is described, and first observations from the Turbulent Atmospheric Boundary Layer Experiment (TABLE) are presented. Direct comparison with in-situ point measurements obtained during the field campaign demonstrate the ability of the lidar to reliably measure the water vapor mixing ratio. Horizontal measurements taken with time are used to determine the geometric characteristics of coherent structures. Vertical scans are used to visualize nocturnal jet features, layered structures within a stably stratified atmosphere and the internal boundary layer structure over a lake. (C) 2012 Elsevier Ltd. All rights reserved

A Raman lidar to measure water vapor in the atmospheric boundary layer

A new multi-telescope scanning Raman lidar designed to measure the water vapor mixing ratio for a complete diurnal cycle with high raw spatial (1.25 m) and temporal (1 s) resolutions is presented. The high resolution allows detailed measurements of the lower atmosphere and offers new opportunities for boundary layer research, atmospheric profiling and visualization. This lidar utilizes a multi-telescope design that provides for an operational range with a nearly constant signal-to-noise ratio, which allows for statistical investigations of atmospheric turbulence. This new generation ground-based water vapor Raman lidar is described, and first observations from the Turbulent Atmospheric Boundary Layer Experiment (TABLE) are presented. Direct comparison with in-situ point measurements obtained during the field campaign demonstrate the ability of the lidar to reliably measure the water vapor mixing ratio. Horizontal measurements taken with time are used to determine the geometric characteristics of coherent structures. Vertical scans are used to visualize nocturnal jet features, layered structures within a stably stratified atmosphere and the internal boundary layer structure over a lake.Keywords: Atmospheric Boundary Layer, Water Vapor, Raman Lida

Fully Autonomous Mixed Signal SoC Design & Layout Generation Platform

We present FASoC, the world’s first autonomous mixed-signal SoC framework driven entirely by user constraints, along with a suite of automated generators for analog blocks. The process agnostic framework takes high-level user intent as inputs to generate optimized and fully verified analog blocks using a cell-based design methodology. Our approach is highly scalable and silicon-proven by an SoC prototype which includes 2 PLLs, 3 LDOs, 1 SRAM, and 2 temperature sensors fully integrated with a processor in a 65nm CMOS process. The physical design of all blocks, including analog, is achieved using optimized synthesis and APR flows in commercially available tools. The framework is portable across different processes and requires no human in the loop, dramatically accelerating design time.This material is based on research sponsored by Air Force Research Laboratory (AFRL) and Defense Advanced Research Projects Agency (DARPA) under agreement number FA8650 18 2 7844. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/165331/1/Fully Autonomous Mixed Signal SoC Design & Layout Generation Platform.pdfDescription of Fully Autonomous Mixed Signal SoC Design & Layout Generation Platform.pdf : Main articleSEL

Non-Stationarity in the “Resting Brain’s” Modular Architecture

Task-free functional magnetic resonance imaging (TF-fMRI) has great potential for advancing the understanding and treatment of neurologic illness. However, as with all measures of neural activity, variability is a hallmark of intrinsic connectivity networks (ICNs) identified by TF-fMRI. This variability has hampered efforts to define a robust metric of connectivity suitable as a biomarker for neurologic illness. We hypothesized that some of this variability rather than representing noise in the measurement process, is related to a fundamental feature of connectivity within ICNs, which is their non-stationary nature. To test this hypothesis, we used a large (n = 892) population-based sample of older subjects to construct a well characterized atlas of 68 functional regions, which were categorized based on independent component analysis network of origin, anatomical locations, and a functional meta-analysis. These regions were then used to construct dynamic graphical representations of brain connectivity within a sliding time window for each subject. This allowed us to demonstrate the non-stationary nature of the brain’s modular organization and assign each region to a “meta-modular” group. Using this grouping, we then compared dwell time in strong sub-network configurations of the default mode network (DMN) between 28 subjects with Alzheimer’s dementia and 56 cognitively normal elderly subjects matched 1∶2 on age, gender, and education. We found that differences in connectivity we and others have previously observed in Alzheimer’s disease can be explained by differences in dwell time in DMN sub-network configurations, rather than steady state connectivity magnitude. DMN dwell time in specific modular configurations may also underlie the TF-fMRI findings that have been described in mild cognitive impairment and cognitively normal subjects who are at risk for Alzheimer’s dementia

Rare Copy Number Deletions Predict Individual Variation in Intelligence

Phenotypic variation in human intellectual functioning shows substantial heritability, as demonstrated by a long history of behavior genetic studies. Many recent molecular genetic studies have attempted to uncover specific genetic variations responsible for this heritability, but identified effects capture little variance and have proven difficult to replicate. The present study, motivated an interest in “mutation load” emerging from evolutionary perspectives, examined the importance of the number of rare (or infrequent) copy number variations (CNVs), and the total number of base pairs included in such deletions, for psychometric intelligence. Genetic data was collected using the Illumina 1MDuoBeadChip Array from a sample of 202 adult individuals with alcohol dependence, and a subset of these (N = 77) had been administered the Wechsler Abbreviated Scale of Intelligence (WASI). After removing CNV outliers, the impact of rare genetic deletions on psychometric intelligence was investigated in 74 individuals. The total length of the rare deletions significantly and negatively predicted intelligence (r = −.30, p = .01). As prior studies have indicated greater heritability in individuals with relatively higher parental socioeconomic status (SES), we also examined the impact of ethnicity (Anglo/White vs. Other), as a proxy measure of SES; these groups did not differ on any genetic variable. This categorical variable significantly moderated the effect of length of deletions on intelligence, with larger effects being noted in the Anglo/White group. Overall, these results suggest that rare deletions (between 5% and 1% population frequency or less) adversely affect intellectual functioning, and that pleotropic effects might partly account for the association of intelligence with health and mental health status. Significant limitations of this research, including issues of generalizability and CNV measurement, are discussed

Frequency drift in MR spectroscopy at 3T

Purpose: Heating of gradient coils and passive shim components is a common cause of instability in the B-0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time field-frequency locking on MRI scanners by comparing field drift data from a large number of sites.Method: A standardized protocol was developed for 80 participating sites using 99 3T MR scanners from 3 major vendors. Phantom water signals were acquired before and after an EPI sequence. The protocol consisted of: minimal preparatory imaging; a short pre-fMRI PRESS; a ten-minute fMRI acquisition; and a long post-fMRI PRESS acquisition. Both pre- and post-fMRI PRESS were non-water suppressed. Real-time frequency stabilization/adjustment was switched off when appropriate. Sixty scanners repeated the protocol for a second dataset. In addition, a three-hour post-fMRI MRS acquisition was performed at one site to observe change of gradient temperature and drift rate. Spectral analysis was performed using MATLAB. Frequency drift in pre-fMRI PRESS data were compared with the first 5:20 minutes and the full 30:00 minutes of data after fMRI. Median (interquartile range) drifts were measured and showed in violin plot. Paired t-tests were performed to compare frequency drift pre- and post-fMRI. A simulated in vivo spectrum was generated using FID-A to visualize the effect of the observed frequency drifts. The simulated spectrum was convolved with the frequency trace for the most extreme cases. Impacts of frequency drifts on NAA and GABA were also simulated as a function of linear drift. Data from the repeated protocol were compared with the corresponding first dataset using Pearson's and intraclass correlation coefficients (ICC).Results: Of the data collected from 99 scanners, 4 were excluded due to various reasons. Thus, data from 95 scanners were ultimately analyzed. For the first 5:20 min (64 transients), median (interquartile range) drift was 0.44 (1.29) Hz before fMRI and 0.83 (1.29) Hz after. This increased to 3.15 (4.02) Hz for the full 30 min (360 transients) run. Average drift rates were 0.29 Hz/min before fMRI and 0.43 Hz/min after. Paired t-tests indicated that drift increased after fMRI, as expected (p &lt; 0.05). Simulated spectra convolved with the frequency drift showed that the intensity of the NAA singlet was reduced by up to 26%, 44 % and 18% for GE, Philips and Siemens scanners after fMRI, respectively. ICCs indicated good agreement between datasets acquired on separate days. The single site long acquisition showed drift rate was reduced to 0.03 Hz/min approximately three hours after fMRI.Discussion: This study analyzed frequency drift data from 95 3T MRI scanners. Median levels of drift were relatively low (5-min average under 1 Hz), but the most extreme cases suffered from higher levels of drift. The extent of drift varied across scanners which both linear and nonlinear drifts were observed.</p